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Effectiveness and safety of oral anticoagulants for non-valvular atrial fibrillation: a population-based cohort study in primary healthcare in Catalonia
Conclusion: Being men, a previous event and DOAC-switch posed a higher risk for all study outcomes. direct oral anticoagulants had a protective effect against cerebral bleeding in comparison to vitamin K antagonists. Adherence to direct oral anticoagulants resulted in lower risk of stroke and cerebral bleeding. We found no differences in the risk of stroke and gastrointestinal bleeding when we compared direct oral anticoagulants vs. vitamin K antagonists.
Source: Frontiers in Pharmacology - September 15, 2023 Category: Drugs & Pharmacology Source Type: research

Real-World Racial Variation in Treatment and Outcomes Among Patients with Peripheral Artery Disease
ConclusionsResults of this real-world study suggest that Black patients with PAD have higher disease severity at the time of diagnosis and are at increased risk of experiencing adverse outcomes following diagnosis.
Source: Advances in Therapy - March 6, 2023 Category: Drugs & Pharmacology Source Type: research

Identification of Secondary Prevention Patients Eligible for PCSK9 Inhibitors Therapy According to the Routine Clinical Practice in Spain
ConclusionUp to 82% of patients with atherosclerotic CV disease do not achieve LDL-C levels recommended by the 2019 ESC/EAS guidelines despite being on optimized oral LLT therapy. In 17.9% of these patients LDL-C levels exceed 100  mg/dL, being eligible for PCSK9i in Spain.
Source: Advances in Therapy - December 16, 2022 Category: Drugs & Pharmacology Source Type: research

A literature review of hypertensive retinopathy: systemic correlations and new technologies
CONCLUSIONS: The eye is the only organ in the human body where changes in the blood vessels due to systemic hypertension can be studied in vivo. All doctors should be familiar with this disease because it has been largely demonstrated that signs of HR are correlated to patient's health and mortality. Researchers should develop a new common, standardized, and objective method to assess hypertensive retinal changes; new technologies may have a significant role in this field. This review takes most of the literature published so far, including the OCTA studies in order to stimulate new points of reference to standardize param...
Source: Pharmacological Reviews - October 5, 2022 Category: Drugs & Pharmacology Authors: E Di Marco F Aiello M Lombardo M Di Marino F Missiroli R Mancino F Ricci C Nucci A Noce N Di Daniele M Cesareo Source Type: research

The immunomodulatory effects of antihypertensive therapy: A review
Biomed Pharmacother. 2022 Jun 18;153:113287. doi: 10.1016/j.biopha.2022.113287. Online ahead of print.ABSTRACTHypertension remains the leading preventable risk factor for stroke and coronary artery disease, significantly contributing to all-cause global mortality and predisposing patients to renal and heart failure, as well as peripheral vascular disease. Due to the widespread usage of antihypertensive drugs, global mean blood pressure has remained unchanged or even slightly decreased over the past four decades. However, considering the broad spectrum of mechanisms involved in the action of antihypertensive drugs and the p...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 21, 2022 Category: Drugs & Pharmacology Authors: Dominik Felkle Mateusz Jarczy ński Konrad Kaleta Katarzyna Zi ęba Katarzyna Nazimek Source Type: research

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