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Condition: Obesity
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Total 95554 results found since Jan 2013.
NIH to fund Centers of Excellence on Minority Health and Health Disparities
The National Institute on Minority Health and Health Disparities will fund 12 specialized research centers to conduct research, research training, and community engagement activities focused on improving minority health and reducing health disparities. The grantees are:
Leveraging Bio-Cultural Mechanisms to Maximize the Impact of Multi-Level Preventable Disease Interventions with Southwest Populations; Flavio Marsiglia, Ph.D., Arizona State University, Tempe
Involving Communities in Delivering and Disseminating Health Disparity Interventions; Ashwini Sehgal, M.D., Case Western Reserve University, Cleveland
Duke Center ...
Source: BHIC - October 18, 2017 Category: Databases & Libraries Authors: Annette Parde-Maass Tags: Minority Health Concerns NIH Source Type: blogs
Obesity, risk of biochemical recurrence, and prostate ‐specific antigen doubling time after radical prostatectomy: results from the SEARCH database
ConclusionWhile we confirmed that higher BMI was associated with BCR, we found no link between BMI and PSADT at the time of recurrence. Our data suggest obese men do not have more aggressive recurrences. Future studies are needed to test whether obesity predicts response to salvage therapies.
Source: BJU International - November 16, 2018 Category: Urology & Nephrology Authors: Stephen J. Freedland,
Brandee L. Branche,
Lauren E. Howard,
Robert J. Hamilton,
William J. Aronson,
Martha K. Terris,
Matthew R. Cooperberg,
Christopher L. Amling,
Christopher J. Kane,
On behalf of the SEARCH Database Study Group Tags: Original Article Source Type: research
Cannabinoid Receptor 1 (CB1) Inverse Agonists for the Treatment of Diabetes, Obesity and their Complications
Endocannabinoids are lipid signaling molecules that act on the same cannabinoid receptors – CB1 and CB2 – that recognize and mediate the effects of marijuana. Activation of CB1 receptors increases appetite and the biosynthesis and storage of lipids, inhibits the actions of insulin and leptin, and promotes tissue inflammation and fibrosis. This has led to the development of CB1 receptor blocking drugs (inverse agonists) for the treatment of obesity and its metabolic complications, referred to as the metabolic syndrome. However, many CB1 inverse agonists can cross the blood-brain barrier, causing psychiatric side effect...
Source: NIH OTT Licensing Opportunities - October 18, 2013 Category: Research Authors: admin Source Type: research
Remotely Monitored Mouse Feeding Experimentation Device
How much does a mouse eat per day? If a researcher is conducting dietary studies, the answer is very important. For instance, obesity studies require accurate measures of feeding. Existing automated methods for taking feeding measurements are expensive and use specialized caging that is not compatible with typical vivarium colony racks. As a result, many researchers simply weigh food each day or two to determine how much food the mice ate. This is time-consuming, can be error prone, and provides a low temporal resolution view of feeding. To address this need, a compact, 3D printed, electronic, feeding experimentation devi...
Source: NIH OTT Licensing Opportunities - July 26, 2016 Category: Research Authors: ajoyprabhu3 Source Type: research
Substituted Quinoline Analogs as Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors
Aldehyde dehydrogenase enzymes (ALDHs) have a broad spectrum of biological activities through the oxidation of both endogenous and exogenous aldehydes. Unbalanced biological activity of ALDHs has been associated with a variety of disease states such as alcoholic liver disease, Parkinson ’s disease, obesity, and Cancer. Increased expression of ALDH1A1 has been identified in a wide-range of human cancer stem cells and is associated with cancer relapse and poor prognosis, raising the potential of ALDH1A1 as a therapeutic target.We performed a systematic medicinal chemistry optimization and biological characterization of new...
Source: NIH OTT Licensing Opportunities - February 6, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research
NIH study finds cutting dietary fat reduces body fat more than cutting carbs
19 adults with obesity participated in the study at the NIH Clinical Center.
Source: National Institutes of Health (NIH) News Releases - August 13, 2015 Category: American Health Source Type: news
Small interfering RNA Knock-down of Cannabinoid-1 Receptor (CB1R) for the Treatment or Prevention of Type-2 Diabetes
Endocannabinoids (EC) are lipid signaling molecules that act on the same cannabinoid receptors that recognize and mediate the effects of marijuana. Activation of the EC receptor CB1R has been shown to play a key role in the development of obesity and its metabolic consequences, including insulin resistance and type 2 diabetes. Researchers at NIH have now demonstrated in the Zucker diabetic fatty (ZDF) rat model of type-2 diabetes that beta-cell loss is caused by the CB1R-mediated activation of a macrophage-mediated inflammatory response. They have further demonstrated that treatment of ZDF rats with a peripheral CB1R antag...
Source: NIH OTT Licensing Opportunities - September 19, 2013 Category: Research Authors: admin Source Type: research
Large NIH study to collect and share data on the impact on kids ’ brains of screen time and other social, behavioral, physical and environmental factors
NIH Study Probes Impact of Heavy Screen Time on Young Brains (Bloomberg):
“Brain scans of adolescents who are heavy users of smartphones, tablets and video games look different from those of less active screen users, preliminary results from an ongoing study funded by the National Institutes of Health show … That’s the finding of the first batch of scans of 4,500 nine- to 10-year-olds. Scientists will follow those children and thousands more for a decade to see how childhood experiences, including the use of digital devices, affect their brains, emotional development and mental health…
Early re...
Source: SharpBrains - December 17, 2018 Category: Neuroscience Authors: SharpBrains Tags: Cognitive Neuroscience Education & Lifelong Learning Health & Wellness Technology Adolescent Brain Cognitive Development adolescents brain-scans digital devices Mental-Health neuroimaging NIH screen time smartphones Source Type: blogs
Strategies for enhancing the implementation of school-based policies or practices targeting diet, physical activity, obesity, tobacco or alcohol use
CONCLUSIONS: The use of implementation strategies may result in large increases in implementation of interventions, and slight improvements in measures of student diet, and physical activity. Further research is required to assess the impact of implementation strategies on such behavioural- and obesity-related outcomes, including on measures of alcohol use, where the findings of one trial suggest it may slightly increase student risk. Given the low certainty of the available evidence for most measures further research is required to guide efforts to facilitate the translation of evidence into practice in this setting.PMID:...
Source: Cochrane Database of Systematic Reviews - August 29, 2022 Category: General Medicine Authors: Luke Wolfenden Sam McCrabb Courtney Barnes Kate M O'Brien Kwok W Ng Nicole K Nathan Rachel Sutherland Rebecca K Hodder Flora Tzelepis Erin Nolan Christopher M Williams Sze Lin Yoong Source Type: research
A Study of Safety, Tolerability, and Pharmacokinetics of Multiple-Ascending Doses of PHP-303 in Otherwise Healthy Overweight or Obese Subjects
Condition: Otherwise Healthy Overweight or Obese Interventions: Drug: PHP-303; Other: Placebo Sponsor: pH Pharma Not yet recruiting
Source: ClinicalTrials.gov - December 13, 2018 Category: Research Source Type: clinical trials
