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Condition: Menopause
Drug: Medroxyprogesterone
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Total 92 results found since Jan 2013.
Evaluations of memory, anxiety, and the growth factor IGF-1R after post-surgical menopause treatment with a highly selective progestin
Behav Brain Res. 2023 Apr 19:114442. doi: 10.1016/j.bbr.2023.114442. Online ahead of print.ABSTRACTProgestogens are a key component of menopausal hormone therapies. While some progestogens can be detrimental to cognition, there is preclinical evidence that progestogens with a strong progesterone-receptor affinity benefit some molecular mechanisms believed to underlie cognitive function. Thus, a progestin that maximizes progesterone-receptor affinity and minimizes affinities to other receptors may be cognitively beneficial. We evaluated segesterone-acetate (SGA), a 19-norprogesterone derivative with a strong progesterone-re...
Source: Behavioural Brain Research - April 19, 2023 Category: Neurology Authors: Victoria E Bernaud Stephanie V Koebele Steven N Northup-Smith Mari N Willeman Charlotte Barker Alex Schatzki-Lumpkin Maria Valenzuela Sanchez Heather A Bimonte-Nelson Source Type: research
Retrospective study on the effectiveness of medroxyprogesterone acetate in the treatment of ER-positive/HER2-negative post-menopausal advanced breast cancer: an additional analysis of the JBCRG-C06 Safari study
Jpn J Clin Oncol. 2022 Dec 8:hyac184. doi: 10.1093/jjco/hyac184. Online ahead of print.NO ABSTRACTPMID:36484305 | DOI:10.1093/jjco/hyac184
Source: Clinical Breast Cancer - December 9, 2022 Category: Cancer & Oncology Authors: Hidetoshi Kawaguchi Yutaka Yamamoto Shigehira Saji Norikazu Masuda Takahiro Nakayama Kenjiro Aogi Keisei Anan Shoichiro Ohtani Nobuaki Sato Toshimi Takano Eriko Tokunaga Seigo Nakamura Yoshie Hasegawa Masaya Hattori Tomomi Fujisawa Satoshi Morita Miki Yam Source Type: research
Lifestyle and personal factors associated with having macroscopic residual disease after ovarian cancer primary cytoreductive surgery
CONCLUSIONS: The association between ET and having no macroscopic residual disease is plausible given a strong underlying biologic hypothesis between this exposure and diagnosis with HGSC. If this or the parity finding is replicated, these factors could be included in risk stratification models to determine whether HGSC patients should receive PCS or neoadjuvant chemotherapy.PMID:36401943 | DOI:10.1016/j.ygyno.2022.10.018
Source: Ann Oncol - November 19, 2022 Category: Cancer & Oncology Authors: Minh Tung Phung Penelope M Webb Anna DeFazio Sian Fereday Alice W Lee David D L Bowtell Peter A Fasching Ellen L Goode Marc T Goodman Beth Y Karlan Jenny Lester Keitaro Matsuo Francesmary Modugno James D Brenton Toon Van Gorp Paul D P Pharoah Joellen M Sc Source Type: research
Hormonal drugs for the treatment of endometriosis
Curr Opin Pharmacol. 2022 Oct 20;67:102311. doi: 10.1016/j.coph.2022.102311. Online ahead of print.ABSTRACTIn the past, the primary approach for the treatment of endometriosis was represented by surgery; however, after the introduction of non-invasive diagnosis of endometriosis with the development of imaging technologies, medical treatment became the preferred approach, particularly in young patients. Hormonal drugs, by blocking menstruation, are the most effective for the treatment of endometriosis-related pain, independently of phenotype (ovarian, deep, or superficial endometriosis). Gonadotropin-releasing hormone analo...
Source: Current Opinion in Pharmacology - October 24, 2022 Category: Drugs & Pharmacology Authors: Tommaso Capezzuoli Margherita Rossi Francesco La Torre Silvia Vannuccini Felice Petraglia Source Type: research
Pulmonary embolism in menopausal hormone therapy: a population-based register study
CONCLUSION: PE was most common close to initiation of oral treatment. Transdermal MHT did not increase the risk of PE.PMID:36218141 | DOI:10.1080/13697137.2022.2127352
Source: Climacteric - October 11, 2022 Category: Geriatrics Authors: Micaela Sundell Anna-Clara Spetz Holm Mats Fredrikson Mats Hammar Mikael Hoffmann Jan Brynhildsen Source Type: research
