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Alcohol Consumption and Cerebral Small- and Large-Vessel Diseases: A Mendelian Randomization Analysis
CONCLUSIONS: Our findings suggest a positive association of alcohol consumption with risk of cerebral SVDs and its inverse association with risk of large-vessel disease through intermediaries, such as hypertension or low-density lipoprotein cholesterol. These findings provide insight into potential causal mechanisms linking alcohol consumption with stroke risk.PMID:37612092 | DOI:10.5551/jat.64222
Source: Journal of Atherosclerosis and Thrombosis - August 23, 2023 Category: Cardiology Authors: Takashi Hisamatsu Yasuharu Tabara Aya Kadota Sayuki Torii Keiko Kondo Yuichiro Yano Akihiko Shiino Kazuhiko Nozaki Tomonori Okamura Hirotsugu Ueshima Katsuyuki Miura SESSA Research Group Source Type: research

The effect of intensive statin therapy in non-symptomatic intracranial arteries: The STAMINA-MRI sub-study
CONCLUSION: Intensive statin therapy produced a favorable morphological change in cerebral arteries of not only the target arterial segment but also non-symptomatic arterial segments. The change in cerebral arterial luminal diameter was influenced by the baseline SBP and was dependent on the topographic distribution of the cerebral arteries.Clinical Trial Registration: ClinicalTrials.gov, identifier NCT02458755.PMID:37056360 | PMC:PMC10088516 | DOI:10.3389/fneur.2023.1069502
Source: Atherosclerosis - April 14, 2023 Category: Cardiology Authors: Jae Eun Sim Ha-Na Song Jong-Un Choi Ji-Eun Lee In Young Baek Hwan-Ho Cho Jong-Hoon Kim Jong-Won Chung Gyeong-Moon Kim Hyun-Jin Park Oh Young Bang Woo-Keun Seo Source Type: research

Mitral Valve Blood Cyst and Multi-Territory Ischaemic Stroke
A 78-year-old male with a history of hypertension and hypercholesterolaemia was admitted to hospital with acute left eye visual loss and diagnosed with retinal artery occlusion. Magnetic resonance imaging (MRI) revealed multiple, bilateral cerebral infarcts involving supra- and infra-tentorial brain consistent with acute ischaemic stroke from a central embolic source. Extended ambulatory electrocardiographic monitoring displayed sinus rhythm with no evidence of atrial flutter or fibrillation. Transthoracic echocardiography (TTE) revealed a cystic structure associated with the mitral valve, with no restriction or regurgitation.
Source: Heart, Lung and Circulation - February 16, 2023 Category: Cardiology Authors: Caitlin Paul, Luke Cieslik, Alan Appelbe, Catherine Jaworski Tags: Image Source Type: research

A Non-Linear Role of Hyperlipidemia on Progression of Intracranial Atherosclerotic Plaques and Acute Downstream Ischemic Events
CONCLUSIONS: LDL was related with ischemia events in intermediate stage of intracranial atherosclerotic plaque progression, an excellent period for intensive lipid-lowering treatment. In advanced stage, inflammatory agents maybe the main contributor to ischemic events.PMID:36709996 | DOI:10.5551/jat.63971
Source: Journal of Atherosclerosis and Thrombosis - January 29, 2023 Category: Cardiology Authors: Jianxia Ke Jinrui Li Junting Chen Chengze Lai Weicheng Zheng Xiaoli Fu Xuewen Fang Lianxian Guo Zhu Shi Source Type: research

Carotid contrast-enhanced ultrasonography combined with sirtuin-3 in the diagnosis of plaques in carotid atherosclerosis
CONCLUSIONS: A low expression of SIRT3 predicted a higher risk for unstable plaques in CAS patients. The combination of CEUS and SIRT3 is a potential strategy for diagnosing unstable plaques.PMID:36083252 | DOI:10.17219/acem/152471
Source: Atherosclerosis - September 9, 2022 Category: Cardiology Authors: Aiyun Zhou Wan Zhu Pan Xu Chunxiao Zhao Liping Jiang Wenxin Yuan Source Type: research

Imaging High-Risk Atherothrombosis Using a Novel Fibrin-Binding Positron Emission Tomography Probe
CONCLUSIONS: We demonstrated that molecular fibrin PET imaging using 68Ga-CM246 could be a useful tool to diagnose experimental and clinical atherothrombosis. Based on our initial results using human carotid plaque specimens, in vivo molecular imaging studies are warranted to test 68Ga-CM246 PET as a tool to stratify risk in atherosclerotic patients.PMID:34965737 | DOI:10.1161/STROKEAHA.121.035638
Source: Atherosclerosis - December 30, 2021 Category: Cardiology Authors: David Izquierdo-Garcia Himashinie Diyabalanage Ian A Ramsay Nicholas J Rotile Adam Mauskapf Ji-Kyung Choi Thomas Witzel Valerie Humblet Farouc A Jaffer Anna-Liisa Brownell Ahmed Tawakol Ciprian Catana Mark F Conrad Peter Caravan Ilknur Ay Source Type: research

Effect of high-dose strong statin for preventing periprocedural ischemic complications of carotid artery stenting
This study assessed the safety and usefulness of pretreatment using a high-dose strong statin (HDSS) to reduce the periprocedural ischemic complications of CAS. We analyzed 117 carotid lesions treated by CAS that were evaluated with magnetic resonance imaging (MRI) within 48  h after the procedure. For 67 lesions, an HDSS (rosuvastatin 20 mg or atorvastatin 40 mg daily) were prescribed from at least 14 days before CAS to at least 14 days after procedure (HDSS group). Clinical and angiographic data, as well as in-hospital outcomes, of the HDSS group were retrospecti vely compared with 50 lesions with conventional treat...
Source: Heart and Vessels - January 9, 2020 Category: Cardiology Source Type: research

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