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Condition: Cholesterol
Procedure: Ultrasound
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Total 140 results found since Jan 2013.
An Ultrasound-Responsive Theranostic Cyclodextrin-Loaded Nanoparticle for Multimodal Imaging and Therapy for Atherosclerosis
This study reports CD delivery via air-trapped polybutylcyanoacrylate nanoparticles (with diameters of 388 ± 34 nm) loaded with CD (CDNPs). The multimodal contrast ability of these nanoparticles after being loaded with IR780 dye in mice is demonstrated using ultrasound and near-infrared imaging. It is shown that CDNPs enhance the cellular uptake of CD in murine cells. In an ApoE-/- mouse model of atherosclerosis, treatment with CDNPs significantly improves the anti-atherosclerotic efficacy of CD. Ultrasound triggering further improves CD uptake, highlighting that CDNPs can be used for ultrasound imaging and ultrasound-res...
Source: Atherosclerosis - June 17, 2022 Category: Cardiology Authors: Sourabh Mehta Viktoria Bongcaron Tien K Nguyen Yugandhara Jirwanka Ana Maluenda Aidan P G Walsh Jathushan Palasubramaniam Mark D Hulett Rohit Srivastava Alex Bobik Xiaowei Wang Karlheinz Peter Source Type: research
An Ultrasound ‐Responsive Theranostic Cyclodextrin‐Loaded Nanoparticle for Multimodal Imaging and Therapy for Atherosclerosis
This study reports CD delivery via air-trapped polybutylcyanoacrylate nanoparticles (with diameters of 388 ± 34 nm) loaded with CD (CDNPs). The multimodal contrast ability of these nanoparticles after being loaded with IR780 dye in mice is demonstrated using ultrasound and near-infrared imaging. It is shown that CDNPs enhance the cellular uptake of CD in murine cells. In an ApoE–/– mouse model of atherosclerosis, treatment with CDNPs significantly improves the anti-atherosclerotic efficacy of CD. Ultrasound triggering further improves CD uptake, highlighting that CDNPs can be used for ultrasound imaging and ultras...
Source: Small - June 17, 2022 Category: Nanotechnology Authors: Sourabh Mehta,
Viktoria Bongcaron,
Tien K Nguyen,
Yugandhara Jirwanka,
Ana Maluenda,
Aidan P G Walsh,
Jathushan Palasubramaniam,
Mark D Hulett,
Rohit Srivastava,
Alex Bobik,
Xiaowei Wang,
Karlheinz Peter Tags: Research Article Source Type: research
Modern Treatment of Asymptomatic Carotid Stenosis —The Importance of Both Medical Therapy and Carotid Endarterectomy
Each year there are approximately 700 000 new ischemic strokes in the US, and 10% to 15% of them are caused by thromboembolism from a previously asymptomatic carotid stenosis (ACS). Three large randomized clinical trials, published in the 1990s and early 2000s, have demonstrated a significant benefit of carotid endarterectomy (CEA) i n preventing stroke in patients with severe ACS compared with medical therapy alone. They showed a 50% relative risk reduction in 5-year stroke rate and an approximately 1% per year absolute stroke risk reduction. Over the course of the past 2 decades, there has been significant improvement...
Source: JAMA Surgery - June 8, 2022 Category: Sports Medicine Source Type: research
Correlation Between Carotid Intima Media Thickness and Non-Alcoholic Fatty Liver Disease
CONCLUSION: CIMT is increased in NAFLD patients. Increase in CIMT is significantly correlated with increasing grades of NAFLD. Hence CIMT can be used as screening tests in NALFD patients to assess cardiovascular risks.PMID:35443534
Source: Journal of the Association of Physicians of India - April 21, 2022 Category: General Medicine Authors: Shalini Kumari Y C Porwal Rohini Gupta Source Type: research
