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Dyslipidemia Increases the Risk of Incident Hypertension in a Large Taiwanese Population Follow-Up Study
In this study, we investigated correlations between lipid profiles, including triglycerides, total cholesterol (Chol), high-and low-density lipoprotein cholesterol (HDL-C/LDL-C), and Chol/HDL-C, and baseline and incident hypertension. A total of 26,965 subjects with 4 years of follow-up data were enrolled from the Taiwan Biobank. In the cross-sectional cohort, associations between the prevalence of hypertension and lipid profiles were examined in all study participants (n = 26,965). In the longitudinal cohort, these associations were further assessed in the participants without baseline hypertension (n = 21,454). Multivari...
Source: Atherosclerosis - August 26, 2022 Category: Cardiology Authors: Yu-Hsuan Lin Yi-Hsueh Liu Da-Wei Wu Ho-Ming Su Szu-Chia Chen Source Type: research

PCSK9 inhibition in patients with acute stroke and symptomatic intracranial atherosclerosis: protocol for a prospective, randomised, open-label, blinded end-point trial with vessel-wall MR imaging
BMJ Open. 2022 Apr 29;12(4):e060068. doi: 10.1136/bmjopen-2021-060068.ABSTRACTINTRODUCTION: Dual antiplatelet therapy and high-intensity statins are the mainstay treatment in patients with acute stage, symptomatic intracranial atherosclerotic stenosis (ICAS). Alirocumab is a monoclonal antibody that can inhibit proprotein convertase subtilisin-kexin type 9 and effectively lower low-density lipoprotein cholesterol levels with less side effects than statins. We hypothesise that alirocumab treatment in addition to statin therapy could stabilise intracranial plaque and reduce arterial stenosis.METHODS AND ANALYSIS: In this pro...
Source: Atherosclerosis - April 29, 2022 Category: Cardiology Authors: Yen-Chu Huang Chia-Hao Chang Yuan-Hsiung Tsai Hsu-Huei Weng Leng-Chieh Lin Jiann-Der Lee Source Type: research

2022 focused update of the 2017 Taiwan lipid guidelines for high risk patients: Coronary artery disease, peripheral artery disease and ischemic stroke
J Formos Med Assoc. 2022 Apr 8:S0929-6646(22)00103-6. doi: 10.1016/j.jfma.2022.03.001. Online ahead of print.ABSTRACTThe previously published 2017 Taiwan Lipid Guidelines for High Risk Patients becomes the standard guidance of dyslipidemia management for patients with atherosclerotic cardiovascular disease (ASCVD) in Taiwan. New clinical trials of lipid lowering therapy were published successively after 2017. The study results changed the treatment concept of ASCVD. Therefore, an update focusing on the lipid treatment strategy for patients with ASCVD becomes necessary. In this focused update of the 2017 guideline, the trea...
Source: Atherosclerosis - April 12, 2022 Category: Cardiology Authors: Po-Sheng Chen Meng Lee Sung-Chun Tang Po-Hsun Huang Hung-I Yeh Charles Jia-Yin Hou I-Chang Hsieh Jiunn-Tay Lee Jiann-Shing Jeng Yi-Heng Li Source Type: research

Prognostic indicators for the onset of ischaemic versus haemorrhagic stroke in stable coronary artery disease
Medicine (Baltimore). 2021 Dec 3;100(48):e27973. doi: 10.1097/MD.0000000000027973.ABSTRACTThe incidence of stroke may be increased in patients with coronary artery disease (CAD). We aimed to investigate the specific risk factors for the development of ischaemic and haemorrhagic stroke in stable CAD patients.Patients with stable CAD were prospectively enrolled for future cardiovascular events in Taiwan. All the patients had received coronary interventions and were stable for least 1 month before enrolment. The incidence of ischaemic stroke was identified and confirmed by telephone and hospital records. Baseline characterist...
Source: Atherosclerosis - January 20, 2022 Category: Cardiology Authors: Wei-Ting Wang Tao-Cheng Wu Wei-Kung Tseng Yen-Wen Wu Tsung-Hsien Lin Hung-I Yeh Kuan-Cheng Chang Ji-Hung Wang Hsin-Bang Leu Wei-Hsian Yin Chau-Chung Wu Jaw-Wen Chen Source Type: research

Renal Function-Dependent Associations of Statins with Outcomes of Ischemic Stroke.
CONCLUSIONS: In patients with acute ischemic stroke, the associations of statins with mortality and functional outcomes was dependent on eGFR. PMID: 32418948 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - May 20, 2020 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Efficacy and Safety of High-intensity Statins in Patients with Acute Myocardial Infarction: An Asian Perspective
ConclusionsAMI patients in Taiwan with HIS had similar clinical outcomes to those with non-HIS. Using HIS for effective reduction of low-density lipoprotein cholesterol is safe in Taiwan.
Source: Canadian Journal of Cardiology - November 2, 2019 Category: Cardiology Source Type: research

Statin adherence and persistence on secondary prevention of cardiovascular disease in Taiwan
Conclusions Good adherence and persistence to statin therapy are significantly associated with lower risk of secondary ASCVD rehospitalisation and in-hospital death.
Source: Heart Asia - September 2, 2019 Category: Cardiology Authors: Shau, W.-Y., Lai, C.-L., Huang, S.-T., Chen, S.-T., Li, J. Z., Fung, S., Tse, V. C., Lai, M.-S. Tags: Original research Source Type: research

Relationship between Statin Use and Outcomes in Patients Having Cardiac Arrest (From a Nationwide Cohort Study in Taiwan)
The objective of this study was to investigate the effects of statin use before cardiac arrest on outcomes in cardiac arrest patients. Medical records of 142,131 adult patients who experienced non-traumatic cardiac arrest and were resuscitated between 2004 and 2011 were analyzed.
Source: The American Journal of Cardiology - February 22, 2019 Category: Cardiology Authors: Chien-Hua Huang, Ping-Hsun Yu, Min-Shan Tsai, Hui-Chun Huang, Tzung-Dau Wang, Wei-Tien Chang, Chao-Hsiun Tang, Wen-Jone Chen Source Type: research

Low Cholesterol Levels Increase Symptomatic Intracranial Hemorrhage Rates After Intravenous Thrombolysis: A Multicenter Cohort Validation Study.
CONCLUSIONS: This study supports the strong association between reduced LDL-C and increased SICH, but not for functional outcomes in patients with acute ischemic stroke treated with intravenous thrombolysis. LDL-C level of ＜130 mg/dL is supposed to a candidate marker for predicting SICH within 24-36 h. PMID: 30464112 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - November 24, 2018 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research