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Identification of magnetic resonance imaging features for the prediction of unrecognized atrial fibrillation in acute ischemic stroke
Conclusion Initial MRI at the time of stroke may be useful to predict which patients have cardioembolic stroke caused by unrecognized AF. Further studies are warranted to verify these findings and their application to high-risk patients.
Source: Frontiers in Neurology - September 13, 2022 Category: Neurology Source Type: research

The Outcome of Status Epilepticus and Long-Term Follow-Up
Conclusion: This study highlights the importance of regular care and patient follow-up. Introduction Status epilepticus (SE) is a condition and most extreme form of epilepsy (1), which leads to abnormal and prolonged seizure (at least 5 min). In case SE persists over 30 min, it may have severe long-term consequences (2). Referring to the new classification scheme of SE, there are two operational dimensions of the definition: time point 1 (T1) is associated with abnormally prolonged seizure, when therapy should be initiated, while time point 2 (T2) is related to the time of on-going seizure activity involving a risk...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Combination of Dexmedetomidine and Ketamine for Magnetic Resonance Imaging Sedation
Conclusions: The efficacy of DEX–KET sedation was comparable to that of midazolam for MRI examination. DEX–KET was related to shorter scan time and lower occurrence of complications compared to midazolam. Introduction Neurocritically ill patients often require brain magnetic resonance imaging (MRI) in addition to conventional neurological evaluations. Brain MRI can reveal structural lesions with a high sensitivity due to its excellent spatial resolution and enhanced soft tissue contrast (1–3). To acquire MRI images, patients' cooperation is imperative. However, keeping patients with ...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

Decompressive Craniectomy for Traumatic Brain Injury: Postoperative Cerebral Hemodynamic Evaluation
Conclusion: There is a wide heterogeneity of postoperative cerebral hemodynamic findings among TBI patients who underwent DC, including hemodynamic heterogeneity between their cerebral hemispheres. DC was proved to be effective for the treatment of cerebral oligoemia. Our data support the concept of heterogeneous nature of the pathophysiology of the TBI and suggest that DC as the sole treatment modality is insufficient. Introduction Decompressive craniectomy (DC) may effectively decrease intracranial pressure (ICP) and increase cerebral perfusion pressure (CPP) in traumatic brain injury (TBI) patients with refracto...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

Decompressive Craniectomy for Traumatic Brain Injury: Postoperative TCD Cerebral Hemodynamic Evaluation
Conclusion: There is a wide heterogeneity of postoperative cerebral hemodynamic findings among TBI patients who underwent DC, including hemodynamic heterogeneity between their cerebral hemispheres. DC was proved to be effective for the treatment of cerebral oligoemia. Our data support the concept of heterogeneous nature of the pathophysiology of the TBI and suggest that DC as the sole treatment modality is insufficient. Introduction Decompressive craniectomy (DC) may effectively decrease intracranial pressure (ICP) and increase cerebral perfusion pressure (CPP) in traumatic brain injury (TBI) patients with refracto...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

Development of a cerebrovascular magnetic resonance imaging biomarker for cognitive aging
ObjectiveRecent availability of amyloid and tau positron emission tomography (PET) has provided us with a unique opportunity to measure the association of systemic vascular health with brain health after accounting for the impact of Alzheimer disease (AD) pathologies. We wanted to quantify early cerebrovascular health –related magnetic resonance imaging brain measures (structure, perfusion, microstructural integrity) and evaluate their utility as a biomarker for cerebrovascular health.MethodsWe used 2 independent samples (discovery, n  = 390; validation, n = 1,035) of individuals, aged ≥ 60 years, along the...
Source: Annals of Neurology - October 25, 2018 Category: Neurology Authors: Prashanthi Vemuri, Timothy G. Lesnick, Scott A. Przybelski, Jonathan Graff ‐Radford, Robert I. Reid, Val J. Lowe, Samantha M. Zuk, Matthew L. Senjem, Christopher G. Schwarz, Jeffrey L. Gunter, Kejal Kantarci, Mary M. Machulda, Michelle M. Mi Tags: Research Article Source Type: research

The Relationship Between Bone Mineral Density and Cardiovascular Function in Duchenne Muscular Dystrophy: A Retrospective Cohort Study
In this study, we explored the relationship between BMD and cardiovascular health, and observed no association between BMD and LVEF. The primary results were in the opposite direction than the hypothesized direction, with the model beta coefficient for BMD indicating a negative relationship with LVEF; however, the size of the effect BMD had on LVEF was very small and not statistically significant. The secondary linear regression analyses provided consistent results with the primary linear regression, indicating that the primary results are sensitive to a variety of slightly modified conditions. It is possible that the nul...
Source: PLOS Currents Muscular Dystrophy - March 22, 2018 Category: Neurology Authors: Tara Anne Kervin Source Type: research

Age, vascular health, and Alzheimer disease biomarkers in an elderly sample
ObjectiveTo investigate the associations between age, vascular health, and Alzheimer disease (AD) imaging biomarkers in an elderly sample. MethodsWe identified 430 individuals along the cognitive continuum aged >60 years with amyloid positron emission tomography (PET), tau PET, and magnetic resonance imaging (MRI) scans from the population‐based Mayo Clinic Study of Aging. A subset of 329 individuals had fluorodeoxyglucose (FDG) PET. We ascertained presently existing cardiovascular and metabolic conditions (CMC) from health care records and used the summation of presence/absence of hypertension, hyperlipidemia, cardia...
Source: Annals of Neurology - October 26, 2017 Category: Neurology Authors: Prashanthi Vemuri, Timothy G. Lesnick, Scott A. Przybelski, David S. Knopman, Val J. Lowe, Jonathan Graff ‐Radford, Rosebud O. Roberts, Michelle M. Mielke, Mary M. Machulda, Ronald C. Petersen, Clifford R. Jack Tags: Research Article Source Type: research

Age, Vascular Health, and Alzheimer's disease Biomarkers in an Elderly Sample
This article is protected by copyright. All rights reserved.
Source: Annals of Neurology - October 10, 2017 Category: Neurology Authors: Prashanthi Vemuri, Timothy G. Lesnick, Scott A. Przybelski, David S. Knopman, Val J. Lowe, Jonathan Graff ‐Radford, Rosebud O. Roberts, Michelle M. Mielke, Mary M. Machulda, Ronald C. Petersen, Clifford R. Jack Tags: Research Article Source Type: research

Beta ‐blocker therapy is not associated with mortality after intracerebral hemorrhage
ConclusionPre‐admission use of BB was not associated with mortality after ICH.
Source: Acta Neurologica Scandinavica - September 4, 2017 Category: Neurology Authors: M. Sykora, J. Putaala, A. Meretoja, T. Tatlisumak, D. Strbian Tags: ORIGINAL ARTICLE Source Type: research

Risks of atrial fibrillation and death at discharge after thrombolysis in stroke patients: Northumbrian Sentinel Stroke Audit, 2013–2015
ConclusionFor future research, clinical outcomes in addition to atrial fibrillation and quality of life both at discharge and 6 months after thrombolysis treatment should be included for examination as well. For clinical practice, giving thrombolysis treatment in hospitals might need to be reconsidered if clinical outcomes were actually worse than not.
Source: Acta Neurologica Scandinavica - April 13, 2016 Category: Neurology Authors: I. Shiue Tags: Clinical Commentary Source Type: research

Risk Factors for Blood-Brain Barrier Disruption in Patients with Chronic Cerebrovascular Disease Presenting with Acute Stroke (P2.245)
Conclusions: These findings suggest that cWMD caused by chronic hypertension may have a different underlying pathophysiology than cWMD that is associated with aging.Disclosure: Dr. Gupta has nothing to disclose. Dr. Luby has nothing to disclose. Dr. Nadareishvili has nothing to disclose. Dr. Benson has nothing to disclose. Dr. Hsia has nothing to disclose. Dr. Lynch has nothing to disclose. Dr. Leigh has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Gupta, N., Luby, M., Nadareishvili, Z., Benson, R., Hsia, A., Lynch, J., Leigh, R. Tags: Aging and Dementia: Other Source Type: research

National registry‐based case–control study: comorbidity and stroke in young adults
ConclusionsIn addition to vascular risk factors, comorbidity (represented by ICD‐10 chapters) was associated with increased risk of stroke in young individuals. The risk of stroke was further increased with the number of diagnosed ICD‐10 chapters.
Source: Acta Neurologica Scandinavica - February 14, 2015 Category: Neurology Authors: E.‐M. Bergman, K. M. Henriksson, S. Åsberg, B. Farahmand, A. Terént Tags: Original Article Source Type: research

"No Turn Back Approach" to Reduce Treatment Time for Endovascular Treatment of Acute Ischemic Stroke (P4.214)
Conclusions: The "no turn back approach" appeared to be feasible and reduced the time interval between ED arrival and microcatheter placement in acute ischemic stroke patients undergoing endovascular treatment.Disclosure: Dr. Egila has nothing to disclose. Dr. Malik has nothing to disclose. Dr. Siddiqi has nothing to disclose. Dr. Mian has nothing to disclose. Dr. Hassan has nothing to disclose. Dr. Miley has nothing to disclose. Dr. Rodriguez has nothing to disclose. Dr. Suri has nothing to disclose. Dr. Qureshi has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Egila, H., Adil, M., Siddiqi, H., Mian, N., Hassan, A., Miley, J., Rodriguez, G., Suri, M., Qureshi, A. Tags: Cerebrovascular Disease and Interventional Neurology: Acute Stroke Endovascular Source Type: research

“No Turn Back Approach” to Reduce Treatment Time for Endovascular Treatment of Acute Ischemic Stroke
Conclusions: The no turn back approach appeared to be feasible and reduced the time interval between ED arrival and microcatheter placement in acute ischemic stroke patients undergoing endovascular treatment.
Source: Journal of Stroke and Cerebrovascular Diseases - February 21, 2014 Category: Neurology Authors: Adnan I. Qureshi, Hossam Egila, Malik M. Adil, Harris Siddiqi, Nidaullah Mian, Ameer E. Hassan, Jefferson T. Miley, Gustavo J. Rodriguez, M. Fareed K. Suri Tags: Original Articles Source Type: research

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