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Hypertrophic Cardiomyopathy: New Concepts and Therapies
Annu Rev Med. 2022 Jan 27;73:363-375. doi: 10.1146/annurev-med-042220-021539.ABSTRACTHypertrophic cardiomyopathy (HCM), a relatively common, globally distributed, and often inherited myocardial disorder, transformed over the last several years into a treatable condition with the emergence of effective management options that alter natural history at all ages. Now available are a matured risk stratification algorithm selecting patients for prophylactic implantable defibrillators that prevent arrhythmic sudden death; low-risk, high-benefit surgical myectomy to reverse progressive heart failure symptoms due to left ventricula...
Source: Annual Review of Medicine - January 27, 2022 Category: General Medicine Authors: Barry J Maron Ethan J Rowin Martin S Maron Source Type: research

Stroke epidemiology and outcomes in the modern era of left ventricular assist devices
AbstractThe care for the patients with end-stage heart failure has been revolutionized by the introduction of durable left ventricular assist devices, providing a substantial improvement in patient survival and quality of life and an alternative to heart transplantation. The newest devices have lower instances of mechanical dysfunction and associated pump thrombosis. Despite these improvements in complications, the use of continuous flow assist devices is still associated with high rates of thrombotic and hemorrhagic complications, most notably stroke in approximately 10% of continuous flow assist devices patients per year...
Source: Heart Failure Reviews - January 16, 2022 Category: Cardiology Source Type: research

Mid-Term Outcomes of Heart Transplantation in Children with Genetic Disorders
CONCLUSIONS: Despite more preoperative comorbidities, mid-term outcomes following heart transplant in children with genetic syndromes and disorders are promising.PMID:35007503 | DOI:10.1016/j.athoracsur.2021.12.019
Source: The Annals of Thoracic Surgery - January 10, 2022 Category: Cardiovascular & Thoracic Surgery Authors: Horacio G Carvajal Catherine Gooch Taylor C Merritt J Chancellor Fox Anne N Pourney Harshini D Kumaresan Matthew W Canter Pirooz Eghtesady Source Type: research

Prognostic Importance of Pulmonary Artery Pulsatility Index and Right Ventricular Stroke Work Index in End-Stage Heart Failure Patients
Conclusion: The low PAPi was an ind ependent risk for ACE and it had a linear association with it. However, RVSWI seems to be have a nonlinear association with ACE (J-curve pattern).
Source: Cardiology - January 3, 2022 Category: Cardiology Source Type: research

Myocardial infarction and factor VIII elevation in a 36-year-old man
We report a 36-year-old man who had a myocardial infarction despite lacking traditional cardiac risk factors. He developed end-stage heart failure and renal insufficiency necessitating a HeartMate II left ventricular assist device (LVAD). While on the transplant list, he experienced two episodes of LVAD thrombosis 6 months apart, prompting device exchange and escalation of anticoagulation therapy. He eventually underwent a successful heart-kidney transplant before suffering an extensive left lower extremity deep vein thrombosis 6 weeks later. A thrombophilia workup revealed elevated factor VIII activity of 319% (normal ran...
Source: Baylor University Medical Center Proceedings - December 31, 2021 Category: Universities & Medical Training Authors: Amit Alam Harsh Doshi Divya N Patel Keval Patel Dreamy James Jesus Almendral Source Type: research

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