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Sleep Apnea and the Effects on Your Health
Sleep is not always a benign state. Snoring may not be harmless. In fact, a related condition that affects breathing during sleep may have important consequences. This disorder, sleep apnea, can have significant effects on your overall health. There are certain symptoms and signs associated with obstructive sleep apnea that can affect day-to-day life. Excessive daytime sleepiness, mood complaints like anxiety or depression, or difficulty with thinking may undermine concentration or memory. However, untreated sleep apnea can have other unwanted side effects. Sleep apnea may increase blood pressure, lead to insulin resista...
Source: About Sleep Disorders - March 21, 2014 Category: Sleep Medicine Source Type: news

Obstructive sleep apnea increases the risk of cardiac events after percutaneous coronary intervention: a meta-analysis of prospective cohort studies.
CONCLUSIONS: In patients after PCI, OSA appears to increase the risk of cardiac death, non-fatal MI, and coronary revascularization. PMID: 28421375 [PubMed - as supplied by publisher]
Source: Sleep and Breathing - April 18, 2017 Category: Sleep Medicine Authors: Qu H, Guo M, Zhang Y, Shi DZ Tags: Sleep Breath Source Type: research

Sleep Apnea Cardiovascular Clinical Trials—Current Status and Steps Forward: The International Collaboration of Sleep Apnea Cardiovascular Trialists
This article summarizes the status of clinical trials evaluating the potential cardiovascular benefits of sleep apnea treatment and discusses the challenges of conducting such trials, and introduces the International Collaboration of Sleep Apnea Cardiovascular Trialists (INCOSACT), a clinical research collaboration formed to foster cardiovascular sleep research.Citation:Gottlieb DJ; Craig SE; Lorenzi-Filho G; Heeley E; Redline S; McEvoy RD; Durán-Cantolla J. Sleep apnea cardiovascular clinical trials— current status and steps forward: the International Collaboration of Sleep Apnea Cardiovascular Trialists. SLE...
Source: Sleep - July 2, 2013 Category: Sleep Medicine Source Type: research

The effect of continuous positive airway pressure therapy on vascular function in obstructive sleep apnea: how much is enough?
Over the last two decades, obstructive sleep apnea (OSA) has emerged as a considerable public health burden. Due to the ongoing epidemic of obesity, which is strongly linked to OSA, the prevalence of the disease has been steadily rising. According to recent data from the Wisconsin Sleep Cohort, the combination of sleep-disordered breathing as indicated by an apnea–hypopnea index of>5 events per hour and excessive daytime sleepiness occurs in approximately 14% of men and 5% of women between the ages of 30 and 70years . Cardiovascular diseases (CVDs) represent the principal morbidity and mortality in OSA and large-scale ep...
Source: Sleep Medicine - November 8, 2013 Category: Sleep Medicine Authors: Silke Ryan Tags: Editorials Source Type: research

Excessive Daytime Sleepiness is Associated with Longer Culprit Lesion and Adverse Outcomes in Patients with Coronary Artery Disease
Conclusion:In patients presenting with coronary artery disease, excessive daytime sleepiness based on ESS > 10 was associated with longer culprit lesions and future adverse cardiovascular events.Citation:Lee CH; Ng WY; Hau W; Ho HH; Tai BC; Chan MY; Richards AM; Tan HC. Excessive daytime sleepiness is associated with longer culprit lesion and adverse outcomes in patients with coronary artery disease. J Clin Sleep Med 2013;9(12):1267-1272.
Source: Journal of Clinical Sleep Medicine : JCSM - December 14, 2013 Category: Sleep Medicine Source Type: research

Influence and Predicting Variables of Obstructive Sleep Apnea on Cardiac Function and Remodeling in Patients without Congestive Heart Failure
Conclusions:Patients with moderate to severe OSAS tend to have cardiac dysfunction revealed by echocardiography. High AHI in REM sleep is significantly associated with cardiovascular remodeling and ventricular diastolic dysfunction, and may be a potential variable to predict cardiac dysfunction.Citation:Chen YL; Su MC; Liu WH; Wang CC; Lin MC; Chen MC. Influence and predicting variables of obstructive sleep apnea on cardiac function and remodeling in patients without congestive heart failure. J Clin Sleep Med 2014;10(1):57-64.
Source: Journal of Clinical Sleep Medicine : JCSM - January 14, 2014 Category: Sleep Medicine Source Type: research

Sleep Impairment and Prognosis of Acute Myocardial Infarction: A Prospective Cohort Study
Conclusion:Results suggest sex-specific effects of impaired sleep that differ by short- and long-term prognosis. Sleep complaints are frequent, easily recognizable, and potentially manageable. Evaluation of sleep complaints may, even if they represent prognostic markers rather than risk factors, provide additional information in clinical risk assessment that could benefit secondary cardiovascular prevention.Citation:Clark A, Lange T, Hallqvist J, Jennum P, Rod NH. Sleep impairment and prognosis of acute myocardial infarction: a prospective cohort study. SLEEP 2014;37(5):851-858.
Source: Sleep - May 1, 2014 Category: Sleep Medicine Source Type: research

Obstructive sleep apnea research: challenges and new horizons
Badran et al. provide an overview of insights into obstructive sleep apnea (OSA) research with a focus on cardiovascular-specific areas including hypertension, diabetes mellitus, coronary artery disease, stroke and heart failure, and updates of the role of oxidative stress, systemic inflammation and endothelial dysfunction as intermediate pathways. A discussion on the role of experimental animal models to enhance the elucidation of underlying mechanistic pathways is also provided, particularly in terms of isolating the unique effects of specific OSA-related pathophysiologic processes including models of upper airway occlus...
Source: Sleep Medicine - April 7, 2014 Category: Sleep Medicine Authors: Reena Mehra Tags: Editorials Source Type: research

Prognostic implication of obstructive sleep apnea diagnosed by post-discharge sleep study in patients presenting with acute coronary syndrome
Conclusion: OSA diagnosed in patients treated with percutaneous coronary intervention for ACS by post-discharge sleep studies conducted 2weeks after percutaneous coronary intervention was independently associated with MACCEs at 24-month follow-up.
Source: Sleep Medicine - April 14, 2014 Category: Sleep Medicine Authors: Germaine Loo, Adeline Y. Tan, Chieh-Yang Koo, Bee-Choo Tai, Mark Richards, Chi-Hang Lee Tags: Original Articles Source Type: research

Diurnal and Twenty-Four-Hour Patterning of Human Diseases: Cardiac, Vascular, and Respiratory Diseases, Conditions, and Syndromes
Various medical conditions, disorders, and syndromes exhibit predictable-in-time diurnal and 24-hour patterning in the signs, symptoms, and grave nonfatal and fatal events, e.g., respiratory ones of viral and allergic rhinorrhea, reversible (asthma) and non-reversible (bronchitis and emphysema) chronic obstructive pulmonary disease, cystic fibrosis, high altitude pulmonary edema, and decompression sickness; cardiac ones of atrial premature beats and tachycardia, paroxysmal atrial fibrillation, 3rd degree atrial-ventricular block, paroxysmal supraventricular tachycardia, ventricular premature beats, ventricular tachyarrhyth...
Source: Sleep Medicine Reviews - July 18, 2014 Category: Sleep Medicine Authors: Michael H. Smolensky, Francesco Portaluppi, Roberto Manfredini, Ramon C. Hermida, Ruana Tiseo, Linda L. Sackett-Lundeen, Erhard Haus Source Type: research

Heart rate variability and cardiorespiratory coupling in obstructive sleep apnea: elderly compared with young
Obstructive sleep apnea (OSA) is a respiratory disorder characterized by recurrent airflow obstruction caused by total or partial collapse of the upper airways [1,2]. Aging is associated with increased apnea prevalence and is thus known to be a major factor contributing to the risk of OSA [3,4]. Moreover, elderly adults with OSA are at greater risk for cardiovascular disease (i.e. coronary artery disease, congestive heart failure, ischemic disease, and stroke) [5,6].
Source: Sleep Medicine - June 27, 2014 Category: Sleep Medicine Authors: R. Trimer, R. Cabidu, L.L.M. Sampaio, R. Stirbulov, D. Poiares, S. Guizilini, A.M. Bianchi, F.S.M. Costa, R.G. Mendes, A. Delfino, R. Arena, A. Borghi-Silva Tags: Original Article Source Type: research

Diurnal and twenty-four hour patterning of human diseases: Cardiac, vascular, and respiratory diseases, conditions, and syndromes
Various medical conditions, disorders, and syndromes exhibit predictable-in-time diurnal and 24 h patterning in the signs, symptoms, and grave nonfatal and fatal events, e.g., respiratory ones of viral and allergic rhinorrhea, reversible (asthma) and non-reversible (bronchitis and emphysema) chronic obstructive pulmonary disease, cystic fibrosis, high altitude pulmonary edema, and decompression sickness; cardiac ones of atrial premature beats and tachycardia, paroxysmal atrial fibrillation, 3rd degree atrial-ventricular block, paroxysmal supraventricular tachycardia, ventricular premature beats, ventricular tachyarrhythm...
Source: Sleep Medicine Reviews - July 18, 2014 Category: Sleep Medicine Authors: Michael H. Smolensky, Francesco Portaluppi, Roberto Manfredini, Ramon C. Hermida, Ruana Tiseo, Linda L. Sackett-Lundeen, Erhard L. Haus Tags: Clinical review Source Type: research

Self-reported obstructive sleep apnea, simple snoring, and various markers of sleep-disordered breathing as predictors of cardiovascular risk.
CONCLUSIONS: Self-reported OSA and SDB-related snoring variables are associated with cardiovascular risk, whereas simple snoring is not. In clinical practice and in surveys, questions concerning only habitual snoring should be amended with questions focusing on respiratory pauses and snoring stertorousness, which can be used to estimate the risk of OSA and cardiovascular events. PMID: 26363577 [PubMed - as supplied by publisher]
Source: Sleep and Breathing - September 12, 2015 Category: Sleep Medicine Authors: Niiranen TJ, Kronholm E, Rissanen H, Partinen M, Jula AM Tags: Sleep Breath Source Type: research

The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methods.
CONCLUSIONS: This manuscript provides the rationale for the inclusion of veterans in a study to determine the association between physiologic sleep measures and cardiovascular outcomes and specifically the development of a corresponding outcome-based prognostic model. PMID: 26642771 [PubMed - as supplied by publisher]
Source: Sleep and Breathing - December 7, 2015 Category: Sleep Medicine Authors: Koo BB, Won C, Selim BJ, Qin L, Jeon S, Redeker NS, Bravata DM, Strohl KP, Concato J, Yaggi HK Tags: Sleep Breath Source Type: research

Obstructive sleep apnea is independently associated with subclinical coronary atherosclerosis among middle-aged women.
CONCLUSION: Moderate to severe OSA is independently associated with the presence of CAC in middle-aged women. These results reinforce the concept that women are also susceptible to the cardiovascular consequences of OSA. PMID: 27384043 [PubMed - as supplied by publisher]
Source: Sleep and Breathing - July 5, 2016 Category: Sleep Medicine Authors: Medeiros AK, Coutinho RQ, Barros IM, Costa LO, Leite AP, Bittencourt MS, Lustosa TC, Carvalho MM, Lira MP, Ferreira MN, Lorenzi-Filho G, Drager LF, Pedrosa RP Tags: Sleep Breath Source Type: research

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