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Condition: Heart Failure
Nutrition: Vitamins

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Total 268 results found since Jan 2013.

The VitDISH Study: Vit D Supplementation Does Not Improve ISH in Older Patients
Low vitamin D levels have been associated with stroke and heart failure and studies of supplementation suggest a salutatory effect on hypertension in some patients. Here, more data to consider but no final conclusions.
Source: Consultant Live - October 9, 2013 Category: Primary Care Source Type: news

Vitamin K antagonists in heart disease: Current status and perspectives (Section III). Position Paper of the ESC Working Group on Thrombosis - Task Force on Anticoagulants in Heart Disease.
Abstract Oral anticoagulants are a mainstay of cardiovascular therapy, and for over 60 years vitamin K antagonists (VKAs) were the only available agents for long-term use. VKAs interfere with the cyclic inter-conversion of vitamin K and its 2,3 epoxide, thus inhibiting γ-carboxylation of glutamate residues at the amino-termini of vitamin K-dependent proteins, including the coagulation factors (F) II (prothrombin), VII, IX and X, as well as of the anticoagulant proteins C, S and Z. The overall effect of such interference is a dose-dependent anticoagulant effect, which has been therapeutically exploited in heart di...
Source: Thrombosis and Haemostasis - November 14, 2013 Category: Hematology Authors: De Caterina R, Husted S, Wallentin L, Andreotti F, Arnesen H, Bachmann F, Baigent C, Huber K, Jespersen J, Kristensen SD, Lip GY, Morais J, Rasmussen LH, Siegbahn A, Verheugt FW, Weitz JI Tags: Thromb Haemost Source Type: research

Zimbabwe: Contaminated BP Drug Recalled
[The Herald]Local pharmacies have removed Brinerdin, a drug used to treat hypertension, from their shelves after it was recently recalled by its Swiss manufacturer - Novartis - to ensure compliance with regulatory standards and quality control.The withdrawal of Brinerdin from the local market came amid indications that the drug caused severe side-effects such as kidney malfunction, ulcers, stroke, heart failure and depletes vitamins.
Source: AllAfrica News: Health and Medicine - December 24, 2013 Category: African Health Source Type: news

A prospective survey in European Society of Cardiology member countries of atrial fibrillation management: baseline results of EURObservational Research Programme Atrial Fibrillation (EORP-AF) Pilot General Registry
Conclusion The EURObservational Research Programme Atrial Fibrillation (EORP-AF) Pilot Registry has provided systematic collection of contemporary data regarding the management and treatment of AF by cardiologists in ESC member countries. Oral anticoagulant use has increased, but novel OAC use was still low. Compliance with the treatment guidelines for patients with the lowest and higher stroke risk scores remains suboptimal.
Source: Europace - February 25, 2014 Category: Cardiology Authors: Lip, G. Y. H., Laroche, C., Dan, G.-A., Santini, M., Kalarus, Z., Rasmussen, L. H., Oliveira, M. M., Mairesse, G., Crijns, H. J. G. M., Simantirakis, E., Atar, D., Kirchhof, P., Vardas, P., Tavazzi, L., Maggioni, A. P. Tags: Atrial fibrillation Source Type: research

Vitamin D Deficiency and Cardiovascular Events in Patients With Coronary Heart Disease: Data From the Heart and Soul Study
A growing body of evidence supports an association between vitamin D and cardiovascular disease. However, the mechanisms underlying this association are unknown. From 2000 to 2002, we identified 946 participants with stable cardiovascular disease in San Francisco, California, and followed them prospectively for cardiovascular events (heart failure, myocardial infarction, stroke, or cardiovascular death). We then examined the extent to which the association was attenuated by adjustment for poor health behaviors, comorbid health conditions, and potential biological mediators. During a median follow-up period of 8.0 years (th...
Source: American Journal of Epidemiology - May 27, 2014 Category: Epidemiology Authors: Welles, C. C., Whooley, M. A., Karumanchi, S. A., Hod, T., Thadhani, R., Berg, A. H., Ix, J. H., Mukamal, K. J. Tags: RESEARCH-ARTICLE Source Type: research

In women, increased dietary antioxidants are associated with reduced risk of developing heart failure
Commentary on Rautiainen S, Levitan EB, Mittleman MA, et al.. Total antioxidant capacity of diet and risk of heart failure: a population-based prospective cohort of women. Am J Med 2013;126:494–500. Implications for practice and research A diet rich in natural antioxidants may reduce the risk of developing heart failure. Well-designed intervention studies are needed to investigate the effect of a diet rich in antioxidants on heart failure incidence. Context Heart failure is a syndrome comprising symptoms such as breathlessness alongside objective evidence of cardiac dysfunction. This is a common condition with a cons...
Source: Evidence-Based Nursing - June 17, 2014 Category: Nursing Authors: McKeown, P., McKeag, N. Tags: Drugs: cardiovascular system, Heart failure, Stroke, Diet, Vitamins and supplements, Ischaemic heart disease, Diabetes, Medical humanities, Alcohol, Health education, Smoking, Health effects of tobacco use, Tobacco use Women ' s health Source Type: research

Parathyroid hormone concentration and risk of cardiovascular diseases: The Atherosclerosis Risk in Communities (ARIC) study
Conclusions: This large prospective study failed to support the hypothesis that elevated PTH is an independent risk marker for incident CVD. When our data were added to the previous meta-analysis, the pooled hazard ratio remained statistically significant but weakened.
Source: American Heart Journal - June 11, 2014 Category: Cardiology Authors: Aaron R. Folsom, Alvaro Alonso, Jeffrey R. Misialek, Erin D. Michos, Elizabeth Selvin, John H. Eckfeldt, Josef Coresh, James S. Pankow, Pamela L. Lutsey Tags: Coronary Artery Disease Source Type: research

Incidence of myocardial infarction and vascular death in anticoagulated elderly patients with atrial fibrillation: Relation to atherosclerotic risk factors.
CONCLUSIONS: AF patients still experience a high rate of CVEs despite being on anticoagulant treatment. MetS is a common clinical feature in AF patients, which increases the risk of CVEs. A holistic approach is needed to reduce the risk of cardiovascular risk in patients with AF. Clinical Trial Registration: ClinicalTrials.gov NCT01882114. PMID: 25429521 [PubMed - as supplied by publisher]
Source: Chest - November 27, 2014 Category: Respiratory Medicine Authors: Pastori D, Pignatelli P, Angelico F, Farcomeni A, Del Ben M, Vicario T, Bucci T, Raparelli V, Cangemi R, Tanzilli G, Lip GY, Violi F Tags: Chest Source Type: research

Sex-related differences in presentation, treatment, and outcome of patients with atrial fibrillation in Europe: a report from the Euro Observational Research Programme Pilot survey on Atrial Fibrillation
Conclusion The EORP-AF Pilot survey provides contemporary data on sex differences in clinical features and management of AF patients participating in the EORP-AF Pilot registry. Female subjects were older and more symptomatic, compared with males, and were more likely to receive rate control. Also, female patients were at higher stroke risk overall, but oral anticoagulation was used in a high proportion of patients.
Source: Europace - December 31, 2014 Category: Cardiology Authors: Lip, G. Y. H., Laroche, C., Boriani, G., Cimaglia, P., Dan, G.-A., Santini, M., Kalarus, Z., Rasmussen, L. H., Popescu, M. I., Tica, O., Hellum, C. F., Mortensen, B., Tavazzi, L., Maggioni, A. P. Tags: Atrial fibrillation Source Type: research

Effects of Sleepiness on Survival in Japanese Hemodialysis Patients: J-DOPPS Study
Sleep disorder and poor sleep quality are common in chronic hemodialysis (HD) patients. They have been claimed as a cause of morbidity and mortality. The relationship between the degree of sleepiness and survival has not been studied. We studied the degree of sleepiness in 1,252 adult HD patients (age ≥20 years) recruited into the Dialysis Outcomes Practice Pattern Study in Japan (J-DOPPS III), using the Japanese version of the Epworth Sleepiness Scale (JESS) questionnaire. Demographic data were presented for three subgroups: low, intermediate, and high JESS score. Cox proportional hazard regression analysis was performe...
Source: Nephron Clinical Practice - January 8, 2015 Category: Urology & Nephrology Source Type: research

Anticoagulation therapy in 2015: where we are and where we are going
Abstract Oral anticoagulants are a mainstay for the prevention and treatment of venous and arterial thrombosis. In 2015, the non-vitamin K oral anticoagulants (NOACs) are already replacing warfarin for many indications. Ongoing studies are focused on development of antidotes and specific reversal agents for the NOACs, and assessing their utility for prevention of cardiovascular events in patients with heart failure, coronary or peripheral artery disease, or embolic stroke of unknown source. This paper (a) lists the current indications for the NOACs; (b) reviews the current impact of the NOACs in each of these indi...
Source: Journal of Thrombosis and Thrombolysis - February 19, 2015 Category: Hematology Source Type: research

Drug persistence with rivaroxaban therapy in atrial fibrillation patients--results from the Dresden non-interventional oral anticoagulation registry
Conclusion Our data indicate that overall persistence with rivaroxaban therapy is high, with a discontinuation rate of ~15% in the first year of treatment and few additional discontinuations thereafter.
Source: Europace - April 1, 2015 Category: Cardiology Authors: Beyer-Westendorf, J., Forster, K., Ebertz, F., Gelbricht, V., Schreier, T., Gobelt, M., Michalski, F., Endig, H., Sahin, K., Tittl, L., Weiss, N. Tags: Atrial fibrillation Source Type: research

Antithrombotic Therapy for Left Ventricular Assist Devices in Adults: a Systematic Review
ConclusionsOf 977 manuscripts, 24 articles met the inclusion criteria of adults with implanted LVADs where clinical outcomes were defined based on anticoagulant and/or antiplatelet regimen. Most studies reported treatment with unfractionated heparin post‐operatively which was transitioned to a vitamin K antagonist (VKA). Goal INR varied between 1.5‐3.5. Antiplatelet regimens ranged from no treatment to dual therapy. Definition of major bleeding differed between trials and incidence varied between 0% and 58%. The available evidence could not demonstrate a clear benefit of aspirin compared with VKA therapy alone [stroke...
Source: Journal of Thrombosis and Haemostasis - April 6, 2015 Category: Hematology Authors: Lisa Baumann Kreuziger, Benjamin Kim, Georg M. Wieselthaler Tags: Review Article Source Type: research

Antithrombotic Therapy for Left Ventricular Assist Devices in Adults: a Systematic Review.
CONCLUSIONS: Of 977 manuscripts, 24 articles met the inclusion criteria of adults with implanted LVADs where clinical outcomes were defined based on anticoagulant and/or antiplatelet regimen. Most studies reported treatment with unfractionated heparin post-operatively which was transitioned to a vitamin K antagonist (VKA). Goal INR varied between 1.5-3.5. Antiplatelet regimens ranged from no treatment to dual therapy. Definition of major bleeding differed between trials and incidence varied between 0% and 58%. The available evidence could not demonstrate a clear benefit of aspirin compared with VKA therapy alone [stroke R...
Source: Thrombosis and Haemostasis - April 6, 2015 Category: Hematology Authors: Kreuziger LB, Kim B, Wieselthaler GM Tags: J Thromb Haemost Source Type: research

Epidemiologic insights on the role of fibroblast growth factor 23 in cardiovascular disease
Purpose of review: Fibroblast growth factor 23 (FGF23) regulates phosphate and vitamin D homeostasis and rises as kidney function declines. Animal studies have demonstrated direct and indirect effects of FGF23 that may promote heart disease. Herein, we review the recent epidemiologic literature evaluating the relationship between FGF23 and cardiovascular disease. Recent findings: In observational prospective studies, higher FGF23 associates with a greater risk of incident cardiovascular disease including ischemic heart disease, stroke, heart failure, and atrial fibrillation. These studies establish a temporal sequence of e...
Source: Current Opinion in Nephrology and Hypertension - April 14, 2015 Category: Urology & Nephrology Tags: EPIDEMIOLOGY AND PREVENTION: Edited by Navdeep Tangri Source Type: research