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Condition: Heart Failure
Nutrition: Calcium
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Total 213 results found since Jan 2013.
MicroRNAs emerging as mediators of remodeling with atrial fibrillation
Atrial fibrillation (AF) is the most common cardiac arrhythmia and is now established as an independent risk factor for stroke. Moreover, a concomitant diagnosis of AF greatly complicates treatment for a number of disease processes such as diabetes and congestive heart failure. Given the recognized additional burden that AF places on the health-care system, significant research has been performed in an attempt to delineate mechanisms that contribute to AF initiation as well as progression. Understandably, there is an extensive body of research that has identified abnormalities in ionic channels/electrogenic processes that ...
Source: Heart Rhythm - March 25, 2013 Category: Cardiology Authors: Adam W. Akerman, Rupak Mukherjee Tags: Editorial Commentary Source Type: research
Characterization of a novel multi‐functional resveratrol derivative for the treatment of atrial fibrillation.
Conclusion and ImplicationsThese findings indicate that C1 is a promising multi‐functional small molecule that targets a number of key pathways involved in AF.
Source: British Journal of Pharmacology - September 17, 2013 Category: Drugs & Pharmacology Authors: Istvan Baczko, David Liknes, Wei Yang, Kevin C Hamming, Gavin Searle, Kristian Jaeger, Zoltan Husti, Viktor Juhasz, Gergely Klausz, Robert Pap, Laszlo Saghy, Andras Varro, Vernon Dolinsky, Shaohua Wang, Vivek Rauniyar, Dennis Hall, Jason R. Dyck, Peter E. Tags: Research Paper Source Type: research
Mediators of Atherosclerosis in South Asians Living in America (MASALA) Study: Objectives, Methods, and Cohort Description
ConclusionsThe MASALA study will provide novel data on the prevalence and associations of cardiovascular risk factors and subclinical atherosclerosis in South Asians living in the United States.
Source: Clinical Cardiology - November 5, 2013 Category: Cardiology Authors: Alka M. Kanaya, Namratha Kandula, David Herrington, Matthew J. Budoff, Stephen Hulley, Eric Vittinghoff, Kiang Liu Tags: Trial Design Source Type: research
Long-term levosimendan treatment improves systolic function and myocardial relaxation in mice with cardiomyocyte-specific disruption of the Serca2 gene
In conclusion, long-term levosimendan treatment improves both contractility and relaxation in a heart-failure model with marked diastolic dysfunction due to reduced calcium transients. However, altered gene expression related to fibrosis was observed.
Source: Journal of Applied Physiology - November 15, 2013 Category: Physiology Authors: Hillestad, V., Kramer, F., Golz, S., Knorr, A., Andersson, K. B., Christensen, G. Tags: ARTICLES Source Type: research
Characterization of a novel multifunctional resveratrol derivative for the treatment of atrial fibrillation
Conclusion and ImplicationsC1 behaved as a promising multifunctional small molecule targeting a number of key pathways involved in AF.
Source: British Journal of Pharmacology - December 10, 2013 Category: Drugs & Pharmacology Authors: Istvan Baczko, David Liknes, Wei Yang, Kevin C Hamming, Gavin Searle, Kristian Jaeger, Zoltan Husti, Viktor Juhasz, Gergely Klausz, Robert Pap, Laszlo Saghy, Andras Varro, Vernon Dolinsky, Shaohua Wang, Vivek Rauniyar, Dennis Hall, Jason RB Dyck, Peter E Tags: RESEARCH PAPER Source Type: research
Levosimendan improves contractility in vivo and in vitro in a rodent model of post‐myocardial infarction heart failure
ConclusionIn HF animals LEV improved the contractility by increasing the Ca2+ sensitivity. Furthermore loading conditions were changed, and LEV could consequently change organ perfusion. An observed increase in diastolic Ca2+ following LEV treatment and clinical implications of this should be further addressed.This article is protected by copyright. All rights reserved.
Source: Acta Physiologica - February 5, 2014 Category: Physiology Authors: Solveig Moss Kolseth, Natale Pinheiro Lage Rolim, Øyvind Salvesen, Dag Ole Nordhaug, Alexander Wahba, Morten Andre Høydal Tags: Regular Paper Source Type: research
U Wave Variability in the Surface ECG
A 72‐year‐old man with heart failure, left ventricular dysfunction (ejection fraction 20%), prior ischemic stroke, COPD, and exacerbation of chronic renal failure was admitted in our unit. Serum potassium was 6.1 mmol/L, calcium concentration was at the lower normal range 2.15 mmol/L, and NT‐pro‐BNP was 28,900 pg/mL. The surface 12‐lead electrocardiogram (ECG) showed sinus rhythm at 60 bpm, PR interval 160 ms, QRS duration 115 ms, QT interval 460 ms, and left ventricular hypertrophy criteria. Negative T waves in leads I, II, aVL, and V4–V6 were also seen. In leads V4–V6, negative U waves were observed in conc...
Source: Annals of Noninvasive Electrocardiology - April 21, 2014 Category: Cardiology Authors: Piotr Kukla, Adrian Baranchuk, Marek Jastrzębski, Leszek Bryniarski Tags: CASE REPORT Source Type: research
Statins do not improve cardiovascular outcomes for dialysis patients
Commentary on: Palmer SC, Navaneethan SD, Craig JC, et al.. HMG CoA reductase inhibitors (statins) for dialysis patients: a systematic review and meta-analysis. Cochrane Database Syst Rev 2013;(9):CD004289. Context Chronic kidney disease affected nearly 19 million people in the USA, with incidence increasing globally at an annual rate of 8%, most of which were unrecognised or undiagnosed. Cardiovascular events are common among patients with chronic kidney disease and highest in dialysis patients. While dialysis patients experience a high prevalence of traditional risk factors for cardiovascular disease (CVD), such as hyper...
Source: Evidence-Based Medicine - May 19, 2014 Category: Internal Medicine Authors: Olyaei, A. Tags: Clinical trials (epidemiology), Epidemiologic studies, Drugs: cardiovascular system, Neuromuscular disease, Stroke, Hypertension, Obesity (nutrition), Ischaemic heart disease, Unwanted effects / adverse reactions, Renal medicine, Musculoskeletal syndromes Source Type: research
Amlodipine and cardiovascular outcomes in hypertensive patients: meta-analysis comparing amlodipine-based versus other antihypertensive therapy.
CONCLUSIONS: Amlodipine reduced the risk of total cardiovascular events as well as all-cause mortality compared with non-CCB-based regimens, indicating its benefit for high-risk cardiac patients.
PMID: 24851066 [PubMed - in process]
Source: The Korean Journal of Internal Medicine - May 1, 2014 Category: Internal Medicine Authors: Lee SA, Choi HM, Park HJ, Ko SK, Lee HY Tags: Korean J Intern Med Source Type: research
Blood pressure control and cardiovascular outcomes in normal-weight, overweight, and obese hypertensive patients treated with three different antihypertensives in ALLHAT
Objective:Epidemiologically, there is a strong relationship between BMI and blood pressure (BP) levels. We prospectively examined randomization to first-step chlorthalidone, a thiazide-type diuretic; amlodipine, a calcium-channel blocker; and lisinopril, an angiotensin-converting enzyme inhibitor, on BP control and cardiovascular outcomes in a hypertensive cohort stratified by baseline BMI [kg/m2; normal weight (BMI 30)].
Methods:In a randomized, double-blind, practice-based Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial, 33 357 hypertensive participants, aged at least 55 years, were followed...
Source: Journal of Hypertension - June 6, 2014 Category: Cardiology Tags: ORIGINAL PAPERS: Obesity Source Type: research
Comparative Persistence on β-Blockers Versus Calcium Channel Blockers for Ventricular Rate Control in Nonelderly Patients With Atrial Fibrillation.
CONCLUSIONS: Evidence suggests that nonelderly AF patients, when prescribed rate-control therapy, persist longer on BBs than CCBs. Because this is the first long-term study comparing the 2 drug classes in the nonelderly population, further research is suggested.
PMID: 25280975 [PubMed - as supplied by publisher]
Source: The Annals of Pharmacotherapy - October 3, 2014 Category: Drugs & Pharmacology Authors: Desai VC, Kelton CM, Metzger AH, Cavanaugh TM, Guo JJ, Heaton PC Tags: Ann Pharmacother Source Type: research
Challenges in the management of hypertension in Asia
Hypertension is common in Asian populations and is a major cause of cardiovascular diseases. Even a small reduction in blood pressure can lead to a substantial decrease in the risk of stroke. The prevalence of hypertension appears to be increasing in many countries, partly because of ageing of the population, but also because of increasing obesity. While much effort has gone into promoting the awareness of hypertension, the rates of detection, treatment, and control remain low. As hypertension is very prevalent in the general population, it makes sense to adopt population approaches towards the detection and treatment of h...
Source: European Journal of Heart Failure Supplements - February 23, 2012 Category: Cardiology Authors: Cheung, B. M. Y., Cheung, T. T. Tags: Original Articles Source Type: research
Cardiovascular disease in chronic kidney disease
Publication date: January–March 2014 Source:Clinical Queries: Nephrology, Volume 3, Issue 1 Author(s): Shivendra Singh Chronic kidney disease (CKD) is emerging health problem with prevalence of approximately 10% in general population. The incidence and prevalence of cardiovascular disease (CVD) is high in CKD patients, approaching >50% in patients in advance CKD. CVD outcomes are worse in presence of CKD suggesting different pathophysiology compared to general population. Patients with CKD are at increased risk of both atherosclerotic and structural heart disease, stroke and peripheral vascular disease. Congesti...
Source: Clinical Queries: Nephrology - November 1, 2014 Category: Urology & Nephrology Source Type: research
Effects of a myofilament calcium sensitizer on left ventricular systolic and diastolic function in rats with volume overload heart failure
This study investigated myocyte and myofilament function in ACF and REV and tested the hypothesis that a myofilament Ca2+ sensitizer would improve VO-induced myofilament dysfunction in ACF and REV. Following the initial sham or ACF surgery in male Sprague-Dawley rats (200–240 g) at week 0, REV surgery and experiments were performed at weeks 4 and 8, respectively. In ACF, decreased LV function is accompanied by impaired sarcomeric shortening and force generation and decreased Ca2+ sensitivity, whereas, in REV, impaired LV function is accompanied by decreased Ca2+ sensitivity. Intravenous levosimendan (Levo) elicited t...
Source: AJP: Heart and Circulatory Physiology - December 1, 2014 Category: Cardiology Authors: Wilson, K., Guggilam, A., West, T. A., Zhang, X., Trask, A. J., Cismowski, M. J., de Tombe, P., Sadayappan, S., Lucchesi, P. A. Tags: MUSCLE MECHANICS AND VENTRICULAR FUNCTION Source Type: research
Affinity Proteomics for Phosphatase Interactions in Atrial Fibrillation ∗
Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice, with an estimated 30 million individuals affected worldwide (1). AF constitutes a major risk factor for stroke and heart failure, resulting in significant morbidity and mortality. Remodeling of the atria is a consequence as well as a substrate for perpetuation of AF. The remodeling process occurs at various levels, including atrial fibrosis, cardiomyocyte contractibility, and electrical coupling. During electrical remodeling, an unbalanced calcium (Ca2+) transport exposes cardiomyocytes locally to increased Ca2+ levels. Ca2+ overload i...
Source: Journal of the American College of Cardiology - January 12, 2015 Category: Cardiology Source Type: research
