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Specialty: Chemistry
Condition: Heart Attack

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Total 84 results found since Jan 2013.

Serum LRG1 as a novel biomarker for cardioembolic stroke
CONCLUSION: Serum LRG1 was a promising indicator to predict cardioembolic stroke, as well as stroke severity and the 3-month prognosis of it.PMID:33838125 | DOI:10.1016/j.cca.2021.04.002
Source: International Journal of Clinical Chemistry - April 10, 2021 Category: Chemistry Authors: Meng Zhang Yuan Wang Jing Wang Xuening Li Aijun Ma Xudong Pan Source Type: research

Inflammatory Molecular Mediators and Pathways Involved in Vascular Aging and Stroke: A Comprehensive Review
Curr Med Chem. 2021 Sep 1. doi: 10.2174/0929867328666210901122359. Online ahead of print.ABSTRACTThere is an increase in the incidence of cardiovascular diseases with aging and it is one of the leading causes of death worldwide. The main cardiovascular pathologies include atherosclerosis, stroke, myocardial infarction, hypertension and stroke. Chronic inflammation is one of the significant contributors to the age-related vascular diseases. Therefore, it is important to understand the molecular mechanisms of the persistent inflammatory conditions occurring in the blood vessels as well as the signaling pathways involved. Her...
Source: Current Medicinal Chemistry - September 7, 2021 Category: Chemistry Authors: Amro M Soliman Srijit Das Pasuk Mahakkanukrauh Source Type: research

Plasma Branched-Chain Amino Acids and Incident Cardiovascular Disease in the PREDIMED Trial Lipids, Lipoproteins, and Cardiovascular Risk Factors
CONCLUSIONS: Higher concentrations of baseline BCAAs were associated with increased risk of CVD, especially stroke, in a high cardiovascular risk population. A Mediterranean-style diet had a negligible effect on 1-year changes in BCAAs, but it may counteract the harmful effects of BCAAs on stroke.
Source: Clinical Chemistry - March 27, 2016 Category: Chemistry Authors: Ruiz-Canela, M., Toledo, E., Clish, C. B., Hruby, A., Liang, L., Salas-Salvado, J., Razquin, C., Corella, D., Estruch, R., Ros, E., Fito, M., Gomez-Gracia, E., Aros, F., Fiol, M., Lapetra, J., Serra-Majem, L., Martinez-Gonzalez, M. A., Hu, F. B. Tags: Lipids, Lipoproteins, and Cardiovascular Risk Factors Source Type: research

Comparison of Cardiac Troponins I and T Measured with High-Sensitivity Methods for Evaluation of Prognosis in Atrial Fibrillation: An ARISTOTLE Substudy Proteomics and Protein Markers
CONCLUSIONS: cTnI and cTnT concentrations are moderately correlated and measurable in plasma of most AF patients. The risk of stroke and cardiovascular events is highest when both troponins are above median concentrations. Each troponin provides comparable prognostic information when combined with clinical risk factors. ClinicalTrials.gov/NCT00412984
Source: Clinical Chemistry - January 28, 2015 Category: Chemistry Authors: Hijazi, Z., Siegbahn, A., Andersson, U., Lindahl, B., Granger, C. B., Alexander, J. H., Atar, D., Gersh, B. J., Hanna, M., Harjola, V.-P., Horowitz, J., Husted, S., Hylek, E. M., Lopes, R. D., McMurray, J. J. V., Wallentin, L. Tags: Proteomics and Protein Markers Source Type: research

Growth Differentiation Factor 15 Predicts All-Cause Morbidity and Mortality in Stable Coronary Heart Disease Proteomics and Protein Markers
CONCLUSIONS: In stable CHD, GDF-15 was independently associated with CV, non-CV, and cancer mortality, as well as with MI and stroke. When also adjusting for other prognostic biomarkers, the associations to all fatal and nonfatal events were maintained except for MI. Information on GDF-15, therefore, might be helpful when assessing the risk of adverse outcomes in patients with stable CHD. ClinicalTrials.gov Identifier: NCT00799903
Source: Clinical Chemistry - December 29, 2016 Category: Chemistry Authors: Hagstrom, E., Held, C., Stewart, R. A. H., Aylward, P. E., Budaj, A., Cannon, C. P., Koenig, W., Krug-Gourley, S., Mohler, E. R., Steg, P. G., Tarka, E., Ostlund, O., White, H. D., Siegbahn, A., Wallentin, L., on behalf of the STABILITY Investigators Tags: Proteomics and Protein Markers Source Type: research

Laboratory medicine for molecular imaging of atherosclerosis.
Abstract Atherosclerotic plaques are the main cause of life threatening clinical endpoints like myocardial infarction and stroke. To prevent these endpoints, the improved early diagnosis and treatment of vulnerable atherosclerotic vascular lesions is essential. Although originally applied for anticancer treatment, recent advances have also showed the considerable potential of nanotechnology for atherosclerosis. Otherwise, one domain of laboratory medicine is the investigation of new biomarkers. Recent research activities have identified the usability of biomarker-targeted nanoparticles for molecular imaging and ph...
Source: International Journal of Clinical Chemistry - July 5, 2014 Category: Chemistry Authors: Mangge H, Almer G, Stelzer I, Reininghaus E, Prassl R Tags: Clin Chim Acta Source Type: research

High-Sensitivity Troponin I in Stable Patients with Atherosclerotic Disease in the TRA 2{degrees}P - TIMI 50 Trial Lipids, Lipoproteins, and Cardiovascular Risk Factors
CONCLUSIONS: In stable patients with established atherosclerosis, hs-TnI concentrations effectively stratified the risk of new or recurrent cardiovascular (CV) events, in particular CV death and MI. High-risk patients with prior MI identified by increased hs-TnI had a substantial absolute improvement in net clinical outcome with vorapaxar.
Source: Clinical Chemistry - December 29, 2016 Category: Chemistry Authors: Eisen, A., Bonaca, M. P., Jarolim, P., Scirica, B. M., White, H. D., Tendera, M., Dellborg, M., Nicolau, J. C., Morais, J., Fox, K. A. A., Bohula, E. A., Murphy, S. A., Braunwald, E., Morrow, D. A. Tags: Lipids, Lipoproteins, and Cardiovascular Risk Factors Source Type: research

MicroRNAs in Venous Thrombo-Embolism.
Abstract BACKGROUND: Venous Thrombo-embolism (VTE) is the major preventable cause of death and disability worldwide. It has the third highest incidence rate of hospital death after coronary artery disease (CAD) and stroke. With the establishment of Virchow's triad stating the major factors responsible for VTE including stasis, hypercoagulability and endothelial dysfunction, the last decade reported number of studies regarding its diagnosis and prophylaxis. Till date the most commonly used clinical marker for its diagnosis is the D-dimer test, detecting endogenous fibrinolysis. This test often gives false positive ...
Source: International Journal of Clinical Chemistry - January 31, 2020 Category: Chemistry Authors: Angelina Hembrom A, Srivastava S, Garg I, Kumar B Tags: Clin Chim Acta Source Type: research

Role Of Glp-1 Analogs In The Management Of Diabetes And Its Secondary Complication
Mini Rev Med Chem. 2021 Apr 21. doi: 10.2174/1389557521666210422114909. Online ahead of print.ABSTRACTThe cardiovascular complications of type 2 diabetes mellitus (T2DM) include myocardial infarction, heart failure, peripheral vascular disease and, stroke and retinopathy, nephropathy and neuropathy are microvascular complications. While the newer therapies like glitazones or even dipeptidyl-peptidase-IV (DPP-IV) inhibitors increase the risk of therapy, the Glucagon Like Peptide-1 Receptor Agonists (GLP-1RAs), were reported as suitable alternates. The GLP-1RAs reduce the major adverse cardiovascular events (MACE), have anti...
Source: Mini Reviews in Medicinal Chemistry - April 23, 2021 Category: Chemistry Authors: Ponnurengam Malliappan Sivakumar B Premkumar Prabhawathi Veluchamy Pranav Kumar Prabhakar Source Type: research