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A Retrospective Population-Based Survival Study of Idiopathic Pulmonary Arterial Hypertension in Korea
CONCLUSION: The 10-year SR of IPAH was 57% in Korea. The HR for IPAH was significantly high in patients with older age and other risk factors.PMID:35289139 | PMC:PMC8921213 | DOI:10.3346/jkms.2022.37.e80
Source: Journal of Korean Medical Science - March 15, 2022 Category: Biomedical Science Authors: Shin Yi Jang Eun Kyoung Kim June Huh Jinyoung Song I-Seok Kang Seung Woo Park Duk-Kyung Kim Sung-A Chang Source Type: research

Comparison of the effects on cardiovascular events between use of metformin and dipeptidyl peptidase-4 inhibitors as the first-line hypoglycaemic agents in Japanese patients with type 2 diabetes mellitus: a claims database analysis
Conclusions Patients who received metformin as first-line therapy may have reduced cardiovascular events than those receiving DPP-4i. This study conforms to previous Japanese database studies, despite the consideration of its limitation being an observational design.
Source: BMJ Open - March 11, 2022 Category: General Medicine Authors: Nishimura, R., Takeshima, T., Iwasaki, K., Aoi, S. Tags: Open access, Diabetes and Endocrinology Source Type: research

Myocardial Infarction, Stroke, and All-Cause Mortality According to Low-Density Lipoprotein Cholesterol Level in the Elderly, a Nationwide Study
CONCLUSION: Among the elderly, lower LDL-C was associated with decreased risks of MI and stroke. Lower LDL-C achieved by statins in the elderly was associated with a decreased risk of all-cause death during follow-up, suggesting that LDL-C paradox for the premature death risk in the elderly should not be applied to statin users. Intensive statin therapy should not be hesitated for older adults with cardiovascular risk factors including diabetes.PMID:35255552 | DOI:10.4093/dmj.2021.0225
Source: Diabetes and Metabolism Journal - March 7, 2022 Category: Endocrinology Authors: You-Bin Lee Minji Koo Eunjin Noh Soon Young Hwang Jung A Kim Eun Roh So-Hyeon Hong Kyung Mook Choi Sei Hyun Baik Geum Joon Cho Hye Jin Yoo Source Type: research

Cardiovascular Benefits With Favorable Renal, Amputation and Hypoglycemic Outcomes of SGLT-2 Inhibitors in Type 2 Diabetes From the Asian Perspective: A Population-Based Cohort Study and Systematic Review
ConclusionAmong Asian patients with T2D, SGLT2is versus DPP4is showed benefits for several clinical outcomes. More research is warranted to explore the heterogeneous treatment effects of SGLT2is and DPP4is by race/ethnicity.
Source: Frontiers in Endocrinology - March 7, 2022 Category: Endocrinology Source Type: research

Comorbidities and Antithrombotic Treatment Pattern in Patients With Atrial Fibrillation
ConclusionsThe treatment pattern of antithrombotics did not change with the introduction of NOACs. However, comorbidities served as an important factor in choosing treatment regardless of NOAC entry.
Source: Frontiers in Neurology - March 4, 2022 Category: Neurology Source Type: research

Neuropsychological Outcomes in Individuals With Type 1 and Type 2 Diabetes
ConclusionMicrovascular/macrovascular complications are associated with a high risk of neuropsychological outcomes regardless of diabetes status. Therefore, preventing microvascular and macrovascular complications will likely help reduce the likelihood of neuropsychological outcomes either as the result of similar pathophysiologic processes or by preventing the direct and indirect consequences of these complications. For individuals with type 2 diabetes, risk factors beyond complications (such as obesity) likely contribute to neuropsychological outcomes.
Source: Frontiers in Endocrinology - March 4, 2022 Category: Endocrinology Source Type: research

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