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Aggressive LDL-C Lowering and the Brain: Impact on Risk for Dementia and Hemorrhagic Stroke: A Scientific Statement From the American Heart Association
The objective of this scientific statement is to evaluate contemporary evidence that either supports or refutes the conclusion that aggressive low-density lipoprotein cholesterol lowering or lipid lowering exerts toxic effects on the brain, leading to cognitive impairment or dementia or hemorrhagic stroke. The writing group used literature reviews, references to published clinical and epidemiology studies, clinical and public health guidelines, authoritative statements, and expert opinion to summarize existing evidence and to identify gaps in current knowledge. Although some retrospective, case control, and prospective lon...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 14, 2023 Category: Cardiology Authors: Larry B Goldstein Peter P Toth Jennifer L Dearborn-Tomazos Robert P Giugliano Benjamin J Hirsh Jessica M Pe ña Magdy H Selim Daniel Woo American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Cardiovascular and Source Type: research

Safeguarding Against Stroke Risk by Statins
Whereas mighty prospective randomized trials —and meta-analyses of these—rightly command the data used to drive guidelines and daily clinical practice, careful long-term follow-up of closely monitored cohorts can generate crucial discoveries not anticipated in a 5-year study. As just one example, findings from lifelong follow-up in the Ame rican Framingham studies and the Whitehall cohorts in the United Kingdom show a strong association between blood pressure in middle years and dementia in later life.
Source: Mayo Clinic Proceedings - September 1, 2023 Category: Internal Medicine Authors: Adrian J.B. Brady Tags: Editorial Source Type: research

Statins for extension of disability-free survival and primary prevention of cardiovascular events among older people: protocol for a randomised controlled trial in primary care (STAREE trial)
Introduction The world is undergoing a demographic transition to an older population. Preventive healthcare has reduced the burden of chronic illness at younger ages but there is limited evidence that these advances can improve health at older ages. Statins are one class of drug with the potential to prevent or delay the onset of several causes of incapacity in older age, particularly major cardiovascular disease (CVD). This paper presents the protocol for the STAtins in Reducing Events in the Elderly (STAREE) trial, a randomised double-blind placebo-controlled trial examining the effects of statins in community dwelling o...
Source: BMJ Open - April 3, 2023 Category: General Medicine Authors: Zoungas, S., Curtis, A., Spark, S., Wolfe, R., McNeil, J. J., Beilin, L., Chong, T. T.-J., Cloud, G., Hopper, I., Kost, A., Nelson, M., Nicholls, S. J., Reid, C. M., Ryan, J., Tonkin, A., Ward, S. A., Wierzbicki, A., On behalf of STAREE investigator group Tags: Open access, Cardiovascular medicine Source Type: research

Re: Yang et al. Statins and post-stroke dementia
Source: European Journal of Epidemiology - January 11, 2023 Category: Epidemiology Source Type: research

The Authors ’ Reply: Statins and post-stroke dementia
Source: European Journal of Epidemiology - January 11, 2023 Category: Epidemiology Source Type: research

Re: Yang et al. Statins and post-stroke dementia
Source: European Journal of Epidemiology - January 11, 2023 Category: Epidemiology Source Type: research

The Authors ’ Reply: Statins and post-stroke dementia
Source: European Journal of Epidemiology - January 11, 2023 Category: Epidemiology Source Type: research

Early statin use and cardiovascular outcomes after myocardial infarction: A population-based case-control study
CONCLUSIONS: Lack of statin therapy early after MI is associated with adverse outcomes across the spectrum of MI patients. Results underline the importance of timely statin use after MI.PMID:35803064 | DOI:10.1016/j.atherosclerosis.2022.06.1019
Source: Atherosclerosis - July 8, 2022 Category: Cardiology Authors: Ville Kyt ö Antti Saraste Aleksi Tornio Source Type: research

Statin use is associated with lower risk of dementia in stroke patients: a community-based cohort study with inverse probability weighted marginal structural model analysis
AbstractCurrent evidence is inconclusive on cognitive benefits or harms of statins among stroke patients, who have high risk of dementia. This observational cohort study investigated the association between statin use and post-stroke dementia using data from the Clinical Practice Research Datalink. Patients without prior dementia who had an incident stroke but received no statins in the preceding year were followed for up to 10  years. We used inverse probability weighted marginal structural models to estimate observational analogues of intention-to-treat (ITT, statin initiation vs. no initiation) and per-protocol (PP, su...
Source: European Journal of Epidemiology - March 19, 2022 Category: Epidemiology Source Type: research

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