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Specialty: Geriatrics
Condition: Dementia
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Total 327 results found since Jan 2013.
Diabetes and factors associated with cognitive and functional decline. The screening for CKD among older people across Europe (SCOPE) study
CONCLUSION: Decline in functional and cognitive status of community-dwelling older adults with DM was similar to participants without DM in a short period of 2 years of follow-up, though several clinical factors may increase its risk in this population.PMID:37668841 | DOI:10.1007/s40520-023-02536-2
Source: Aging Clinical and Experimental Research - September 5, 2023 Category: Geriatrics Authors: Francesc Formiga Ana Mar ía Badía-Tejero Andrea Corsonello Johan Ärnlöv Axel C Carlsson Francesco Mattace-Raso Lisanne Tap Tomasz Kostka Agnieszka Guligowska Cornel C Sieber Robert Kob Ronit Ben-Romano Ilan Yehoshua Regina Roller-Wirnsberger Gerhard H Source Type: research
Anticholinergic Burden and Cognitive Impairment in Nursing Homes: A Comparison of Four Anticholinergic Scales
ConclusionsThe cumulative effect of medications with modest antimuscarinic activity may influence the cognitive performance of NH residents. The anticholinergic burden measured with the ACB scale should help identify NH residents who may benefit from reducing the anticholinergic burden.A clear direct relationship between anticholinergic burden and cognitive impairment was found only for the ACB Scale.
Source: Drugs and Aging - August 24, 2023 Category: Geriatrics Source Type: research
Sex differences in cognitive impairment after focal ischemia in middle-aged rats and the effect of iv miR-20a-3p treatment
Neurobiol Aging. 2023 May 5;129:168-177. doi: 10.1016/j.neurobiolaging.2023.05.001. Online ahead of print.ABSTRACTStroke is a major cause of death and disability worldwide and is also a leading cause of vascular dementia and Alzheimer's disease, with older women experiencing accelerated decline. Our previous studies show that intravenous (iv) injections of miR-20a-3p, a small noncoding RNA (miRNA) delivered after stroke improves acute stroke outcomes in middle-aged male and female rats. The present study tested whether mir-20a-3p treatment would also ameliorate stroke-induced cognitive decline in the chronic phase. Acyclic...
Source: Neurobiology of Aging - June 19, 2023 Category: Geriatrics Authors: Dayalan Sampath Taylor E Branyan Kylee G Markowsky Rithvik Gunda Nadia Samiya Andre Obenaus Farida Sohrabji Source Type: research
Enlarged perivascular spaces and plasma A β42/Aβ40 ratio in older adults without dementia
Neurobiol Aging. 2023 Apr 14;128:43-48. doi: 10.1016/j.neurobiolaging.2023.04.004. Online ahead of print.ABSTRACTDilation of perivascular spaces (PVS) in the brain may indicate poor fluid drainage due to the accumulation of perivascular cell debris, waste, and proteins, including amyloid-beta (Aβ). No prior study has assessed whether plasma Aβ levels are related to PVS in older adults without dementia. Independently living older adults (N = 56, mean age = 68.2 years; Standard deviation (SD) = 6.5; 30.4% male) free of dementia or clinical stroke were recruited from the community and underwent brain MRI and venipuncture. P...
Source: Neurobiology of Aging - May 8, 2023 Category: Geriatrics Authors: Arunima Kapoor Aim ée Gaubert Belinda Yew Jung Yun Jang Shubir Dutt Yanrong Li John Paul M Alitin Amy Nguyen Jean K Ho Anna E Blanken Isabel J Sible Anisa Marshall Fatemah Shenasa Kathleen E Rodgers Alessandra C Martini Elizabeth Head Daniel A Nation Source Type: research
Inflammatory biomarkers and MRI visible perivascular spaces: The Framingham Heart Study
Neurobiol Aging. 2023 Mar 6;127:12-22. doi: 10.1016/j.neurobiolaging.2023.03.001. Online ahead of print.ABSTRACTWe studied the association between inflammatory biomarkers and magnetic resonance imaging (MRI) visible perivascular spaces (PVS) in Framingham Heart Study participants free of stroke and dementia. PVS in the basal ganglia (BG) and centrum semiovale (CSO) were rated with validated methods and categorized based on counts. A mixed score of high PVS burden in neither, one or both regions was also evaluated. We related biomarkers representing various inflammatory mechanisms to PVS burden using multivariable ordinal l...
Source: Neurobiology of Aging - April 5, 2023 Category: Geriatrics Authors: Oluchi Ekenze Adlin Pinheiro Serkalem Demissie Andreas Charidimou Alexa S Beiser Ramachandran S Vasan Emelia J Benjamin Charles DeCarli Sudha Seshadri Jose R Romero Source Type: research
A Psychological Intervention Program for Patients with Cerebral Infarction
Conclusion: Psychological intervention can be used as an adjunct therapy in the treatment and nursing of patients with cerebral infarction.Dement Geriatr Cogn Disord
Source: Dementia and Geriatric Cognitive Disorders - March 31, 2023 Category: Geriatrics Source Type: research
Supervised, Self-Administered Tablet-Based Cognitive Assessment in Neurodegenerative Disorders and Stroke
Conclusions: This tablet-based application was found to be widely acceptable to participants. This study supports the validity of these tablet-based assessments in the differentiation of healthy controls from patients with neurocognitive deficits in a variety of cognitive domains and across multiple neurological disease etiologies.Dement Geriatr Cogn Disord
Source: Dementia and Geriatric Cognitive Disorders - March 30, 2023 Category: Geriatrics Source Type: research
Associations of WWC1 variants with Alzheimer's disease and vascular dementia among rural older adults in China: A population-based study
Neurobiol Aging. 2023 Jan 8:S0197-4580(23)00003-9. doi: 10.1016/j.neurobiolaging.2023.01.003. Online ahead of print.ABSTRACTWe sought to examine the associations of common WWC1 variants with Alzheimer's disease (AD) and vascular dementia (VaD) among rural-dwelling older adults in China. This population-based study used data from the baseline assessments (March -September 2018) of MIND-China. AD and VaD were diagnosed following the international criteria. Of the 5455 participants (age≥60 years, 57.27% women), 182 were diagnosed with AD and 88 with VaD. Logistic regression analysis suggested that WWC1 rs17070145 C allele (...
Source: Neurobiology of Aging - January 20, 2023 Category: Geriatrics Authors: Chaoqun Wang Xiaolei Han Yi Dong Cuicui Liu Xiaojie Wang Tingting Hou Qihua Tan Yongxiang Wang Yifeng Du Chengxuan Qiu Source Type: research
Subjective Memory Complaints and Their Relationship with the Objective Cognitive Performance of Stroke Patients
Conclusion: Changes in SMCQ scores of stroke patients were inconsistent and varied when compared to changes in MMSE and MBI scores, indicating that it is not a reliable metric on its own. SMCs have a clinical relationship with OCP and significant emotional and motivational effects. In clinical practice, it is important to understand and consider SMCs after stroke.Dement Geriatr Cogn Disord
Source: Dementia and Geriatric Cognitive Disorders - January 19, 2023 Category: Geriatrics Source Type: research
