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Magnetic Resonance Imaging Findings of the Lower Limb Muscles in Anti-Mitochondrial M2 Antibody-Positive Myositis
Group of disorders characterized by myositis symptoms, including progressive muscle weakness and muscle inflammation in a setting of autoimmune abnormalities are collectively known as autoimmune myositis (AIM) or idiopathic inflammatory myopathy [1,2], including dermatomyositis (DM), anti-synthetase syndrome (ASS), immune-mediated necrotizing myopathy (IMNM), inclusion body myositis (IBM) [3,4] and other less well-characterized conditions.
Source: Neuromuscular Disorders - July 25, 2023 Category: Neurology Authors: Hirotaka Nomiya, Tadanori Hamano, Naoko Takaku, Hirohito Sasaki, Kojiro Usui, Sayaka Sanada, Tomohisa Yamaguchi, Yuki Kitazaki, Yoshinori Endo, Tomoko Kamisawa, Soichi Enomoto, Norimichi Shirahuzi, Akiko Matsunaga, Asako Ueno, Masamichi Ikawa, Osamu Yamam Tags: Research paper Source Type: research

A Case of Inflammatory Myopathy in Graft vs Host Disease - A Potential Role for Ibrutinib
Idiopathic inflammatory myopathies are a group of systemic autoimmune conditions with dominant manifestations on skeletal muscle and include the subgroups dermatomyositis, polymyositis, inclusion body myositis and necrotising myopathy. These subgroups share the clinical features of skeletal muscle weakness, raised serum levels of creatine kinase (CK), myopathic changes on electromyography and magnetic resonance imaging, but are distinguished by autoantibody profiles, and importantly by muscle histopathology which reflects the distinct pathogenetic mechanisms [1].
Source: Neuromuscular Disorders - July 4, 2021 Category: Neurology Authors: Michael Wilkinson, David Yeung, Vidya Limaye Tags: Case report Source Type: research

Sporadic inclusion body myositis: a rare hazardous entity with important imaging findings.
Abstract Inclusion body myositis is a rare acquired muscle disease that predominantly affects individuals older than 45 years of age and that has been classified as an idiopathic inflammatory myopathy. However, it has a distinct course being characterized by a slowly progressive weakness and resistance to immunosuppressive therapy. This diagnosis is usually based on a typical clinical presentation, elevated serum skeletal muscle enzymes, electromyographic findings and muscle biopsy. Magnetic Resonance Imaging (MRI) can aid in the diagnosis by directing muscle biopsy sites through accurate localization of muscle in...
Source: Acta Reumatologica Portuguesa - March 31, 2020 Category: Rheumatology Authors: Vieira AC, Vieira A Tags: Acta Reumatol Port Source Type: research

Muscle magnetic resonance imaging in inclusion body myositis: presentation of 16 cases
Magnetic Resonance Imaging (MRI) has been emerged as a complementary tool in diagnosis and follow up of patients with myopathy. Inclusion Body Myositis (IBM) is the most common acquired myopathy in patients older than 50 years old. It presents with a characteristic pattern of muscle affectation. Despite this, in some patients the diagnosis is not always easy or straightforward. To describe muscle MRI characteristics or a particular pattern in patients with diagnosis of IBM. Patients with diagnosis of IBM according the European Group criteria were included.
Source: Neuromuscular Disorders - September 10, 2017 Category: Neurology Authors: M. Rugiero, M. Bettini, M. Araoz, N. Genco, M. Chaves, S. Christiansen, A. Rassumoff Source Type: research

The role of magnetic resonance imaging techniques in evaluation and management of the idiopathic inflammatory myopathies
The idiopathic inflammatory myopathies (IIMs) are a group of heterogeneous systemic autoimmune conditions characterised by muscle inflammation and a host of extramuscular manifestations. The term encompasses sporadic inclusion body myositis (IBM), polymyositis (PM), juvenile dermatomyositis (JDM), adult dermatomyositis (DM), necrotising myopathy (NM) of which a subset is autoimmune (necrotising autoimmune myopathy; NAM), and overlap myositis, where the muscle disorder is associated with another connective tissue disease (usually scleroderma or mixed connective tissue disease).
Source: Seminars in Arthritis and Rheumatism - November 4, 2016 Category: Rheumatology Authors: Jessica Day, Sandy Patel, Vidya Limaye Source Type: research

Hereditary Inclusion Body Myopathy without Paget Disease and Frontotemporal Dementia Associated with Valosin-Containing Protein Mutation: A Case Report (P5.074)
CONCLUSIONS: The aforementioned VCP gene mutation is associated with variable IBMPFD phenotypes, which can differ even amongst family members. Familial IBMPFD and VCP testing should be considered in atypical sporadic IBM-like patients, whose weakness is associated with extramuscular features, and those with family history of myopathy.Disclosure: Dr. Pack has nothing to disclose. Dr. Walsh has nothing to disclose. Dr. Rakocevic has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Pack, K., Walsh, A., Rakocevic, G. Tags: Hereditary Muscle Diseases: Genetics and Phenotype Source Type: research

Muscle Magnetic Resonance Imaging in Inclusion Body Myositis: Presentation of 12 Cases (P4.089)
Conclusions: MRI pattern in IBM in this study is characterized by higher affectation of lateral and internal vastus, semimembranosus, semitendinosus and medial gastrocnemius. Preservation of Sartorius and gracillis muscles is also remarkable, as mild or no affectation of pelvic muscles. Although this pattern was described in other series it should be validated in further studies.Disclosure: Dr. Bettini has nothing to disclose. Dr. araoz has nothing to disclose. Dr. rugiero has nothing to disclose. Dr. Chaves has nothing to disclose. Dr. genco has nothing to disclose. Dr. Christiansen has nothing to disclose. Dr. rasumoff h...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Bettini, M., Araoz, M., Rugiero, M., Chaves, M., Genco, D., Christiansen, S., Rasumoff, A., Cristiano, E. Tags: Imaging Studies in Muscle Diseases and Others Source Type: research

Myositides : What is the current situation?
This article gives a review of the classification, diagnostic procedures and treatment of idiopathic inflammatory myopathies from a neurological point of view. The myositis syndromes can be subdivided into four groups, polymyositis (PM), dermatomyositis (DM), inclusion body myositis (IBM) and necrotizing myopathy (NM), which substantially differ clinically and pathophysiologically. Myositis may also occur in association with cancer or autoimmune systemic diseases (overlap syndrome). Diagnosis of inflammatory myopathies is based on clinical symptoms, determination of creatine phosphokinase and acute phase parameters in bloo...
Source: Zeitschrift fur Rheumatologie - July 18, 2015 Category: Rheumatology Authors: Rösler KM, Scheidegger O Tags: Z Rheumatol Source Type: research

Cardiac and Muscular Involvement in Idiopathic Inflammatory Myopathies: Noninvasive Diagnostic Assessment and the Role of Cardiovascular and Skeletal Magnetic Resonance Imaging.
Abstract Idiopathic inflammatory myopathies (IIMs) are rare autoimmune diseases and include dermatomyositis, polymyositis, necrotizing myopathy and inclusion body myositis; they are characterized by inflammation of skeletal muscle and other internal organs and may potentially lead to irreversible damage and death. Only a small percentage of IIM has clinically overt cardiac disease; however, heart involvement is one of the leading causes of death and therefore, early detection remains a challenge. Biochemical markers and non-invasive methods such as the electrocardiogram and echocardiography have a role in diagnosi...
Source: Inflammation and Allergy Drug Targets - May 26, 2014 Category: Allergy & Immunology Authors: Mavrogeni S, Sfikakis PP, Dimitroulas T, Kolovou G, Kitas GD Tags: Inflamm Allergy Drug Targets Source Type: research

Diagnosis, pathogenesis and treatment of myositis: recent advances
Abstract Dermatomyositis (DM), polymyositis (PM), necrotizing myopathy (NM) and inclusion body myositis (IBM) are four distinct subtypes of idiopathic inflammatory myopathies –in short myositis. Recent studies have shed some light on the unique pathogenesis of each entity. Some of the clinical features are distinct, but muscle biopsy is indispensable for making a reliable diagnosis. The use of magnetic resonance imaging of skeletal muscles and detection of myositis‐specific autoantibodies have become useful additions to our diagnostic repertoire. Only few controlled trials are available to substantiate current treatmen...
Source: Clinical and Experimental Immunology - August 27, 2013 Category: Allergy & Immunology Authors: Per‐Ole Carstens, Jens Schmidt Tags: Review Source Type: research

Diagnosis, pathogenesis and treatment of myositis: recent advances.
Abstract Dermatomyositis (DM), polymyositis (PM), necrotizing myopathy (NM) and inclusion body myositis (IBM) are four distinct subtypes of idiopathic inflammatory myopathies -in short myositis. Recent studies have shed some light on the unique pathogenesis of each entity. Some of the clinical features are distinct, but muscle biopsy is indispensable for making a reliable diagnosis. The use of magnetic resonance imaging of skeletal muscles and detection of myositis-specific autoantibodies have become useful additions to our diagnostic repertoire. Only few controlled trials are available to substantiate current tre...
Source: Clinical and Developmental Immunology - August 27, 2013 Category: Allergy & Immunology Authors: Carstens PO, Schmidt J Tags: Clin Exp Immunol Source Type: research