Psoriatic arthritis and Ankylosing Spondylitis Impact on Health-related Quality of Life and Working Life: A Comparative Population-Based Study.
CONCLUSIONS: AS and PsA were found to be associated with poor QoL and a high rate of disease-related early retirement, emphasizing the burden of such rheumatic conditions in Portugal. PMID: 32008031 [PubMed - as supplied by publisher] (Source: Acta Reumatologica Portuguesa)
Source: Acta Reumatologica Portuguesa - December 27, 2019 Category: Rheumatology Authors: Rodrigues J, Rodrigues AM, Dias SS, Sousa RD, Branco JC, Canhão H Tags: Acta Reumatol Port Source Type: research

Biologic therapy use and pregnancy outcomes in women with immune-mediated inflammatory rheumatic diseases.
CONCLUSIONS: In half cases, it was decided to stop biologic therapy in the family planning period. Using biologic disease-modifying anti-rheumatic drugs before and/or during pregnancy doesn't seem to affect the overall maternal and fetal outcomes. Pregnancy planning and treatment options should be discussed and a shared decision should be established between physician and patient. PMID: 32008032 [PubMed - as supplied by publisher] (Source: Acta Reumatologica Portuguesa)
Source: Acta Reumatologica Portuguesa - December 26, 2019 Category: Rheumatology Authors: Brites L, Madeira N, Rodrigues J, Marona J, Martins N, Águeda A, Freitas R, Neto A, Capela S, Sequeira G, Ganhão S, Duarte C, Santiago M, Santos MJ Tags: Acta Reumatol Port Source Type: research

How challenging can Neuropsychiatric Systemic Lupus Erythematous be? - Experience from a tertiary care centre.
We report four cases of Neuropsychiatric Systemic Lupus Erythematous, illustrating how challenging it can be to diagnose and treat these patients. PMID: 32008034 [PubMed - as supplied by publisher] (Source: Acta Reumatologica Portuguesa)
Source: Acta Reumatologica Portuguesa - December 3, 2019 Category: Rheumatology Authors: Duarte AC, Barata Silvério T, Sousa S, Ribeiro AC, Gonçalves P, Cordeiro A Tags: Acta Reumatol Port Source Type: research

Efficacy, immunogenicity and cost analysis of a systematic switch from originator infliximab to biosimilar CT-P13 of all patients with inflammatory arthritis from a single center.
ca JE Abstract Biosimilar drugs are intended to be as effective as the originator product but with a lower cost to healthcare systems. In our center we promoted a switch from originator infliximab (IFXor) to biosimilar infliximab (CT-P13). We analyzed efficacy, safety, immunogenicity and cost savings of switching. Eligible patients were adults with the diagnosis of rheumatoid arthritis (RA), spondyloarthritis (SpA) and psoriatic arthritis (PsA) on therapy with IFXor for at least 6 months and with stable disease activity. Efficacy was measured considering change from baseline in Disease Activity Score in 28 joints ...
Source: Acta Reumatologica Portuguesa - November 22, 2019 Category: Rheumatology Authors: Valido A, Silva-Dinis J, Saavedra MJ, Iria I, Gonçalves J, Lopes JP, da Fonseca JE Tags: Acta Reumatol Port Source Type: research

Fall determinants in the adult Portuguese: do chronic conditions change the risk of falling?
CONCLUSIONS: Our results show a perspective of the determinants of falls in the Portuguese population, allowing us to know that women and elders are at greater risk. We have showed that some chronic diseases are associated with falls, in particular musculoskeletal diseases and mental diseases. Implementing specific and adapted prevention strategies might reduce the number and complications of falls ultimately improving Portuguese overall health. PMID: 31754087 [PubMed - as supplied by publisher] (Source: Acta Reumatologica Portuguesa)
Source: Acta Reumatologica Portuguesa - November 19, 2019 Category: Rheumatology Authors: Marques AJ, Rodrigues A, Dias S, Canhão H, Branco J, Vaz C Tags: Acta Reumatol Port Source Type: research

Intensity of Inflammation as the most important predictor of myocardial involvement in JIA, A 3D Echocardiographic study.
Abstract INTRODUCTION: Myocardial dysfunction is an important complication in the context of juvenile idiopathic arthritis (JIA). Several mechanisms might be involved in the induction of myocardial injury in such a disabling disease. Among several factors involved, myocardial inflammation and cardiotoxic drugs were thought to be the most incriminated factors. The aim of this paper was to determine the most important factors that implicated myocardial injury in JIA and to weigh whether the severity of inflammation varies significantly among the several subtypes or not. METHODS: Sixty JIA patients as well as si...
Source: Acta Reumatologica Portuguesa - November 4, 2019 Category: Rheumatology Authors: AbdelMassih AF, Salem A, Arabi S, Malak L, Marzouk H Tags: Acta Reumatol Port Source Type: research

Autohemotherapy with ozone as a possible effective treatment for Fibromyalgia.
CONCLUSIONS: The autohemotherapy with ozone in patients with FM showed an important decline of tender points and FIQ score, as well as a decrease of oxidative stress levels. This treatment allows patients to face life with greater vitality and less drug use, diminishing harmful side effects. Further investigation should be carried out, including groups with more patients and clinical trials, to elucidate the effect of ozone therapy in patients suffering from FM. PMID: 31575841 [PubMed - as supplied by publisher] (Source: Acta Reumatologica Portuguesa)
Source: Acta Reumatologica Portuguesa - September 29, 2019 Category: Rheumatology Authors: Moreno-Fernández A, Macías-García L, Valverde-Moreno R, Ortiz T, Fernández-Rodríguez A, Moliní-Estrada A, De-Miguel M Tags: Acta Reumatol Port Source Type: research

Tongue ischemia - an unusual presentation of Giant Cell Arteritis.
In conclusion, the clinical suspicion of GCA is fundamental for an early diagnosis. The authors consider that ergotamine might have triggered tongue ischemia in this case. PMID: 31575844 [PubMed - as supplied by publisher] (Source: Acta Reumatologica Portuguesa)
Source: Acta Reumatologica Portuguesa - September 29, 2019 Category: Rheumatology Authors: Lima FB, Costa P, Carreiro FT, Amaral J, Rocha M, Dias L Tags: Acta Reumatol Port Source Type: research

First steps to understand productivity loss in Portuguese patients with rheumatoid arthritis.
nto P Abstract Rheumatoid Arthritis (RA), in consequence of joint inflammation and damage, is known to lead to productivity loss. Developments during the 21st century, such as biologic treatments, allowed remission/low disease activity to be achieved in more RA patients. Despite this, evidence is equivocal concerning work outcomes improvement. Our goal was to evaluate work status and productivity in a Portuguese population with RA from 3 Rheumatology Departments through the questionnaire Work Productivity and Activity Impairment General Health (WPAI). PMID: 31575842 [PubMed - as supplied by publisher] (Source...
Source: Acta Reumatologica Portuguesa - September 24, 2019 Category: Rheumatology Authors: Guerra MG, Vieria R, Ganhão S, Rodrigues J, Fonseca D, Videira T, Bernardes M, Pinto P Tags: Acta Reumatol Port Source Type: research

Endothelin-1 serum levels in women with Rheumatoid Arthritis.
;lez-Gay MA, Ortego-Centeno N Abstract OBJECTIVE: The purpose of this study was to evaluate serum Endothelin-1(ET-1) levels in women Rheumatoid Arthritis (RA) patients compared with healthy controls, examine possible associations between ET-1 with different characteristic of the disease and investigate possible associations between ET-1 with surrogate markers of cardiovascular disease (CVD). METHODS: This cross-sectional study was performed in Vega-Baja Hospital, Orihuela (Spain) from November 2016 to May 2018. Sixty-three women with RA and sixty-five age and sex healthy controls were included in this study. ...
Source: Acta Reumatologica Portuguesa - September 24, 2019 Category: Rheumatology Authors: Alvarez-Cienfuegos A, Cantero-Nieto L, García-Gómez JA, Ríos-Fernández R, Martin J, González-Gay MA, Ortego-Centeno N Tags: Acta Reumatol Port Source Type: research

Bilateral vertebral artery occlusion without stroke secondary to giant cell arteritis.
We report a case of an 84-year-old male patient with anterior ischaemic optic neuropathy secondary to giant cell arteritis, with bilateral occlusion of the vertebral arteries manifested with nonspecific neurological signs, detected during the ultrasound scan of the cervical arteries. The rarity of this case lies in the reasonably good outcome at the three-month and six-month follow-up and the absence of temporal artery involvement, despite the severe vertebral artery affection with bilateral occlusion. PMID: 31575840 [PubMed - as supplied by publisher] (Source: Acta Reumatologica Portuguesa)
Source: Acta Reumatologica Portuguesa - September 23, 2019 Category: Rheumatology Authors: Bajko Z, Filep RC, Maier S, Motataianu A, Andone S, Balasa R Tags: Acta Reumatol Port Source Type: research

Rheuma SPACE - Standard Practice Aiming Clinical Excellence: description of the methodological approach.
This article details the methodology that was applied. METHODOLOGY: This was a single country, three-phase project, each phase comprising multiple steps. The first step defined quality indicators and the excellence quality model to be used. It involved a literature search for international benchmarking of quality of care initiatives and indicators, followed by a pre-selection of an initial set of indicators. The set of indicators was latter on narrowed after an online Delphi round with all Portuguese rheumatologists and two consensus meetings involving the study task force. A set of 26 quality indicators was defined, ...
Source: Acta Reumatologica Portuguesa - September 8, 2019 Category: Rheumatology Authors: Macieira C, Cunha-Miranda L, Nero P, Laires P, Bogas M, Farinha S, Freitas I, Lucas P, Sousa J, Narciso L, Mateus E, Canas da Silva J, Fonseca JE, Study Group RS Tags: Acta Reumatol Port Source Type: research

Pleuroparenchymal Fibroelastosis in association with Connective Tissue Disease: a new interstitial pneumonia to be aware of.
ais A Abstract Pleuroparenchymal fibroelastosis (PPFE) is a rare and recently described interstitial pneumonia. It consists of progressive fibrosis involving the pleura and subpleural lung parenchyma, predominantly in the upper lobes, with defined and reproducible clinical, radiological and histopathological criteria. No effective treatment has yet been shown to modify the natural course of the disease, which vary greatly in the literature. Several conditions have been associated with PPFE, including connective tissue diseases (CTD). The authors present two cases of female patients with a CTD (rheumatoid arthritis...
Source: Acta Reumatologica Portuguesa - August 7, 2019 Category: Rheumatology Authors: Carvalho J, Vieira AC, Ferra J, Novais E Bastos H, Caetano Mota P, Melo N, Guimarães S, Pereira JM, Bernardes M, Morais A Tags: Acta Reumatol Port Source Type: research

Non-Pharmacological and Non-Surgical Interventions for Knee Osteoarthritis: A Systematic Review and Meta-Analysis.
CONCLUSIONS: Exercise is the best intervention for knee OA patients. Pulsed Electromagnetic Fields and Moxibustion showed to be the most promising interventions from the others options available. PMID: 31356585 [PubMed - as supplied by publisher] (Source: Acta Reumatologica Portuguesa)
Source: Acta Reumatologica Portuguesa - July 29, 2019 Category: Rheumatology Authors: Ferreira RM, Torres RT, Duarte JA, Gonçalves RS Tags: Acta Reumatol Port Source Type: research

Outcomes of rheumatic patients referred from Portuguese speaking African countries for medical evaluation in Portugal.
Abstract Bureaucratic, social and economic barriers may influence several clinical aspects of rheumatic diseases in patients from Portuguese speaking African countries (PALOP) displaced for medical care in Portugal. Despite the apparent advantages of dislocating patients to a more resourceful country, these patients present with long-lasting and severe rheumatic diseases with chronic damage, due to lack of precise diagnosis, ineffective referrals, lack of appropriate treatment and concomitant infectious comorbidities that may jeopardize the outcomes of these strategies. PMID: 31356584 [PubMed - as supplied by...
Source: Acta Reumatologica Portuguesa - July 22, 2019 Category: Rheumatology Authors: Teixeira V, Barreira S, Valido A, Macieira C, Fonseca JE Tags: Acta Reumatol Port Source Type: research

Assessment of the vaccination status in rheumatic disease patients treated with disease-modifying antirheumatic drugs.
Abstract Patients with rheumatic diseases are at a higher risk for infections associated to the underlying pathology and immunosuppressive therapy. This fact leads to an increased morbidity and/or mortality. Effective vaccination is essential for the prevention of a significant number of these infections, namely influenza and pneumococcal vaccination. In our cohort, and despite current recommendations, vaccination rates are still low among patients with autoimune diseases, which is in agreement with the available literature. A greater effort from all physicians is required to improve these results and to make the ...
Source: Acta Reumatologica Portuguesa - July 11, 2019 Category: Rheumatology Authors: Brites L, Costa F, Freitas JP, Silva S, Duarte C, Santiago M Tags: Acta Reumatol Port Source Type: research

Hepatic vasculitis mimicking multiple liver abscesses in Cogan's Syndrome.
We report a rare case of a patient with typical Cogan syndrome who developed hepatic vasculitis with hepatic infarction mimicking multiple liver abscesses. Diagnosis of CS is often missed or delayed due to its rarity, the nonspecific clinical signs at onset, and the lack of a confirmatory diagnostic test. Rheumatologists should be aware of this entity and its possible systemic manifestations. The present case is unique because of the severity and involved area of the vasculitis. PMID: 31308353 [PubMed - as supplied by publisher] (Source: Acta Reumatologica Portuguesa)
Source: Acta Reumatologica Portuguesa - July 8, 2019 Category: Rheumatology Authors: Dinis de Freitas J, Costa F, Rovisco J Tags: Acta Reumatol Port Source Type: research

Dermatoscopic and Mucoscopic Features of Lesions in Patients with Behcet's Disease.
CONCLUSION: It seems that these findings have no specific clues for the diagnosis of BD, but our study is the first study in this field and the findings may give way to further investigations. PMID: 31300633 [PubMed - as supplied by publisher] (Source: Acta Reumatologica Portuguesa)
Source: Acta Reumatologica Portuguesa - July 1, 2019 Category: Rheumatology Authors: Ghodsi SZ, Bahrololoumi Bafruee N, Chams Davatchi C, Rosendahl C, Akay BN, Davatchi F, Chams H, Shahram F, Nadji A, Akhlaghi M, Faezi T, Kavosi H Tags: Acta Reumatol Port Source Type: research

The very early inflammatory triquetral lesion by MRI - is this the first sign in Rheumatoid Arthritis?
CONCLUSION: Synovitis and triquetral synovitis were the most prevalent lesion in three-studied phases. This could suggest the triquetrum as the first morphological site to be affected by RA; so it's assessment should be considered in the RA evaluation when it´s clinically suspected. PMID: 31300634 [PubMed - as supplied by publisher] (Source: Acta Reumatologica Portuguesa)
Source: Acta Reumatologica Portuguesa - July 1, 2019 Category: Rheumatology Authors: Larios-Forte MDC, García-Coronado JM, Skinner-Taylor CM, Esquivel-Valerio JA, Vega-Morales D, Vilchez-Cavazos F, Quiroga-Garza A, Elizondo-Omaña RE Tags: Acta Reumatol Port Source Type: research

How to diagnose lupus enteritis early? Lessons learned from a multicenter case series.
We report seven cases of LE (female: 100%; age range: 16-55 years). All presented with acute onset abdominal pain, nausea and vomiting at the emergency room. Two patients had lupus enteritis as inaugural manifestation of SLE. Of the remaining five, one presented at the previous visit to the lupus clinic with clinically active disease and two had serologically active/ clinically inactive SLE. High anti-dsDNA antibodies and low serum complement were universally present at time of the LE event. Abdominal ultrasound was the first imaging exam to be performed in the emergency room. In all cases it showed bowel wall thickening, ...
Source: Acta Reumatologica Portuguesa - June 2, 2019 Category: Rheumatology Authors: Luís M, Brites AL, Duarte AC, Teixeira V, Freitas R, Oliveira-Ramos F, Macieira C, Santos MJ, Inês L Tags: Acta Reumatol Port Source Type: research

Antifibrotics in interstitial lung disease related to connective tissue diseases - a paradigm shift in treatment and outcome.
We report 3 cases of patients with different CTDs, with predominantly fibrotic changes in high resolution computed tomography that progressed despite immunosuppression, and who have attained disease stability after introduction of antifibrotic drugs. PMID: 31280278 [PubMed - as supplied by publisher] (Source: Acta Reumatologica Portuguesa)
Source: Acta Reumatologica Portuguesa - May 18, 2019 Category: Rheumatology Authors: Duarte AC, Vinagre F, Soares J, Cordeiro A Tags: Acta Reumatol Port Source Type: research

Low persistence with oral biphosphonate treatment in postmenopausal osteoporosis.
CONCLUSIONS: Results indicate a low level of persistence with OBP. Barriers and reasons leading to discontinuation of anti-PMO therapies should be proactively addressed to promote persistence and improve fracture protection. PMID: 31280276 [PubMed - as supplied by publisher] (Source: Acta Reumatologica Portuguesa)
Source: Acta Reumatologica Portuguesa - May 16, 2019 Category: Rheumatology Authors: Torre C, Guerreiro J, Mendes Z, Miranda A, Bragança F, Cristino J, Canhão H, Branco JC Tags: Acta Reumatol Port Source Type: research

The relationship between anthropometric status and rheumatoid arthritis. Exploring the role of nesfatin and asymmetric dimethylarginine.
CONCLUSIONS: Weight, BMI, and WC were correlated with the activity of RA and the concentrations of CRP and ESR went up in tandem with BMI. In addition, ADMA, but not nesfatin-1, was associated with BMI and disease activity in RA patients. PMID: 31280277 [PubMed - as supplied by publisher] (Source: Acta Reumatologica Portuguesa)
Source: Acta Reumatologica Portuguesa - May 15, 2019 Category: Rheumatology Authors: Naghashian F, Hosseinzadeh-Attar MJ, Akhlaghi M, Yekaninejad MS, Aryaeian N, Derakhshanian H Tags: Acta Reumatol Port Source Type: research

Chondrosarcoma as inaugural manifestation of monostotic Paget's disease of Bone.
We describe a unique case of Paget's chondrosarcoma of the pelvis in an elderly female patient, with no previous established diagnosis of osteitis deformans. We emphasize clinical and radiologic aspects that should raise suspicion of malignant transformation, revealing good correlation with the final histopathological diagnosis. PMID: 31266050 [PubMed - as supplied by publisher] (Source: Acta Reumatologica Portuguesa)
Source: Acta Reumatologica Portuguesa - May 15, 2019 Category: Rheumatology Authors: Ferreira RM, Vieira L, Pimenta S, Pinto J, Costa L Tags: Acta Reumatol Port Source Type: research

Tocilizumab and rituximab have similar effectiveness and are both superior to a second tumour necrosis factor inhibitor in rheumatoid arthritis patients who discontinued a first TNF inhibitor.
, Santos MJ Abstract OBJECTIVES: To compare the effectiveness of a 2nd TNF inhibitor (TNFi), Tocilizumab (TCZ) and Rituximab (RTX), measured by drug retention and by response rates, in RA patients after discontinuing a first-line TNFi and to clarify the reasons and predictors for discontinuation of a second-line biologic. MATERIAL AND METHODS: Non-interventional prospective study of RA patients exposed to a 2nd TNFi, TCZ or RTX after previous TNFi discontinuation using real-world data from Reuma.pt database. Drug retention was estimated using Kaplan-Meier analysis and Cox models. Crude and LUNDEX adjusted res...
Source: Acta Reumatologica Portuguesa - May 15, 2019 Category: Rheumatology Authors: Santos-Faria D, Tavares-Costa J, Eusébio M, Leite Silva J, Ramos Rodrigues J, Sousa-Neves J, Duarte AC, Lopes C, Valido A, Dinis J, Freitas J, Santiago M, Ferreira R, Ganhão S, Miranda L, Peixoto D, Teixeira F, Alcino S, Afonso C, Santos MJ Tags: Acta Reumatol Port Source Type: research

Intraarticular injection of platelet-rich plasma in knee osteoarthritis: single versus triple application approach. Pilot study.
CONCLUSION: The triple infiltration of PRP in patients with mild knee osteoarthritis is clinically more effective than the single application at 48 weeks of follow-up. PMID: 31243258 [PubMed - as supplied by publisher] (Source: Acta Reumatologica Portuguesa)
Source: Acta Reumatologica Portuguesa - April 23, 2019 Category: Rheumatology Authors: Simental-Mendía M, Acosta-Olivo CA, Hernández-Rodríguez AN, Santos-Santos OR, de la Garza-Castro S, Peña-Martínez VM, Vilchez-Cavazos F Tags: Acta Reumatol Port Source Type: research

Positive affect as a predictor of adherence in patients with Rheumatoid Arthritis.
Abstract The study was conducted in order to investigate adherence in patients with Rheumatoid arthritis (RA), correlating it with other variables such as affect and self-esteem. Seventy-eight patients with RA between 20 and 81 years of age were evaluated. Patients were assessed for Medical Outcomes Study (MOS) Measures of Patient Adherence, Rosenberg self-esteem scale and Short Portuguese version of the Positive and Negative Affect Schedule (PANAS). Pearson's correlation coefficient was used to assess the correlation between the therapeutic compliance and age, disease activity, disability, GPA, self-esteem, affec...
Source: Acta Reumatologica Portuguesa - April 22, 2019 Category: Rheumatology Authors: Rodrigues JR, Faria DS, Neves JS, Silva J, Peixoto D, Alcino S, Afonso MC, Teixeira F, Afonso RM, Pereira H, Azevedo S, Costa JT Tags: Acta Reumatol Port Source Type: research

Tumoral calcinosis in a rheumatoid arthritis patient - a rare case report.
PMID: 31235680 [PubMed - as supplied by publisher] (Source: Acta Reumatologica Portuguesa)
Source: Acta Reumatologica Portuguesa - April 22, 2019 Category: Rheumatology Authors: Martins P, Marques D, Janeiro J, Romeu JC, Ponte C Tags: Acta Reumatol Port Source Type: research

The geyser sign: an unusual presentation of a rotator cuff tear.
PMID: 31235681 [PubMed - as supplied by publisher] (Source: Acta Reumatologica Portuguesa)
Source: Acta Reumatologica Portuguesa - March 30, 2019 Category: Rheumatology Authors: Martins P, Teixeira V, Saraiva F, Ponte C Tags: Acta Reumatol Port Source Type: research

Tocilizumab in refractory juvenile idiopathic arthritis with associated uveitis: a case report.
This report supports Tocilizumab as a useful therapeutic option for JIA-associated uveitis. PMID: 31230059 [PubMed - as supplied by publisher] (Source: Acta Reumatologica Portuguesa)
Source: Acta Reumatologica Portuguesa - February 7, 2019 Category: Rheumatology Authors: Sousa-Neves F, Braga J, Teixeira S, Barge S, Fonseca S, Meira D, Rodrigues L, Varandas R Tags: Acta Reumatol Port Source Type: research

Telerheumatology - breaking barriers to access care in Rheumatology.
ira C Abstract Telehealth applied to rheumatology, known as telerheumatology, is an emerging trend in healthcare in many countries. It constitutes a promising approach with the potential to anticipate the contact of patients from remote areas with Rheumatologists, leading to earlier diagnosis and treatment, and thus probably to better long-term outcomes. Telerheumatology under the scope of International collaborations may also improve the access of the PALOP population to Rheumatology care, resulting in proper shared decisions for patient's evacuation, preventing family separation and reducing the costs associated...
Source: Acta Reumatologica Portuguesa - October 1, 2018 Category: Rheumatology Authors: Teixeira V, Cordeiro I, Gonçalves MJ, Fonseca JE, Macieira C Tags: Acta Reumatol Port Source Type: research

Predictors of walking capacity in obese adults with knee osteoarthritis.
ira P Abstract INTRODUCTION: Knee osteoarthritis(KOA) has a considerable prevalence in obese individuals and recommendations of weight loss for KOA management are gaining greater importance. Exercise is recommended to interrupt the cycle obesity-KOA-pain-inactivity, where walking is the most common exercise pattern recommended for obese individuals who initiate a weight loss exercise program. Thus this study aimed to analyse the factors which can affect the walking capacity in obese adults with symptomatic KOA. METHODS: 48 obese adults (age=55±7years; BMI=35±5 Kg/m2) with clinical and radiologic...
Source: Acta Reumatologica Portuguesa - October 1, 2018 Category: Rheumatology Authors: Yázigi F, Espanha M, Marques A, Teles J, Teixeira P Tags: Acta Reumatol Port Source Type: research

Articular cartilage of knee and first MTP joint are the preferred sites to find double contour sign as an evidence of urate crystal deposition in asymptomatic hyperuricemic individuals.
Abstract BACKGROUND/OBJECTIVE: A cross-sectional study to determine the preferred sites of urate crystal deposition in asymptomatic hyperuricemic individuals by ultrasound. METHODS: In two years period twenty four asymptomatic hyperuricemic individuals (serum uric acid ≥7mg/dl) and fifty controls (serum uric acid
Source: Acta Reumatologica Portuguesa - October 1, 2018 Category: Rheumatology Authors: Bhadu D, Das SK, Wakhlu A, Dhakad U Tags: Acta Reumatol Port Source Type: research

Th17 pathway genes polymorphisms in Algerian patients with systemic sclerosis.
CONCLUSION: The study revealed that IL-17F and IL-21 genes were associated with systemic sclerosis (SSc) susceptibility and that IL-17A, IL-17F, IL-21 and IL-23R genes influence the clinical and immunological features, which suggest the implication of TH17 cells in SSc pathogenesis. PMID: 30641535 [PubMed - in process] (Source: Acta Reumatologica Portuguesa)
Source: Acta Reumatologica Portuguesa - October 1, 2018 Category: Rheumatology Authors: Mellal Y, Allam I, Tahiat A, Abessemed A, Nebbab R, Ladjouze A, Djidjik R Tags: Acta Reumatol Port Source Type: research

SLICC classification criteria for juvenile systemic lupus erythematosus: a cross sectional study.
CONCLUSION: our results were similar to previous studies with both children and adults, and classification criteria should be used with caution. The SLICC criteria showed high sensitivity and specificity for the classification of jSLE. PMID: 30641536 [PubMed - in process] (Source: Acta Reumatologica Portuguesa)
Source: Acta Reumatologica Portuguesa - October 1, 2018 Category: Rheumatology Authors: Osaku FM, Fraga MM, Aires PP, Caparroz AA, Len CA, Terreri MT Tags: Acta Reumatol Port Source Type: research

The association between clinically suspect arthralgia and adipokines in obese patients.
CONCLUSION: Visfatin and chemerin correlated with inflammation and may be useful indicators of undifferentiated inflammatory arthritis in obese patients with CSA. PMID: 30641537 [PubMed - in process] (Source: Acta Reumatologica Portuguesa)
Source: Acta Reumatologica Portuguesa - October 1, 2018 Category: Rheumatology Authors: Kose R, Sargin G, Senturk T, Cildag S, Unubol M, Abas Bİ, Yenisey C Tags: Acta Reumatol Port Source Type: research

Determinants of non-nociceptive pain in Rheumatoid Arthritis.
CONCLUSION: NP was associated with disease activity/functional scores but not with objective inflammatory measures. Greater structural damage, increased disease duration and ACPA positivity did not seem to increase the odds of NP. Possible association of NP and underlying csDMARD treatment was uncovered. PMID: 30641538 [PubMed - in process] (Source: Acta Reumatologica Portuguesa)
Source: Acta Reumatologica Portuguesa - October 1, 2018 Category: Rheumatology Authors: Martins Rocha T, Pimenta S, Bernardo A, Bernardes M, Barbosa M, Lucas R, Vollert J, Costa L, Maier C Tags: Acta Reumatol Port Source Type: research

Neuromuscular manifestations of primary biliary cholangitis: two case reports and literature review.
We report two cases of patients with the diagnosis of PBC with neurologic complications: one case with asymptomatic PBC and myopathy and another one with demyelinating neuropathy. Neurologic diseases in patients with PBC have been described mainly as case reports. The co-occurrence of both entities suggests the possible existence of a common pathogenic mechanism but the real etiopathogeny is still unknown. PMID: 30641539 [PubMed - in process] (Source: Acta Reumatologica Portuguesa)
Source: Acta Reumatologica Portuguesa - October 1, 2018 Category: Rheumatology Authors: Brites L, Ribeiro J, Luis M, Santiago M, Negrão L, Duarte C Tags: Acta Reumatol Port Source Type: research

Silent acute myocarditis in eosinophilic granulomatosis with polyangiitis.
We present a case of this condition in a 65-year-old woman with a past medical history of rhinosinusitis and recent episodes of asthma, that developed palpable purpura, sensory deficiency and excruciating pain mainly in the lower limbs. A significant hypereosinophilia and elevated troponin level were found, although she had not cardiac symptomatology. Cardiovascular magnetic resonance revealed late gadolinium enhancement and a severe reduction of the left ventricular ejection fraction. Mononeuritis multiplex was documented and diagnosis was confirmed by biopsy. Complementary cardiac investigation is mandatory in any patien...
Source: Acta Reumatologica Portuguesa - October 1, 2018 Category: Rheumatology Authors: Ferreira RM, Madureira P, Pinho T, Martins E, Pimenta S, Costa L Tags: Acta Reumatol Port Source Type: research

Mickey mouse sign - a rare and specific finding of Paget's disease of bone.
PMID: 30641541 [PubMed - in process] (Source: Acta Reumatologica Portuguesa)
Source: Acta Reumatologica Portuguesa - October 1, 2018 Category: Rheumatology Authors: Guerra M, Fonseca D, Videira T, Vieira R, Aleixo JA, Pinto P Tags: Acta Reumatol Port Source Type: research

Systemic sclerosis and myositis as a paraneoplastic syndrome secondary to multiple myeloma.
We present a case of paraneoplastic systemic sclerosis (SSc) and myositis associated to a multiple myeloma (MM) in a 52-year-old Caucasian man. After MM treatment, skin and muscle changes improved, with no further relapses. Although rare, "scleroderma-like" or myositis lesions may be associated with MM. However, to the best of our knowledge, this is the first case reporting these two clinical conditions simultaneously associated with MM. PMID: 30641542 [PubMed - in process] (Source: Acta Reumatologica Portuguesa)
Source: Acta Reumatologica Portuguesa - October 1, 2018 Category: Rheumatology Authors: Santos-Faria D, Leite Silva J, Sousa-Neves J, Ramos Rodrigues J, Afonso C, Peixoto D Tags: Acta Reumatol Port Source Type: research

Haemophagocytic syndrome in Systemic Lupus Erythematosus - clues to an early diagnosis.
sta L Abstract Macrophage activation syndrome (MAS) is a rare life-threatening condition that involves excessive activation of inflammatory cells and overproduction of different cytokines. It is characterized by persistent fever, hepatosplenomegaly, cytopenias and coagulopathy. Other prominent features are hyperferritinemia and findings of activated macrophages in haemopoietic organs, often associated with multi-organ impairment. Its occurrence has been linked to numerous triggers such as viral agents, malignancy and rheumatic diseases. With overlap of clinical features, distinguishing MAS from autoimmune disease ...
Source: Acta Reumatologica Portuguesa - October 1, 2018 Category: Rheumatology Authors: Ferreira RM, Ganhão S, Mariz E, Pimenta S, Costa L Tags: Acta Reumatol Port Source Type: research

Seronegative cat scratch disease in a patient with systemic lupus erythematosus.
PMID: 30095802 [PubMed - as supplied by publisher] (Source: Acta Reumatologica Portuguesa)
Source: Acta Reumatologica Portuguesa - August 10, 2018 Category: Rheumatology Authors: Aguiar F, Martins-Rocha T, Rodrigues M, Brito I Tags: Acta Reumatol Port Source Type: research

Immunoglobulin G4-related disease with recurrent uveitis and kidney tumor mimicking childhood polyarteritis nodosa: a rare case report.
We describe herein a 7-year-old boy that presented intermittent fever. He developed arthralgia, weight loss, myalgia, skin lesions and recurrent uveitis. Skin biopsy revealed necrotizing vasculitis in medium/small sized vessels associated with septal panniculitis suggesting cPAN. Prednisone and azathioprine were administered with improvement. At 11 years, he had persistent fever and abdominal angiotomography revealed a large tumor in left kidney and he was then submitted to nephrectomy. The renal histopathology showed lymphoplasmacytic and histiocytic proliferation with extensive areas of fibrosis, and lymphomonocitic phle...
Source: Acta Reumatologica Portuguesa - July 18, 2018 Category: Rheumatology Authors: Nastri MMF, Novak GV, Sallum AEM, Campos LMA, Teixeira RAP, Silva CA Tags: Acta Reumatol Port Source Type: research

Ozone therapy for low back pain. A systematic review.
CONCLUSIONS: Only a small number of poor quality studies on ozone effect in low back pain and disc herniation were available for inclusion in our review. Nevertheless, these reported an improvement in pain and functional scores with its application. Complications, mostly minor, but potentially serious are underreported. Additional studies with adequate and consistent methodologies are needed before the role of ozone can be established in the management of low back pain. PMID: 30095803 [PubMed - as supplied by publisher] (Source: Acta Reumatologica Portuguesa)
Source: Acta Reumatologica Portuguesa - July 18, 2018 Category: Rheumatology Authors: Costa T, Linhares D, Ribeiro da Silva M, Neves N Tags: Acta Reumatol Port Source Type: research

Adherence to the recommended prevention strategies before and after a hip fragility fracture: what makes us go blind?
CONCLUSIONS: Similar to other countries, the percentage of patients receiving OT at the time and especially after a HF is extremely low. Risk estimations with FRAX® and application of current PCER should allow clinicians to introduce appropriate primary and secondary preventive measures. Comorbidities and dependence seem to be important reasons for this undertreatment. PMID: 29795053 [PubMed - as supplied by publisher] (Source: Acta Reumatologica Portuguesa)
Source: Acta Reumatologica Portuguesa - May 24, 2018 Category: Rheumatology Authors: Daniel A, Marques ML, Brites L, Torres C, Marques A, Pereira da Silva JA Tags: Acta Reumatol Port Source Type: research

Monocyte chemoattractant protein-1 promoter-2518 G allele increases renal damage in systemic lupus erythematosus patients: result from a meta-analysis.
CONCLUSION: We concluded that MCP-1 promoter-2518 G allele was a risk factor for renal damages in patients with SLE. PMID: 29704391 [PubMed - as supplied by publisher] (Source: Acta Reumatologica Portuguesa)
Source: Acta Reumatologica Portuguesa - April 27, 2018 Category: Rheumatology Authors: Luo XY, Wei Q, Chen L, Yang MH, Li K, Liu Y, Yuan GH Tags: Acta Reumatol Port Source Type: research

Identification of Key Genes and Pathways in Rheumatoid Arthritis Gene Expression Profile by Bioinformatics.
CONCLUSION: These hub genes may be used as potential targets for rheumatoid arthritis diagnosis and treatment. PMID: 29660736 [PubMed - as supplied by publisher] (Source: Acta Reumatologica Portuguesa)
Source: Acta Reumatologica Portuguesa - April 16, 2018 Category: Rheumatology Authors: Lu W, Li G Tags: Acta Reumatol Port Source Type: research

Cross-cultural adaptation and validation of the Portuguese version of the Oxford Shoulder Score (OSS).
CONCLUSION: The Portuguese OSS version presented suitable psychometric properties, in terms of reliability (internal consistency, reproducibility and measurement error) and validity (construct validity). PMID: 29518793 [PubMed - as supplied by publisher] (Source: Acta Reumatologica Portuguesa)
Source: Acta Reumatologica Portuguesa - March 8, 2018 Category: Rheumatology Authors: Gonçalves RS, Caldeira CQ, Rodrigues MV, Felícia SC, Cavalheiro LM, Ferreira PL Tags: Acta Reumatol Port Source Type: research

Validation of Oral Health Impact Profile-14 and its association with Hypossialia in a Sj ögren Syndrome Portuguese Population.
CONCLUSION: Within the limitations of this study, the OHIP-14-PT seems to be a valid and reliable instrument for measuring oral health related quality of life in patients with Sjögren´s Syndrome. Both differential and stimulated salivary flows seem to correlate negatively with age and the quality of life is significantly diminished by lower stimulated salivary flow rates. PMID: 29506016 [PubMed - as supplied by publisher] (Source: Acta Reumatologica Portuguesa)
Source: Acta Reumatologica Portuguesa - March 5, 2018 Category: Rheumatology Authors: Amaral J, Sanches C, Marques D, Vaz Patto J, Barcelos F, Mata A Tags: Acta Reumatol Port Source Type: research