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The benefit of metformin in the treatment of pediatric non-alcoholic fatty liver disease: a systematic review and meta-analysis of randomized controlled trials
Conclusion: According to the data of this meta-analysis, treatment with metformin failed to statistically improve liver enzymes but may be beneficial in the improvement of lipid parameters and insulin metabolism regulation in pediatric patients with NAFLD. As there are not enough available studies in the literature, the influence of metformin on liver ultrasonography or histology in pediatric NAFLD should be further analyzed in future studies.What is Known:• Lifestyle modification with weight loss through physical activity and dietary modification is the recommended treatment option for pediatric NAFLD.• Metformin may ...
Source: European Journal of Pediatrics - August 28, 2023 Category: Pediatrics Source Type: research

Advanced effect of curcumin and resveratrol on mitigating hepatic steatosis in metabolic associated fatty liver disease via the PI3K/AKT/mTOR and HIF-1/VEGF cascade
This study aims to investigate the effect of curcumin (Cur) and resveratrol (Res) as a potential combination therapy on MAFLD. Cur, Res and Cur+Res were tested in palmitic acid (PA)-induced-HepG2 cells. MAFLD model was established using Goto-Kakizaki rats. The animals were treated with vehicle control (model group), Cur (150 mg/kg), Res (150 mg/kg), Cur+Res (150 mg/kg, 8:2, w/w), or metformin (Met, positive control, 400 mg/kg/day) via oral gavage for 4 weeks. Wistar rats were used as the control group. Network pharmacology was conducted to elucidate the molecular actions of Cur and Res, followed by q-PCR and immunoblotting...
Source: Biomed Res - August 6, 2023 Category: Research Authors: Yuhui He Huan Wang Shiling Lin Tao Chen Dennis Chang Yibin Sun Chenxiang Wang Yang Liu Yusheng Lu Jianyuan Song Shaohua Li Wen Xu Yanxiang Lin Yanfang Zheng Xian Zhou Qiumei Huang Mingqing Huang Source Type: research

Unraveling the Interplay between Nonalcoholic Fatty Liver Disease and Polycystic Ovary Syndrome in Adolescents: Pathogenesis, Prevalence, and Management Strategies
CONCLUSIONS A meticulous approach to the prevention, detection, and treatment of NAFLD in adolescents with PCOS is paramount to mitigate further complications. The study underlines the need for ongoing research to refine our understanding and management of these interconnected metabolic disorders.PMID:37455412 | DOI:10.12659/MSM.940398
Source: Medical Science Monitor - July 17, 2023 Category: Research Authors: Kinga P ółkośnik Agnieszka Łebkowska Irina Kowalska Dariusz M Lebensztejn Source Type: research

LEAP2 is Associated with Cardiometabolic Markers, but is Unchanged by Antidiabetic Treatment in People with Prediabetes
Conclusion FP-LEAP2 is associated with body mass, impaired insulin sensitivity, liver specific enzymes and kidney function. The findings highlight the importance of LEAP2 in obesity, type 2 diabetes, and non-alcoholic fatty liver disease. FP-LEAP2 was not affected by metformin, dapaglifloxin, or exercise in this population.PMID:37436962 | DOI:10.1152/ajpendo.00023.2023
Source: American Journal of Physiology. Endocrinology and Metabolism - July 12, 2023 Category: Physiology Authors: Sarah Byberg Martin B æk Blond Stephanie Holm Hanan Amadid Lea Bruhn Nielsen Kim Katrine Bjerring Clemmensen Kristine Faerch Birgitte Holst Source Type: research

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