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Specialty: Cancer & Oncology
Condition: Autoimmune Disease
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Total 31 results found since Jan 2013.
Acquired angioedema due to C1-inhibitor-deficiency (AAE-C1-INH) - a bi-center retrospective study on diagnosis, course and therapy
CONCLUSION: AAE-C1-INH is characterized by late onset swellings mainly involving the face and low C1-INH levels. Diagnostic delay for AAE-C1-INH is further decreasing despite being about 10-fold rarer than HAE. Patients severely affected without underlying condition or no indication for treatment could benefit from off-label therapy.PMID:37716525 | DOI:10.1016/j.jaip.2023.09.003
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Felix Johnson Janina Hahn Benedikt Hofauer Jens Greve Barbara Wollenberg Thomas K Hoffmann Robin Lochbaum Susanne Trainotti Source Type: research
Perspectives on Mycophenolate Mofetil in the Management of Autoimmunity
Clin Rev Allergy Immunol. 2023 Jun 20. doi: 10.1007/s12016-023-08963-3. Online ahead of print.ABSTRACTBefore becoming a cornerstone in the treatment of numerous immune-mediated diseases, mycophenolate mofetil (MMF) was first introduced as an immunosuppressive agent in transplant immunology and later received the attention of rheumatologists and clinicians involved in the management of autoimmune diseases. MMF is now a widespread immunosuppressive drug for the treatment of several conditions, including lupus nephritis, interstitial lung disease associated with systemic sclerosis, and anti-neutrophil cytoplasm antibody (ANCA...
Source: Clinical Lung Cancer - June 20, 2023 Category: Cancer & Oncology Authors: Rithika Bhat Antonio Tonutti Suraj Timilsina Carlo Selmi M Eric Gershwin Source Type: research
The T Cell Receptor Repertoire Diversity Following Hematopoietic Stem Cell Transplantation
This study aimed to assess the T cell receptor (TCR) repertoire diversity in CD4+ cells of patients with hematological malignancies who received allogeneic or autologous HSCT. The diversity of the TCR repertoire was evaluated in 13 patients with hematologic malignancies before and four months after HSCT. Amino acid changes in the 25 Vβ families were evaluated using Spectratyping and data were presented as Hamming distance (HD). HD more than 20% was considered a change in TCR repertoire after HSCT. The mean HD was significantly changed after transplantation in all Vβ gene families, with most amino acid changes in p4 and p...
Source: Cancer Control - November 7, 2022 Category: Cancer & Oncology Authors: Fahimeh Zamani Reza Mirfakhraie Sayyed Reza Safaee Nodehi Yaghoub Mollaei-Kandelous Hossein Jafari Mohammad Farahmand Farhad Rezaei Majid Teymoori-Rad Abolfazl Movafagh Source Type: research
Nanoparticle Dose and Antigen Loading Attenuate Antigen-Specific T Cell Responses
This article is protected by copyright. All rights reserved.PMID:36221192 | DOI:10.1002/bit.28252
Source: Cancer Control - October 12, 2022 Category: Cancer & Oncology Authors: Liam M Casey Joseph T Decker Joseph R Podojil Laila Rad Kevin R Hughes Justin A Rose Ryan M Pearson Stephen D Miller Lonnie D Shea Source Type: research
Systemic Sclerosis Association with Malignancy
Clin Rev Allergy Immunol. 2022 Sep 19. doi: 10.1007/s12016-022-08930-4. Online ahead of print.ABSTRACTThe association of systemic sclerosis (SSc) and cancer is well known from several decades suggesting common genetic and environmental risk factors involved in the development of both diseases. Immunosuppressive drugs widely used in SSc may increase the risk of cancer occurrence and different SSc clinical and serological features identify patients at major risk to develop malignancy. In this context, among serological features, presence of anti-RNA polymerase III and anti-topoisomerase I autoantibodies seems to increase can...
Source: Clinical Breast Cancer - September 19, 2022 Category: Cancer & Oncology Authors: Gemma Lepri Martina Catalano Silvia Bellando-Randone Serena Pillozzi Elisa Giommoni Roberta Giorgione Cristina Botteri Marco Matucci-Cerinic Lorenzo Antonuzzo Serena Guiducci Source Type: research
Immune cell-antibody interactions in health and disease
Clin Exp Immunol. 2022 Jun 26:uxac065. doi: 10.1093/cei/uxac065. Online ahead of print.ABSTRACTThe human immune system safeguards against pathogens through a multitude of cellular and molecular signals, involving different components of the innate and adaptive response. Contrastingly, autoimmune diseases, allergic conditions and cancer evoke different aspects of these otherwise protective processes. Understanding the immunological hallmarks for each pathological setting is essential for improving prevention, diagnosis, prognosis and treatment. The activatory states of immune effector cells, especially in relation to their ...
Source: Clinical Genitourinary Cancer - June 26, 2022 Category: Cancer & Oncology Authors: Sophia N Karagiannis James N Arnold Source Type: research
Molecular Mechanisms Driving IL-10- Producing B Cells Functions: STAT3 and c-MAF as Underestimated Central Key Regulators?
Front Immunol. 2022 Mar 10;13:818814. doi: 10.3389/fimmu.2022.818814. eCollection 2022.ABSTRACTRegulatory B cells (Bregs) have been highlighted in very different pathology settings including autoimmune diseases, allergy, graft rejection, and cancer. Improving tools for the characterization of Bregs has become the main objective especially in humans. Transitional, mature B cells and plasma cells can differentiate into IL-10 producing Bregs in both mice and humans, suggesting that Bregs are not derived from unique precursors but may arise from different competent progenitors at unrestricted development stages. Moreover, in a...
Source: Cancer Control - April 1, 2022 Category: Cancer & Oncology Authors: Magalie Mich ée-Cospolite Marina Boudigou Alexis Grasseau Quentin Simon Olivier Mignen Jacques-Olivier Pers Divi Cornec La ëtitia Le Pottier Sophie Hillion Source Type: research
Maternal autoimmune disease and risk of hospitalization for autoimmune disease, allergy, and cancer in offspring
CONCLUSIONS: Maternal autoimmune disease is associated with an increased risk of autoimmune disease and allergy hospitalization in offspring, but the relationship appears to be confounded by genetic and environmental factors. Prenatal exposure to immunologic or pharmacologic products is not likely a direct cause of immune-mediated disease in children.PMID:35212046 | DOI:10.1111/pai.13728
Source: Cancer Control - February 25, 2022 Category: Cancer & Oncology Authors: Xiaotian Zhao Philippe B égin Harb Kang M élanie Henderson Antoine Lewin Ga Eun Lee Jessica Healy-Profit ós Nathalie Auger Source Type: research
