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Specialty: Rheumatology
Condition: Autoimmune Disease

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Total 81 results found since Jan 2013.

Neurological and endocrinological involvement in neonatal lupus erythematosus: a retrospective study at a tertiary hospital in Eastern China
ConclusionsAt our hospital, no significant gender differences were observed in the occurrence of NLE, and a predominance of skin, blood, liver, and heart involvement was observed. Patients with multiple central nervous system injuries and organ involvement are more likely to have growth retardation. Endocrine disorders are transient in NLE patients, and some showed feeding intolerance as the first manifestation.Key Points•A retrospective investigation of the clinical characteristics and prognosis of 39 NLE patients was performed, focusing on the clinical features of patients with neurological and endocrine system involve...
Source: Clinical Rheumatology - August 11, 2023 Category: Rheumatology Source Type: research

The association of different serum IgG4 levels with distinct clinical characteristics and treatment efficacy in patients with IgG4-related disease
CONCLUSIONS: IgG4-RD patients with different levels of serum IgG4 exhibit different clinical characteristics and treatment responses.PMID:34238402
Source: Clinical and Experimental Rheumatology - July 9, 2021 Category: Rheumatology Authors: Panpan Zhang Zheng Liu Jieqiong Li Yunyun Fei Xiaorong Wang Mu Wang Liang Zhu Huadan Xue Ruie Feng Chaojun Hu Shulan Zhang Wen Zhang Yan Zhao Xiaofeng Zeng Fengchun Zhang Source Type: research

α‐mangostin attenuates pristane‐induced lupus nephritis by regulating Th17 differentiation
ConclusionThus, α‐mangostin demonstrated its potential as a candidate therapeutic drug for LN and other Th17‐mediated autoimmune diseases by inhibiting the function of Th17.
Source: International Journal of Rheumatic Diseases - November 24, 2019 Category: Rheumatology Authors: Xiaoqing Zhou, Huanpeng Chen, Fengjiao Wei, Qingyu Zhao, Qiao Su, Yu Lei, Meng Yin, Xuyan Tian, Zhonghua Liu, Bolan Yu, Chuan Bai, Xixin He, Zhaofeng Huang Tags: ORIGINAL ARTICLE Source Type: research

Allergy inhibitory receptor ‐1 inhibits autoantibody production via upregulation of apoptotic debris clearance by macrophages
ConclusionAllergin ‐1 might play an inhibitory role in autoantibody production via upregulation of macrophage phagocytosis.
Source: International Journal of Rheumatic Diseases - December 16, 2018 Category: Rheumatology Authors: Akira Iizuka, Seiji Segawa, Yuya Kondo, Shunta Kaneko, Masahiro Yokosawa, Kotona Furuyama, Haruka Miki, Satoko Tahara ‐Hanaoka, Akira Shibuya, Hiroto Tsuboi, Daisuke Goto, Isao Matsumoto, Shiro Shibayama, Takayuki Sumida Tags: ORIGINAL ARTICLE Source Type: research

Incidence of autoimmune diseases in a nationwide HIV/AIDS patient cohort in Taiwan, 2000-2012
Conclusions PLWHA had higher risks of incident Sjögren syndrome, psoriasis, SLE, autoimmune haemolytic anaemia and uveitis.
Source: Annals of the Rheumatic Diseases - March 9, 2017 Category: Rheumatology Authors: Yen, Y.-F., Chuang, P.-H., Jen, I.-A., Chen, M., Lan, Y.-C., Liu, Y.-L., Lee, Y., Chen, Y.-H., Chen, Y.-M. A. Tags: Immunology (including allergy), Muscle disease, Ophthalmology, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Systemic lupus erythematosus Clinical and epidemiological research Source Type: research

Rheumatoid arthritis phenotype at presentation differs depending on the number of autoantibodies present
Conclusions The number of autoantibodies, reflecting the breadth of the humoral autoimmune response, is associated with the clinical presentation of RA. Predisease pathophysiology is thus reflected by the initial clinical phenotype.
Source: Annals of the Rheumatic Diseases - March 9, 2017 Category: Rheumatology Authors: Derksen, V. F. A. M., Ajeganova, S., Trouw, L. A., van der Helm-van Mil, A. H. M., Hafström, I., Huizinga, T. W. J., Toes, R. E. M., Svensson, B., van der Woude, D. Tags: Immunology (including allergy), Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis Clinical and epidemiological research Source Type: research

Targeting the RhoA-ROCK pathway to reverse T-cell dysfunction in SLE
Conclusions ROCK activity is elevated in PBMCs from patients with SLE and RA. Production of IL-17 and IL-21 by SLE T cells or Th17 cells can furthermore be inhibited by targeting the RhoA-ROCK pathway via both non-selective and selective approaches.
Source: Annals of the Rheumatic Diseases - March 9, 2017 Category: Rheumatology Authors: Rozo, C., Chinenov, Y., Maharaj, R. K., Gupta, S., Leuenberger, L., Kirou, K. A., Bykerk, V. P., Goodman, S. M., Salmon, J. E., Pernis, A. B. Tags: Immunology (including allergy), Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Systemic lupus erythematosus Basic and translational research Source Type: research

Immune cell study sheds new light on how inflammatory arthritis begins
This study, published in the medical journal Science Immunology, used multiphoton intravital microscopy - an imaging technology that allows immune cell movements to be tracked in real time - to follow the development of arthritis in lab mice withrheumatoid arthritis, in order to better understand how this works. It was revealed that the presence of immune complexes within the joint space leads to the production of a molecule called C5a, which is then displayed on the inner walls of adjacent blood vessels and causes immune cells called neutrophils to pass into the joint, setting off the process of inflammation. The implicat...
Source: Arthritis Research UK - January 25, 2017 Category: Rheumatology Source Type: news

TCR repertoire sequencing identifies synovial Treg cell clonotypes in the bloodstream during active inflammation in human arthritis
Conclusions Using an innovative antigen-agnostic approach, we uncovered a population of bona fide synovial Treg cells readily accessible from the blood and selectively expanding during active disease, paving the way to non-invasive diagnostics and better understanding of the pathogenesis of autoimmunity.
Source: Annals of the Rheumatic Diseases - January 9, 2017 Category: Rheumatology Authors: Rossetti, M., Spreafico, R., Consolaro, A., Leong, J. Y., Chua, C., Massa, M., Saidin, S., Magni-Manzoni, S., Arkachaisri, T., Wallace, C. A., Gattorno, M., Martini, A., Lovell, D. J., Albani, S. Tags: Open access, Immunology (including allergy), Inflammation, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis Basic and translational research Source Type: research

IL-7 primes IL-17 in mucosal-associated invariant T (MAIT) cells, which contribute to the Th17-axis in ankylosing spondylitis
Conclusions This study reveals a potential role for MAIT cells in patients with AS and is the first linking IL-7 to the elevated IL-17 profile in patients through the AS-associated risk gene IL7R.
Source: Annals of the Rheumatic Diseases - November 9, 2016 Category: Rheumatology Authors: Gracey, E., Qaiyum, Z., Almaghlouth, I., Lawson, D., Karki, S., Avvaru, N., Zhang, Z., Yao, Y., Ranganathan, V., Baglaenko, Y., Inman, R. D. Tags: Genetics, Immunology (including allergy), Inflammation, Ankylosing spondylitis, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Calcium and bone Basic and translational research Source Type: research

Pan PPAR agonist IVA337 is effective in prevention and treatment of experimental skin fibrosis
Conclusions These findings indicate that simultaneous activation of all three PPAR isoforms exerts a dampening effect on inflammation and fibrosis, making IVA337 a potentially effective therapeutic candidate in the treatment of fibrotic diseases including SSc.
Source: Annals of the Rheumatic Diseases - November 9, 2016 Category: Rheumatology Authors: Ruzehaji, N., Frantz, C., Ponsoye, M., Avouac, J., Pezet, S., Guilbert, T., Luccarini, J.-M., Broqua, P., Junien, J.-L., Allanore, Y. Tags: Open access, Immunology (including allergy), Inflammation, Connective tissue disease Basic and translational research Source Type: research

Parental rheumatoid arthritis and long-term child morbidity: a nationwide cohort study
Conclusions were roughly similar for children exposed to maternal clinical RA and for children only followed up to 16 years of age. Conclusion Children of parents with RA had consistent excess morbidity. If the associations reflect biological mechanisms, genetic factors seem to play an important role. These findings call for attention given to children of parents with RA.
Source: Annals of the Rheumatic Diseases - September 8, 2016 Category: Rheumatology Authors: Rom, A. L., Wu, C. S., Olsen, J., Jawaheer, D., Hetland, M. L., Ottesen, B., Morch, L. S. Tags: Immunology (including allergy), Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Epidemiology Clinical and epidemiological research Source Type: research