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Condition: Diabetes Type 2
Procedure: PET Scan

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Total 57 results found since Jan 2013.

Assessment of myocardial metabolic flexibility and work efficiency in human Type 2 diabetes using 16-18F-fluoro-4-thiapalmitate, a novel PET fatty acid tracer.
Abstract Altered myocardial fuel selection likely underlies cardiac disease risk in diabetes, affecting oxygen demand and myocardial metabolic flexibility. We investigated myocardial fuel selection and metabolic flexibility in human Type 2 Diabetes (T2DM), using positron emission tomography to measure rates of myocardial fatty acid oxidation (16-(18)F-fluoro-4-thia-palmitate, FTP), and myocardial perfusion and total oxidation ((11)C-acetate). Participants underwent paired studies under fasting conditions, comparing 3-hour insulin+glucose euglycemic clamp conditions (120 mU/m(2)/min) to 3-hour saline infusion. Lean...
Source: Am J Physiol Endocri... - January 5, 2016 Category: Endocrinology Authors: Mather KJ, Hutchins GD, Perry K, Territo W, Chisholm R, Acton A, Glick-Wilsom B, Considine RV, Moberly S, DeGrado TR Tags: Am J Physiol Endocrinol Metab Source Type: research

9 Healthy Reasons To Indulge Your Coffee Cravings
There's no need to feel guilty about your morning cup o’ joe. On the contrary: People who drink four or more cups of coffee a day have up to a 20 percent lower risk of melanoma than those who sip the dark stuff less often, according to a 2015 study in the Journal of the National Cancer Institute. But this study is hardly the first one touting good news for java junkies. "Coffee is incredibly rich in antioxidants, which are responsible for many of its health benefits," says Joy Bauer, RD, nutrition and health expert for Everyday Health and The Today Show. And studies show that its caffeine content may also play a prot...
Source: Healthy Living - The Huffington Post - September 20, 2015 Category: Consumer Health News Source Type: news

Sleep Problems May Hint At Future Heart Disease Risk
By Kathryn Doyle (Reuters Health) - Adults who get too much or too little sleep may have the beginnings of “hardening" of the arteries, which can be an early sign of heart disease, according to a new study. “Many people, up to one third or one fourth of the general population, suffer from inadequate sleep – either insufficient duration of sleep or poor quality of sleep,” said co-lead author Dr. Chan-Won Kim of Kangbuk Samsung Hospital of Sungkyunkwan University School of Medicine in Seoul, South Korea. Several studies have linked inadequate sleep with an increased risk of heart attack and stroke, bu...
Source: Healthy Living - The Huffington Post - September 10, 2015 Category: Consumer Health News Source Type: news

Plasma Levels of Soluble IL-2 Receptor α: Associations With Clinical Cardiovascular Events and Genome-Wide Association Scan.
CONCLUSIONS: These results support a role for sIL-2Rα in atherosclerosis and provide evidence for multiple-associated single-nucleotide polymorphisms at chromosome 10p15-14. PMID: 26293465 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 20, 2015 Category: Cardiology Authors: Durda P, Sabourin J, Lange EM, Nalls MA, Mychaleckyj JC, Jenny NS, Li J, Walston J, Harris TB, Psaty BM, Valdar W, Liu Y, Cushman M, Reiner AP, Tracy RP, Lange LA Tags: Arterioscler Thromb Vasc Biol Source Type: research

Prognostic impact of abdominal fat distribution and cardiorespiratory fitness in asymptomatic type 2 diabetics
Conclusions Although subcutaneous and visceral adipose tissues differed in their association with CRF levels and absolute event rates, lower baseline CRF in type 2 diabetics was significantly associated with higher risk of all-cause mortality, myocardial infarction or stroke, regardless of abdominal adiposity pattern.
Source: European Journal of Preventive Cardiology - August 10, 2015 Category: Cardiology Authors: Zafrir, B., Khashper, A., Gaspar, T., Dobrecky-Mery, I., Azencot, M., Lewis, B. S., Rubinshtein, R., Halon, D. A. Tags: Original scientific papers Source Type: research

Is type 2 diabetes related to leukoaraiosis? an updated review
A significantly increased interest has been dedicated to the study of the effects of diabetes mellitus (DM) on the brain. DM is associated with an increased risk of stroke and cognitive decline. In patients with DM, neuroimaging discloses with high‐frequency structural changes, such as cerebral atrophy, infarcts and white matter lesions, also called leukoaraiosis (LA), an expression of small vessel disease. A previous review showed a relation between DM and both cerebral atrophy and lacunar infarcts, while the question about the relation between DM and LA remained unanswered. In this review, we provide an update on data ...
Source: Acta Neurologica Scandinavica - March 1, 2015 Category: Neurology Authors: A. Del Bene, L. Ciolli, L. Borgheresi, A. Poggesi, D. Inzitari, L. Pantoni Tags: Review Article Source Type: research

Volumetric analysis of central body fat accurately predicts incidence of diabetes and hypertension in adults
Conclusions Central body fat and BMI equally and highly predict incidence of hypertension and type 2 diabetes.
Source: BMC Obesity - February 25, 2015 Category: Eating Disorders and Weight Management Source Type: research

The impact of patients' involvement in cooking on their mortality and morbidity: A 19-year follow-up of patients diagnosed with type 2 diabetes mellitus.
Conclusions. In patients newly diagnosed with T2DM and with a regular intake of warm main meals, infrequent involvement in cooking was associated with an increased risk of diabetes-related death and stroke for women, but not for men. General practitioners should pay special attention to managing diabetes treatment in female patients newly diagnosed with T2DM who report infrequent involvement in cooking. PMID: 25592166 [PubMed - as supplied by publisher]
Source: Primary Care - January 16, 2015 Category: Primary Care Authors: Jandorf S, Siersma V, Køster-Rasmussen R, Olivarius NF, Waldorff FB Tags: Scand J Prim Health Care Source Type: research

Genetic & epigenetic approach to human obesity.
Genetic & epigenetic approach to human obesity. Indian J Med Res. 2014 Nov;140(5):589-603 Authors: Rao KR, Lal N, Giridharan NV Abstract Obesity is an important clinical and public health challenge, epitomized by excess adipose tissue accumulation resulting from an imbalance in energy intake and energy expenditure. It is a forerunner for a variety of other diseases such as type-2-diabetes (T2D), cardiovascular diseases, some types of cancer, stroke, hyperlipidaemia and can be fatal leading to premature death. Obesity is highly heritable and arises from the interplay of multiple genes and environme...
Source: Indian J Med Res - November 1, 2014 Category: Research Authors: Rao KR, Lal N, Giridharan NV Tags: Indian J Med Res Source Type: research

Disassociation of verbal learning and hippocampal volume in type 2 diabetes and major depression
ConclusionsThe relationship between hippocampal volume and performance on the California Verbal Learning Test is decoupled in subjects with type 2 diabetes and major depression and this decoupling may contribute to poor verbal learning and memory performance in this study population. Copyright © 2014 John Wiley & Sons, Ltd.
Source: International Journal of Geriatric Psychiatry - June 12, 2014 Category: Geriatrics Authors: O. Ajilore, M. Lamar, J. Medina, K. Watari, V. Elderkin‐Thompson, A. Kumar Tags: Research Article Source Type: research

Blood pressure variability: A new target to slow the progression of vascular damage in type 2 diabetes?
Hypertension is a widely recognized cardiovascular risk factor. Besides the correct measurement of systolic blood pressure (BP), of paramount importance in assessing cardiovascular risk, other BP features have been suggested to play a role; among these, the visit-to-visit BP variability is receiving growing support from the scientific literature. Observational studies link BP variability with carotid artery intima media thickness and atherosclerosis (), and in aging people it worsens cardiovascular prognosis and negatively affects cognitive function (). Post-hoc analyses of large trials, like the United Kingdom Transient I...
Source: Journal of Diabetes and Its Complications - December 6, 2013 Category: Endocrinology Authors: Anna Solini Tags: Editorials Source Type: research

No evidence Nordic diet prevents heart disease
Conclusion This was a well-designed randomised controlled trial that took place across several Nordic locations. The study took careful clinical measures of elements of metabolic syndrome at several points during the trial, and used food diaries at regular intervals to check compliance to the assigned diet. However, it provides no reliable proof that the ‘healthy’ Nordic diet is any better than the ‘average’ Nordic diet at improving components of metabolic syndrome and, in turn, no proof that it reduces the risk of cardiovascular disease. Importantly, this study found no significant results for its main aim (which...
Source: NHS News Feed - May 31, 2013 Category: Consumer Health News Tags: Food/diet Lifestyle/exercise Heart/lungs Source Type: news