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Condition: Diabetes Type 2
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Total 3594 results found since Jan 2013.
Risk of New-onset Stroke in Patients with Type 2 Diabetes with Chronic Kidney Disease on Sodium-glucose Co-transporter-2 Inhibitor Users
This study aimed to examine the association between the use of SGLT2 inhibitors and NOS risk in patients with T2D and CKD. We conducted a nationwide retrospective cohort study using data from the Taiwan Health Insurance Review and Assessment Service database for the years 2004 to 2019. The primary outcome was the risk of incident stroke, which was estimated using hazard ratios (HRs) and 95% confidence intervals (CIs). We used multiple Cox regression modeling to analyze the association between SGLT2 inhibitor use and the risk of stroke in patients with T2D and CKD. In a cohort of 113,710 patients with T2D and CKD who were u...
Source: Translational Stroke Research - July 14, 2023 Category: Neurology Source Type: research
Impact of Metformin on the Severity and Outcomes of Acute Ischemic Stroke in Patients with Type 2 Diabetes Mellitus
This study evaluated the effects of metformin on stroke severity and outcomes in acute ischemic stroke patients with type 2 DM.
Source: Journal of Stroke and Cerebrovascular Diseases - December 22, 2015 Category: Neurology Authors: Yohei Mima, Takahiro Kuwashiro, Masahiro Yasaka, Yuichiro Tsurusaki, Asako Nakamura, Yoshiyuki Wakugawa, Yasushi Okada Source Type: research
Type 2 Diabetes Mellitus and Impaired Renal Function Are Associated With Brain Alterations and Poststroke Cognitive Decline Clinical Sciences
Background and Purpose—Type 2 diabetes mellitus (T2DM) is associated with diseases of the brain, kidney, and vasculature. However, the relationship between T2DM, chronic kidney disease, brain alterations, and cognitive function after stroke is unknown. We aimed to evaluate the inter-relationship between T2DM, impaired renal function, brain pathology on imaging, and cognitive decline in a longitudinal poststroke cohort.Methods—The TABASCO (Tel Aviv brain acute stroke cohort) is a prospective cohort of stroke/transient ischemic attack survivors. The volume and white matter integrity, ischemic lesions, and brain and hippo...
Source: Stroke - August 28, 2017 Category: Neurology Authors: Einor Ben Assayag, Roy Eldor, Amos D. Korczyn, Efrat Kliper, Shani Shenhar-Tsarfaty, Oren Tene, Jeremy Molad, Itzhak Shapira, Shlomo Berliner, Viki Volfson, Ludmila Shopin, Yehuda Strauss, Hen Hallevi, Natan M. Bornstein, Eitan Auriel Tags: Diabetes, Type 2, Cognitive Impairment, Ischemic Stroke, Transient Ischemic Attack (TIA) Original Contributions Source Type: research
Sodium-Glucose Cotransporter-2 Inhibitors and Protection Against stroke in Patients with type 2 Diabetes and Impaired Renal Function: A Systematic Review and Meta-Analysis
It is well established that diabetes mellitus type 2 (T2DM) is associated with increased risk of cardiovascular disease, including ischemic stroke. Among past antidiabetic agents, only pioglitazone and glucagon-like peptide 1 receptor agonists (GLP-1RA) have been shown to decrease the risk of stroke.1-5 Similarly, sodium-glucose cotransporter-2 inhibitors (SGLT2i) were expected to reduce the risk of stroke, considering their blood pressure lowering and neuroprotective effects demonstrated by experimental studies.
Source: Journal of Stroke and Cerebrovascular Diseases - March 10, 2021 Category: Neurology Authors: Fotios Barkas, Sebastian Filippas Ntekouan, Evangelos Liberopoulos, Theodosios Filippatos, Haralampos Milionis Source Type: research
Poor Outcome of Experimental Ischemic Stroke in Type 2 Diabetic Rats: Impaired Circulating Endothelial Progenitor Cells Mobilization
This study tried to investigate whether T2DM worsens the cerebral I/R injury via affecting circulating EPCs.
Source: Journal of Stroke and Cerebrovascular Diseases - March 24, 2015 Category: Neurology Authors: HongNa Yang, Shuang Ma, Ying Liu, Yi Li, Wei Wu, EnJi Han, GuoYong Jia, CuiLan Wang Source Type: research
Chronic Elevation of Tumor Necrosis Factor-{alpha} Mediates the Impairment of Leptomeningeal Arteriogenesis in db/db Mice Basic Sciences
Conclusions—
These results indicate that leptomeningeal arteriogenesis is impaired in db/db mice and that suppression of the tumor necrosis factor-α response to hypoperfusion is the major contributing factor.
Source: Stroke - May 22, 2015 Category: Neurology Authors: Yukami, T., Yagita, Y., Sugiyama, Y., Oyama, N., Watanabe, A., Sasaki, T., Sakaguchi, M., Mochizuki, H., Kitagawa, K. Tags: Cerebrovascular disease/stroke, Type 2 diabetes, Other Vascular biology Basic Sciences Source Type: research
Large-Scale Phenome-Wide Association Study of PCSK9 Variants Demonstrates Protection Against Ischemic Stroke Original Articles
Conclusions:
This result represents the first genetic evidence in a large cohort for the protective effect of PCSK9 inhibition on ischemic stroke and corroborates exploratory evidence from clinical trials. PCSK9 inhibition was not associated with variables other than those related to LDL (low-density lipoprotein) cholesterol, atherosclerosis, and type 2 diabetes mellitus, suggesting that other effects are either small or absent.
Source: Circulation: Cardiovascular Genetics - July 11, 2018 Category: Cardiology Authors: Rao, A. S., Lindholm, D., Rivas, M. A., Knowles, J. W., Montgomery, S. B., Ingelsson, E. Tags: Cardiovascular Disease, Diabetes, Type 2, Genetic, Association Studies, Ischemic Stroke Original Articles Source Type: research
Mediterranean diet 'reduces genetic stroke risk'
Scientists say they have discovered that the Mediterranean diet may prevent a genetic risk of stroke since it appears to interact with a particular gene variant usually associated with type 2 diabetes. Researchers from the Jean Mayer USDA Human Nutrition Research center on Aging (USDA HNRCA) at Tufts University, and the CIBER FisiopatologÃa de la Obesidad y NutriciÏ�n in Spain, conducted the study, which was published in the journal Diabetes Care. The research team analyzed 7,018 men and women involved in the Prevencion con Dieta Mediterranea (PREDIMED) trial...
Source: Health News from Medical News Today - August 15, 2013 Category: Consumer Health News Tags: Stroke Source Type: news
Duration of Diabetes Mellitus and Risk of Thromboembolism and Bleeding in Atrial Fibrillation: Nationwide Cohort Study Clinical Sciences
Conclusions—
In patients with atrial fibrillation, longer duration of diabetes mellitus was associated with a higher risk of thromboembolism, but not with a higher risk of anticoagulant-related bleeding. Considering the critical balance between preventing thromboembolism and avoiding bleeding, longer duration of diabetes mellitus may favor initiation of anticoagulant therapy.
Source: Stroke - July 27, 2015 Category: Neurology Authors: Overvad, T. F., Skjoth, F., Lip, G. Y. H., Lane, D. A., Albertsen, I. E., Rasmussen, L. H., Larsen, T. B. Tags: Thrombosis risk factors, Type 1 diabetes, Type 2 diabetes, Embolic stroke, Anticoagulants Clinical Sciences Source Type: research
Type 2 Diabetes and Hemorrhagic Stroke: A Population-Based Study in Spain from 2003 to 2012
The objective of this study is to compare trends in outcomes for intracerebral hemorrhagic stroke in people with or without type 2 diabetes in Spain between 2003 and 2012.
Source: Journal of Stroke and Cerebrovascular Diseases - March 22, 2016 Category: Neurology Authors: Nuria Muñoz-Rivas, Manuel Méndez-Bailón, Valentín Hernández-Barrera, José Mª de Miguel-Yanes, Rodrigo Jimenez-Garcia, Jesus Esteban-Hernández, Ana Lopez-de-Andrés Source Type: research
Increased Vascular Disease Mortality Risk in Prediabetic Korean Adults Is Mainly Attributable to Ischemic Stroke Clinical Sciences
Background and Purpose—Prediabetes is a known risk factor for vascular diseases; however, its differential contribution to mortality risk from various vascular disease subtypes is not known.Methods—The subjects of the National Health Insurance Service in Korea (2002–2013) nationwide cohort were stratified into normal glucose tolerance (fasting glucose
Source: Stroke - March 27, 2017 Category: Neurology Authors: Nam Hoon Kim, Tae Yeon Kwon, Sungwook Yu, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Yousung Park, Sin Gon Kim Tags: Cardiovascular Disease, Diabetes, Type 2, Epidemiology, Ischemic Stroke Original Contributions Source Type: research
Letter by Castilla-Guerra et al Regarding Article, “Pioglitazone for Secondary Stroke Prevention: A Systematic Review and Meta-Analysis” Letter to the Editor
Source: Stroke - April 24, 2017 Category: Neurology Authors: Luis Castilla–Guerra, Maria del Carmen Fernandez–Moreno, Jose Antonio Perez de Leon Tags: Diabetes, Type 2, Risk Factors, Secondary Prevention, Cerebrovascular Disease/Stroke, Vascular Disease Letters to the Editor Source Type: research
Letter by Iguchi and Nango Regarding Article, “Pioglitazone for Secondary Stroke Prevention: A Systematic Review and Meta-Analysis” Letter to the Editor
Source: Stroke - June 26, 2017 Category: Neurology Authors: Masahiro Iguchi, Eishu Nango Tags: Diabetes, Type 2, Secondary Prevention, Cerebrovascular Disease/Stroke Letters to the Editor Source Type: research
Guidelines for Stroke Survivors With Diabetes Mellitus State-of-the-Science Nursing Reviews
Source: Stroke - May 25, 2018 Category: Neurology Authors: Trudy Gaillard, Elaine Miller Tags: Diabetes, Type 2, Nursing, Cerebrovascular Disease/Stroke State-of-the-Science Nursing Reviews Source Type: research
Cell-Based Therapies for Stroke: Promising Solution or Dead End? Mesenchymal Stem Cells and Comorbidities in Preclinical Stroke Research
Conclusion
The high prevalence of comorbidities in patients with stroke indicates the need for therapies in preclinical studies that take into account these comorbidities in order to avoid failures in translation to the patient. Preclinical studies are beginning to evaluate the efficacy of MSC treatment in stroke associated with comorbidities, especially hypertension, for ischemic and hemorrhagic stroke. Regarding aging and diabetes, only ischemic stroke studies have been performed. For the moment, few studies have been performed and contradictory results are being reported. These contradictory results may be due to the u...
Source: Frontiers in Neurology - April 8, 2019 Category: Neurology Source Type: research
