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Fight Aging! Newsletter, September 11th 2023
This article reviews the current regulatory role of miR-7 in inflammation and related diseases, including viral infection, autoimmune hepatitis, inflammatory bowel disease, and encephalitis. It expounds on the molecular mechanism by which miR-7 regulates the occurrence of inflammatory diseases. Finally, the existing problems and future development directions of miR-7-based intervention on inflammation and related diseases are discussed to provide new references and help strengthen the understanding of the pathogenesis of inflammation and related diseases, as well as the development of new strategies for clinical interventi...
Source: Fight Aging! - September 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Metformin-suppressed platelet's function in vitro: Possible relation to delayed or failure of platelet-rich fibrin preparation
Toxicol In Vitro. 2023 Sep 4;93:105692. doi: 10.1016/j.tiv.2023.105692. Online ahead of print.ABSTRACTPlatelet-rich fibrin (PRF) is a popular autologous blood-derived biomaterial that is used in regenerative therapy. Owing to its simple preparation without additional factors, the PRF quality directly reflects the characteristics of individual blood samples. Antiplatelet or anticoagulant drugs can hamper the successful preparation of PRF. We recently observed similar phenomena in metformin-taking type-2 diabetics (T2DM). Thus, we hypothesized that metformin interferes with platelet function, thereby suppressing coagulation....
Source: Toxicology in Vitro - September 6, 2023 Category: Toxicology Authors: Takashi Uematsu Hideo Masuki Masayuki Nakamura Hideo Kawabata Yutaka Kitamura Taisuke Watanabe Takao Watanabe Tomoharu Mochizuki Takashi Ushiki Tomoyuki Kawase Source Type: research
Promising translatable pharmacological interventions for body weight management in individuals with severe mental illness - a narrative review
Expert Opin Pharmacother. 2023 Aug 31. doi: 10.1080/14656566.2023.2254698. Online ahead of print.ABSTRACTINTRODUCTION: Psychotropic medications, especially antipsychotics, have been consistently shown to cause weight gain in individuals with severe mental illness (SMI), a population inherently challenged with poor physical health. Consequently, compared to the general population, this contributes to an increased cardiometabolic burden, including the risk of type 2 diabetes, dyslipidemia, and hypertension. Furthermore, comorbid obesity leads to treatment nonadherence, decreased quality of life, and increased risk of relapse...
Source: Expert Opinion on Pharmacotherapy - September 1, 2023 Category: Drugs & Pharmacology Authors: Riddhita De Femin Prasad Nicolette Stogios Luisa Burin Bj ørn H Ebdrup Filip K Knop Margaret K Hahn Sri Mahavir Agarwal Source Type: research
Metformin and SGLT2i as First-line Combination Therapy in Type 2 Diabetes: A Real-world Study With a Focus on Ethnicity
Clin Ther. 2023 Aug 28:S0149-2918(23)00302-8. doi: 10.1016/j.clinthera.2023.07.026. Online ahead of print.ABSTRACTPURPOSE: Suboptimal glucose control early in the diagnosis of type 2 diabetes (T2D) is strongly associated with subsequent morbidity and mortality, termed the 'glycaemic legacy'. Additionally, it is known that Asian and Black individuals are at increased risk of T2D, and its associated complications compared to their White counterparts. However, ethnicity does not currently feature in the treatment algorithm of T2D, unlike in other cardiovascular disease states such as hypertension. We therefore sought to evalu...
Source: Clinical Therapeutics - August 30, 2023 Category: Drugs & Pharmacology Authors: Matthew Anson Sizheng Steven Zhao Hani Essa Philip Austin Gema Hern ández Ibarburu Gregory Y H Lip Uazman Alam Source Type: research
A hospital-based assessment of glycemic control and medication adherence in type 2 diabetes mellitus in Eastern Nepal
CONCLUSION: The majority of the diabetic patients had good glycemic control and medium MA. Patients taking regular fruit, being involved in daily jogging, having a shorter duration of drug therapy, and having good diabetic knowledge were identified as factors that affect both glycemic control and MA.PMID:37636174 | PMC:PMC10451609 | DOI:10.4103/jfmpc.jfmpc_90_23
Source: Primary Care - August 28, 2023 Category: Primary Care Authors: Deependra Prasad Sarraf Pramendra Prasad Gupta Source Type: research
