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Condition: Chronic Kidney Disease
Drug: Acetic Acid
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Total 63 results found since Jan 2013.
Saikosaponin A protects against uremic toxin indole ‑3 acetic acid‑induced damage to the myocardium
Mol Med Rep. 2023 Sep;28(3):159. doi: 10.3892/mmr.2023.13046. Epub 2023 Jul 7.ABSTRACTChronic kidney disease (CKD)‑associated cardiac injury is a common complication in patients with CKD. Indole‑3 acetic acid (IAA) is a uremic toxin that injures the cardiovascular system. Saikosaponin A (SSA) protects against pressure overload‑induced cardiac fibrosis. However, the role and molecular mechanisms of IAA and SSA in CKD‑associated cardiac injury remain unclear. The present study investigated the effects of IAA and SSA on CKD‑associated cardiac injury in neonatal mouse cardiomyocytes and a mouse model of CKD. The expr...
Source: Molecular Medicine - July 7, 2023 Category: Molecular Biology Authors: Cheng Chen Xiaoyuan Hu Xinguang Chen Source Type: research
Synthesis and structural characterization of xylan acetate ester and its antinephritic effects in rats with experimental chronic kidney disease
Int J Biol Macromol. 2023 Apr 12:124413. doi: 10.1016/j.ijbiomac.2023.124413. Online ahead of print.ABSTRACTAcetic acid has been shown to be effective in chronic kidney disease (CKD). However, it is a low-molecular-weight compound that allows it to be absorbed in the upper digestive tract so that it cannot function in colon. To overcome these deficiencies, an acetate-releasing xylan derivative, xylan acetate ester (XylA), was synthesized and selected in this study for its potential in the treatment of CKD. IR, NMR and HPGPC were used to characterize the structure of XylA and its antinephritic effects was evaluated in vivo....
Source: International Journal of Biological Macromolecules - April 14, 2023 Category: Biochemistry Authors: Zhengqi Zha Xiaoning Wang Guoqing Wang Hongping Yin Hang Wang Source Type: research
Therapeutic effects of CORM3 and NaHS in chronic kidney disease induced cognitive impairment via the interaction between carbon monoxide and hydrogen sulfide on Nrf2/HO-1 signaling pathway in rats
In conclusion, this study demonstrated that formation of CO and H2S were interdependently improved CKD-induced cognitive dysfunctions, through interaction with Nrf2/HO-1 signaling pathway.PMID:36252702 | DOI:10.1016/j.cbi.2022.110217
Source: Chemico-Biological Interactions - October 17, 2022 Category: Molecular Biology Authors: Zeinab Hamidizad Mehri Kadkhodaee Seyed Morteza Karimian Mina Ranjbaran Fatemeh Heidari Enayatollah Bakhshi Farzaneh Kianian Elham Zahedi Behjat Seifi Source Type: research
Dietary therapy with low protein genmai (brown rice) to improve the gut-kidney axis and reduce CKD progression
Asia Pac J Clin Nutr. 2022;31(3):341-347. doi: 10.6133/apjcn.202209_31(3).0001.ABSTRACTLow protein rice can be part of a nutritionally adequate dietary pattern in the prevention of chronic kidney disease. We developed a low protein fermented genmai (brown rice) LPFG) to improve chronic kidney disease (CKD) management. The principal functional features of brown rice are retained in LPFG, lessening the negative spiral of gut-kidney associative spiral attributable to uremic dysbiosis and a leaky gut. LPFG is characterized by (1) an energy value the same as white rice, (2) a protein content less than 0.2 g/ 100 g, (3) a potass...
Source: Asia Pacific Journal of Clinical Nutrition - September 29, 2022 Category: Nutrition Authors: Shaw Watanabe Kyoka Adachi Shu Wakino Takahisa Hisada Jun Mochizuki Source Type: research
