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Phenotypic and Endotypic Determinants of Atopic Dermatitis Severity from the ADRN Registry
CONCLUSION: In a diverse US AD population, severity was associated with a history of atopic disorders, skin and extracutaneous bacterial and viral infections (by history and physical examination), higher IgE, eosinophilia and allergen sensitization, atopic skin manifestations (i.e., excoriation, hyperlinear palms and ichthyosis), and atopic ocular features (i.e., blepharitis, conjunctivitis, and ectropion) as well as asthma findings (i.e., wheezing). Data from our prospective registry significantly advances our understanding of AD phenotypes and endotypes, which is critical to achieve optimal management.PMID:37182563 | DOI...
Source: Herpes - May 14, 2023 Category: Infectious Diseases Authors: Eric L Simpson Anna De Benedetto Mark Boguniewicz Peck Y Ong Stephanie Lussier Miguel Villarreal Lynda C Schneider Amy S Paller Emma Guttman-Yassky Jon M Hanifin Jonathan M Spergel Kathleen C Barnes Gloria David Briahnna Austin Donald Y M Leung Lisa A Bec Source Type: research

Effect of Disease Severity on Comorbid Conditions in Atopic Dermatitis: Nationwide Registry-Based Investigation in Finnish Adults
Acta Derm Venereol. 2023 Mar 8;103:adv00882. doi: 10.2340/actadv.v103.4447.ABSTRACTThe majority of registry studies on atopic dermatitis include only patients and diagnoses from specialized healthcare. The aim of this retrospective, real-world cohort study was to evaluate the effect of atopic dermatitis severity on comorbidities and total morbidity, with comprehensive data from both primary and specialty healthcare registries covering the entire Finnish adult population. In total, 124,038 patients were identified (median age 46 years; 68% female) and stratified by disease severity. All regression analyses (median follow-up...
Source: Acta Derm Venereol A... - March 8, 2023 Category: Dermatology Authors: Ville Kiiski Liisa Ukkola-Vuoti Johanna Vikkula Martta Ranta Mariann I Lassenius Jaakko Kopra Source Type: research

Factors associated with severity of atopic dermatitis - a Finnish cross-sectional study
CONCLUSIONS: Severity determinants in Finnish patients seem to be early-onset, male sex, smoking, overweight, concomitant asthma, palmar hyperlinearity, hand dermatitis and high IgE-levels. A sub-typing of patients in relation to confirmed severity determinants may be useful for course prediction, prognosis, and targeted AD management.PMID:35766133 | DOI:10.1111/jdv.18378
Source: Herpes - June 29, 2022 Category: Infectious Diseases Authors: A Salava V Salo J Lepp änen A Lauerma A Remitz Source Type: research

Dupilumab-induced peripheral neuropathy in a patient with severe asthma
The anti –interleukin (IL)-4 receptor, an antibody dupilumab is used in the treatment of severe asthma, atopic dermatitis, and chronic rhinosinusitis with nasal polyps. Common adverse events reportedly include injection site reactions, conjunctivitis, headache, and oral herpes. Dr Lee et al1 provided the f irst reported case of very severe chronic inflammatory demyelinating polyradiculoneuropathy that developed 1.5 years after the initiation of dupilumab treatment for atopic dermatitis. Similarly, we have encountered a case of peripheral neuropathy in a patient with severe asthma being treated with du pilumab and wish to...
Source: Annals of Allergy, Asthma and Immunology - April 28, 2022 Category: Allergy & Immunology Authors: Mayuka Yamane, Hiroshi Ohnishi, Kimiko Tsuji, Kazuki Anabuki, Akihito Yokoyama Tags: Correspondence Source Type: research

M002 new-onset rosacea in a patient on dupilumab treatment for nasal polyposis
Dupilumab is a humanized monoclonal antibody that inhibits the interleukin-4 receptor (IL-4R α), thereby blocking IL-4 and IL-13 signaling of the Th2 pathway. Via Th2 blockade, Dupilumab decreases eosinophil recruitment, rendering it an effective treatment for nasal polyps caused by chronic accumulation of eosinophils in the paranasal sinus mucosa. Side effects reported during clinical tri als included conjunctivitis, injection site reactions, and herpes infections.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2021 Category: Allergy & Immunology Authors: J. Fortier, J. Justice, A. Debenedetto, L. Cuervo-Pardo Source Type: research

Use of Topical Steroids in Conjunctivitis: A Review of the Evidence
Conclusions: Corticosteroids, in combination with anti-infectives, could be a promising treatment option for acute conjunctivitis subject to development of further evidence on their effectiveness and safety in conjunctivitis treatment.
Source: Cornea - July 9, 2019 Category: Opthalmology Tags: Review Source Type: research