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Condition: Asthma
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Total 404 results found since Jan 2013.
Melatonin MT < sub > 2 < /sub > receptor is expressed and potentiates contraction in human airway smooth muscle
Am J Physiol Lung Cell Mol Physiol. 2021 Oct 6. doi: 10.1152/ajplung.00273.2021. Online ahead of print.ABSTRACTNocturnal asthma is characterized by heightened bronchial reactivity at night, and plasma melatonin concentrations are higher in patients with nocturnal asthma symptoms. Numerous physiological effects of melatonin are mediated via its specific G protein-coupled receptors (GPCRs) named the MT1 receptor which couples to both Gq and Gi proteins, and the MT2 receptor which couples to Gi. We investigated whether melatonin receptors are expressed on airway smooth muscle, whether they regulate intracellular cyclic AMP (c...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - October 6, 2021 Category: Cytology Authors: Haruka Sasaki Yi Zhang Charles W Emala Kentaro Mizuta Source Type: research
RSV Promotes Epithelial Neuroendocrine Phenotype Differentiation through NODAL Signaling Pathway
CONCLUSION: RSV promotes epithelial neuroendocrine phenotypes through the NODAL signaling pathway.PMID:34541002 | PMC:PMC8445725 | DOI:10.1155/2021/9956078
Source: Biomed Res - September 20, 2021 Category: Research Authors: Dan Liu Zhongxiang Tang Kezi Qiu Ousman Bajinka Lili Wang Ling Qin Yurong Tan Source Type: research
Zileuton inhibits arachidonate-5-lipoxygenase to exert antitumor effects in preclinical cervical cancer models
ConclusionsOur work demonstrates that the ALOX5-5-HETE axis is activated in cervical cancer, with important roles in growth and survival, and this can be therapeutically targeted by zileuton. Our findings also provide preclinical evidence to assess the efficacy of zileuton in cervical cancer in clinical settings.
Source: Cancer Chemotherapy and Pharmacology - September 3, 2021 Category: Cancer & Oncology Source Type: research
The Pathogenesis of Eosinophilic Asthma: A Positive Feedback Mechanism That Promotes Th2 Immune Response via Filaggrin Deficiency
In conclusion, in the Th2 cytokine milieu of asthma, FLG deficient mutation in airway epithelial cells may increase the epithelial permeability and the expression of IL-33/TSLP which positively feedback the Th2 inflammation response.
Source: Frontiers in Immunology - August 13, 2021 Category: Allergy & Immunology Source Type: research
Pref-1 induced lung fibroblast differentiation by hypoxia through integrin α5β1/ERK/AP-1 cascade
Eur J Pharmacol. 2021 Jul 28:174385. doi: 10.1016/j.ejphar.2021.174385. Online ahead of print.ABSTRACTChronic obstructive asthma is characterized by airway fibrosis. Hypoxia and connective tissue growth factor (CTGF) play important roles in airway fibrosis. Preadipocyte factor-1 (Pref-1) participates in adipocyte differentiation and liver fibrosis. Herein, we investigated the role of Pref-1 in airway fibrosis in chronic obstructive asthma. We found that Pref-1 was overexpressed in lung tissues from chronic obstructive asthma patients compared to normal subjects. Extracellular matrix proteins were inhibited by Pref-1 small ...
Source: European Journal of Pharmacology - July 31, 2021 Category: Drugs & Pharmacology Authors: Wun-Hao Cheng Kang-Yun Lee Ming-Chih Yu Jing-Yun Chen Chien-Huang Lin Bing-Chang Chen Source Type: research
Diacylglycerol Kinase Inhibition Reduces Airway Contraction by Negative Feedback Regulation of Gq-signaling
Am J Respir Cell Mol Biol. 2021 Jul 22. doi: 10.1165/rcmb.2021-0106OC. Online ahead of print.ABSTRACTExaggerated airway smooth muscle (ASM) contraction regulated by the Gq family of G protein-coupled receptors (GPCRs) causes airway hyperresponsiveness (AHR) in asthma. Activation of Gq-coupled GPCRs leads to phospholipase C (PLC)-mediated generation of inositol triphosphate (IP3) and diacylglycerol (DAG). DAG signaling is terminated by the action of DAG kinase (DGK) that converts DAG into phosphatidic acid (PA). Our previous study demonstrated that DGKα and ζ isoform knockout mice are protected from the development of all...
Source: Am J Respir Cell Mol... - July 22, 2021 Category: Respiratory Medicine Authors: Pawan Sharma Santosh K Yadav Sushrut D Shah Elham Javed John M Lim Shi Pan Ajay P Nayak Reynold A Panettieri Raymond B Penn Taku Kambayashi Deepak A Deshpande Source Type: research
