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Spray drying siRNA-lipid nanoparticles for dry powder pulmonary delivery
This study verifies the successful spray drying procedure of LNP-siRNA systems maintaining their integrity and mediating strong gene silencing efficiency on mRNA and protein levels both in vitro and ex vivo. The successful spray drying procedure of LNP-siRNA formulations in 5% lactose solution creates a novel siRNA-based therapy option to target respiratory diseases such as lung cancer, asthma, COPD, cystic fibrosis and viral infections.PMID:36126785 | DOI:10.1016/j.jconrel.2022.09.021
Source: Cancer Control - September 20, 2022 Category: Cancer & Oncology Authors: Christoph M Zimmermann Domizia Baldassi Karen Chan Nathan B P Adams Alina Neumann Diana Leidy Porras-Gonzalez Xin Wei Nikolaus Kneidinger Mircea Gabriel Stoleriu Gerald Burgstaller Dominik Witzigmann Paola Luciani Olivia M Merkel Source Type: research

Zileuton inhibits arachidonate-5-lipoxygenase to exert antitumor effects in preclinical cervical cancer models
ConclusionsOur work demonstrates that the ALOX5-5-HETE axis is activated in cervical cancer, with important roles in growth and survival, and this can be therapeutically targeted by zileuton. Our findings also provide preclinical evidence to assess the efficacy of zileuton in cervical cancer in clinical settings.
Source: Cancer Chemotherapy and Pharmacology - September 3, 2021 Category: Cancer & Oncology Source Type: research

MID1 –PP2A complex functions as new insights in human lung adenocarcinoma
ConclusionsWe demonstrated that the MID1 –PP2A complex plays an important role in lung adenocarcinoma, influencing cell cycle progression, proliferation and apoptosis. Our findings showed a novel molecular mechanism of lung tumorigenesis that may provide new insights for anti-tumor therapies.
Source: Journal of Cancer Research and Clinical Oncology - February 15, 2018 Category: Cancer & Oncology Source Type: research

MID1-PP2A complex functions as new insights in human lung adenocarcinoma.
CONCLUSIONS: We demonstrated that the MID1-PP2A complex plays an important role in lung adenocarcinoma, influencing cell cycle progression, proliferation and apoptosis. Our findings showed a novel molecular mechanism of lung tumorigenesis that may provide new insights for anti-tumor therapies. PMID: 29450633 [PubMed - indexed for MEDLINE]
Source: Clinical Lung Cancer - May 1, 2018 Category: Cancer & Oncology Authors: Zhang L, Li J, Lv X, Guo T, Li W, Zhang J Tags: J Cancer Res Clin Oncol Source Type: research

Montelukast, a cysteinyl leukotriene receptor antagonist, inhibits the growth of chronic myeloid leukemia cells through apoptosis.
Authors: Zovko A, Yektaei-Karin E, Salamon D, Nilsson A, Wallvik J, Stenke L Abstract The clinical outcome for patients with chronic myeloid leukemia (CML) has improved significantly with the introduction of tyrosine kinase inhibitors (TKIs). However, their curative potential appears limited, probably as a consequence of TKI-resistant leukemic stem cells (LSCs) that persist as a result of aberrant pathways independent of the well-established oncoprotein Bcr-Abl. One such pathway involves signaling through leukotrienes (LTs), bioactive compounds that have been suggested to play a role in several other malignancies. ...
Source: Oncology Reports - June 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

15LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type-2 inflammation
J Clin Invest. 2021 Nov 11:e151685. doi: 10.1172/JCI151685. Online ahead of print.ABSTRACTAltered redox biology challenges all cells, with compensatory responses often determining a cell's fate. When 15 lipoxygenase-1 (15LO1), a lipid peroxidizing enzyme abundant in asthmatic human airway epithelial cells (HAECs), binds phosphatidylethanolamine binding protein-1 (PEBP1), hydroperoxy-phospholipids, which drive ferroptotic cell death, are generated. Peroxidases, including glutathione peroxidase-4 (GPX4), metabolize hydroperoxy-phospholipids to hydroxy derivatives to prevent ferroptotic death, but consume reduced glutathione ...
Source: Clinical Lung Cancer - November 11, 2021 Category: Cancer & Oncology Authors: Tadao Nagasaki Alexander J Schuyler Jinming Zhao Svetlana N Samovich Kazuhiro Yamada Yanhan Deng Scott P Ginebaugh Stephanie A Christenson Prescott G Woodruff John V Fahy John B Trudeau Detcho Stoyanovsky Anuradha Ray Yulia Y Tyurina Valerian E Kagan Sall Source Type: research