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Condition: Asthma
Therapy: Chemotherapy
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Total 152 results found since Jan 2013.
Cytokine profiling, pretreatment with anakinra, and tolerance development in platinum-induced mixed hypersensitivity reactions
CONCLUSION: In patients with platinum-induced CRR, anakinra could be a useful premedication to block its clinical manifestations, and monitoring of IL-2, IL-5, IL-6, IL-10 and TNF-a could help predict tolerance development thereby allowing safe adjustments to the desensitization protocol and premedication.PMID:37321446 | DOI:10.1016/j.anai.2023.06.011
Source: Annals of Allergy, Asthma and Immunology - June 15, 2023 Category: Allergy & Immunology Authors: Matthieu Picard Charles Alexandre Filion Marie-H élène Auclair Jonathan Noujaim Lara de Guerk é Jean-Luc Dionne Julie Beaudet Carl Amireault Suzanne Fortin Source Type: research
Drug allergy biomarkers
Although the true burden of drug allergy is unknown, several studies indicate that adverse drug reactions occur in up to 6% to 10% of hospitalized patients —20% of which are because of drug allergy—and up to 10% of the general population claims to have penicillin or other drug allergies.1 A plethora of new antibiotics, vaccines, chemotherapy drugs, and, more recently, biologicals and targeted molecular drugs are available and have improved disease treatment options, but drug allergy remains a vexing and unaddressed problem that deprives patients of the best medication for their disease, and when re-exposed, places them...
Source: Annals of Allergy, Asthma and Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Mariana Castells Tags: Editorial Source Type: research
Hypersensitivity reactions to folinic acid: mechanisms involved based on two case reports and a literature review
CONCLUSIONS: These two cases of anaphylaxis to FA document the clinical manifestations associated with two different mechanisms of HSR. This paper provided the opportunity to review the limited literature on HSR to FA. Through these cases, we hope to draw the practitioner's attention to FA as a potential agent of severe hypersensitivity, especially if symptoms remain after withdrawing the most suspected chemotherapeutic agents. We want also to stress the importance of allergy testing.PMID:36550565 | PMC:PMC9783773 | DOI:10.1186/s13223-022-00752-5
Source: Clinical Colorectal Cancer - December 22, 2022 Category: Cancer & Oncology Authors: Matve ï Apraxine Marc Van den Eynde Astrid De Cuyper Fran çoise Pirson Source Type: research
How Some COVID-Cautious Experts Are Celebrating Thanksgiving
America’s third pandemic Thanksgiving may feel like the most normal holiday gathering in a while. AAA expects travel over the long weekend to reach 98% pre-pandemic levels, with an estimated 54.6 million people driving and flying to see loved ones. In fact, 2022 is on track to be the third busiest Thanksgiving since AAA started tracking these travel numbers in 2000.
At the beginning of the pandemic, celebrating Thanksgiving meant either virtual or very small in-person gatherings. Now that COVID-19 vaccines and medications are available, it makes it easier to see more family, “which is a beautiful thing,” ...
Source: TIME: Health - November 18, 2022 Category: Consumer Health News Authors: Kyla Mandel Tags: Uncategorized COVID-19 healthscienceclimate Source Type: news
IL-6 and Cytokine Release Syndrome: a new understanding in drug hypersensitivity reactions
Ann Allergy Asthma Immunol. 2022 Nov 4:S1081-1206(22)01905-6. doi: 10.1016/j.anai.2022.10.025. Online ahead of print.ABSTRACTImmediate drug hypersensitivity reactions (DHRs) are historically thought to be due to IgE cross-linking, causing mast cell degranulation and release of mediators like tryptase and histamine. With the increasing use of monoclonal antibodies, it has become apparent that some patients present atypical features during immediate DHRs, including occurrence in initial exposure, a lack of urticaria and angioedema, and presence of fever, chills rigors and musculoskeletal pain as the predominant symptoms. Thi...
Source: Annals of Allergy, Asthma and Immunology - November 7, 2022 Category: Allergy & Immunology Authors: Erika Yue Lee Baruch D Jakubovic Source Type: research
Molecular Characteristics of Bladder Tumor: Increased Gene Expression of MAGE-A6 and MAGE-A11 with Decreased MicroRNA-34a and MicroRNA-125b
Iran J Allergy Asthma Immunol. 2022 Oct 26;21(5):561-573. doi: 10.18502/ijaai.v21i5.11043.ABSTRACTBladder cancer is recognized as one of the top ten most common cancers worldwide. Activation of oncogenes, inactivation of tumor suppressor genes, and dysregulation of androgen signaling pathways are three major pathophysiological causes in the development of bladder tumors. Discovering potential biomarkers is required for the management and immunotherapy of bladder cancer. Melanoma-associated antigen (MAGE)-A6 and MAGE-A11 are two cancer-testis antigens that are potential coregulators of androgen receptors. MicroRNAs, especia...
Source: Iranian Journal of Allergy, Asthma and Immunology - November 7, 2022 Category: Allergy & Immunology Authors: Azin Aghamajidi Zahra Ousati Ashtiani Monireh Mohsenzadegan Nader Tajik Mahmood Ghafoori Yazdi Laleh Sharifi Mohammad Reza Nowroozi Source Type: research
