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Condition: Asthma
Drug: Amoxicillin
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Total 99 results found since Jan 2013.
Allergists are critical to a holistic approach to penicillin delabeling
Penicillin allergy evaluation has undergone a dramatic shift in the last 15 years. Direct amoxicillin challenges without prior penicillin skin testing are the preferred evaluation modality in pediatric and adult patients with a history of remote or benign cutaneous reactions.1 The benefits of penicillin allergy delabeling in those without a true allergy are well described. Direct benefits for the patient include reducing risk for treatment failure, Clostridium difficile infection, surgical site infections, and adverse side effects.
Source: Annals of Allergy, Asthma and Immunology - June 30, 2023 Category: Allergy & Immunology Authors: Margaret Redmond Tags: Editorial Source Type: research
Clavulanic Acid Is a Leading Culprit Beta-Lactam in Immediate Allergic Reactions to Penicillins
CONCLUSIONS: Selective immediate reactions to clavulanate accounted for over a third of cases with confirmed reactions after amoxicillin-clavulanate intake, with more than half experiencing anaphylaxis. Within this group, skin test sensitivity was below 50%. People taking amoxicillin-clavulanate may also be co-sensitized to both drugs.PMID:37021506 | DOI:10.4168/aair.2023.15.2.201
Source: Allergy, Asthma and Immunology Research - April 6, 2023 Category: Allergy & Immunology Authors: Isabel Torres-Rojas Diana P érez-Alzate Maria Luisa Somoza Ana Prieto-Moreno Pfeifer Elisa Haroun Diaz Teodorikez W Jimenez-Rodriguez Javier Fern ández Sánchez Francisco J Ruano Miguel Blanca Natalia Blanca-L ópez Source Type: research
Penicillin allergy delabelling in a pediatric primary care setting
We report the initial results of a prospective pilot study of pediatric primary care-driven direct amoxicillin challenges in delabeling penicillin allergy.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: G. Patel, J. Feng, T. Chow, D. Khan Tags: 2021 Community Grant Recipient Source Type: research
Influence of the early-life gut microbiota on the immune responses to an inhaled allergen
Mucosal Immunol. 2022 Jul 16. doi: 10.1038/s41385-022-00544-5. Online ahead of print.ABSTRACTAntibiotics, among the most used medications in children, affect gut microbiome communities and metabolic functions. These changes in microbiota structure can impact host immunity. We hypothesized that early-life microbiome alterations would lead to increased susceptibility to allergy and asthma. To test this, mouse pups between postnatal days 5-9 were orally exposed to water (control) or to therapeutic doses of azithromycin or amoxicillin. Later in life, these mice were sensitized and challenged with a model allergen, house dust m...
Source: Cancer Control - July 16, 2022 Category: Cancer & Oncology Authors: Timothy C Borbet Miranda B Pawline Xiaozhou Zhang Matthew F Wipperman Sebastian Reuter Timothy Maher Jackie Li Tadasu Iizumi Zhan Gao Megan Daniele Christian Taube Sergei B Koralov Anne M üller Martin J Blaser Source Type: research
Amoxicillin hypersensitivity: patient outcomes in a seven-year retrospective study
CONCLUSION: The negative predictive value of skin tests in both immediate and non-immediate hypersensitivity reactions is excellent and excludes severe allergy. Non-immediate hypersensitivity is rare. Confirmed hypersensitivity is more likely if amoxicillin-clavulanic acid is the index drug. Cross-reactivity was more common in patients presenting with immediate hypersensitivity, most commonly involving benzylpenicillin. A minority of patients were allergic to clavulanic acid.PMID:35788420 | DOI:10.1016/j.anai.2022.06.021
Source: Annals of Allergy, Asthma and Immunology - July 5, 2022 Category: Allergy & Immunology Authors: Xingyue Maria Wang Lucinda Kennard Krzysztof Rutkowski Maria Eduarda Ferreira Bruco Rita Mirakian Annette Wagner Source Type: research
