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The Predictive Capacity of the Buffalo Concussion Treadmill Test After Sport-Related Concussion in Adolescents
Conclusion This study found that the ΔHR (HRt minus resting HR) correlated with duration of clinical recovery in participants who were prescribed relative rest or a placebo-stretching program but not for participants prescribed sub-threshold aerobic exercise. A ΔHR of ≤50 bpm on the BCTT was 73% sensitive and 78% specific for predicting delayed recovery in concussed adolescents prescribed the current standard of care (i.e., cognitive and physical rest). This has implications for planning team and school activities in adolescents who sustain SRC. Ethics Statement This study was carried out in acco...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

Pre-injury Comorbidities Are Associated With Functional Impairment and Post-concussive Symptoms at 3- and 6-Months After Mild Traumatic Brain Injury: A TRACK-TBI Study
Conclusions: Pre-injury psychiatric and pre-injury headache/migraine symptoms are risk factors for worse functional and post-concussive outcomes at 3- and 6-months post-mTBI. mTBI patients presenting to acute care should be evaluated for psychiatric and headache/migraine history, with lower thresholds for providing TBI education/resources, surveillance, and follow-up/referrals. Clinical Trial Registration: www.ClinicalTrials.gov, identifier NCT01565551. Introduction Traumatic brain injury (TBI) remains a significant cause of morbidity and mortality worldwide. In 2013 ~2.8 million TBI cases were recorded an...
Source: Frontiers in Neurology - April 8, 2019 Category: Neurology Source Type: research

Isotropic Generalized Diffusion Tensor MRI
Scientists at the Eunice Kennedy Shriver National Institute for Child Health and Human Development (NICHD) have developed a method implemented as pulse sequences and software to be used with magnetic resonance imaging (MRI) scanners and systems. This technology is available for licensing and commercial development. The method allows for measuring and mapping features of the bulk or average apparent diffusion coefficient (ADC) of water in tissue – aiding in stroke diagnosis and cancer therapy assessment. The pulse sequences and software enable MRI scanners to yield diffusion weighted images (DWI) that are orientationally ...
Source: NIH OTT Licensing Opportunities - August 16, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

BrainScope Receives Prix Galien Award Nomination for Its Concussion and Traumatic Brain Injury Assessment Product
BETHESDA, Md.--BrainScope today announced its second consecutive nomination for the 2018 Annual Prix Galien USA Awards for “Best Medical Technology” product. Its flagship BrainScope One product is a multi-modal, comprehensive, handheld capability to help clinicians objectively and rapidly assess and triage head injured patients directly at the point of care. BrainScope’s innovative technology addresses a vast market need for the global epidemic of mild head injury, which impacts more people each year than stroke and heart failure combined. BrainScope One is the first FDA-cleared medical device to ...
Source: JEMS: Journal of Emergency Medical Services News - August 2, 2018 Category: Emergency Medicine Authors: Brainscope Tags: Trauma Product Announcements News Industry News Source Type: news

Biomarkers can reveal traumatic brain injury, even when concussions don ’t show up on CAT scan
FINDINGSUCLA researchers have identified four biomarkers that could help doctors diagnose brain trauma and concussions through a simple blood test. The biomarkers are proteins, from brain cells called astrocytes, which are released instantly into the bloodstream when astrocytes ’ outer membranes rupture from blunt impact or whiplash trauma.BACKGROUNDMild traumatic brain injuries, also called concussions, often go undiagnosed, but they can lead to lasting neurological impairment, especially after repeated occurrences.Currently, doctors use CT scans or a standard scoring system to describe the level of consciousness in a p...
Source: UCLA Newsroom: Health Sciences - October 27, 2017 Category: Universities & Medical Training Source Type: news

The Medical Emergency Of Otto Warmbier
All that the doctors who treated Cincinnati, Ohio resident Otto Warmbier knew is what they had seen or maybe read in the news. They knew he had just been released on June 13 from imprisonment in North Korea where he had been held by for more than 17 months. He had been sentenced in March 2016 to 15 years of hard labor for allegedly removing a propaganda poster from a wall at a Pyongyang hotel where he had been staying. The University of Virginia honors student had been visiting the authoritarian state during a five-day trip with a group called Young Pioneer Tours, which is a group out of China – an important note. Ot...
Source: Healthy Living - The Huffington Post - June 22, 2017 Category: Consumer Health News Source Type: news

Mapping Traumatic Brain Injuries
There's been an increasing amount of media attention to the topic of Traumatic Brain Injury (TBI) -bolstered in part by conversations surrounding the 2015 Hollywood blockbuster Concussion. The movie Concussion describes a particular phenomenon, Chronic Traumatic Encephalopathy or CTE, which occurs in the brain after repeated high impact blows to the head. The diagnosis of CTE requires examining brain tissue under a microscope after death, so it can't be diagnosed in living individuals. But in fact, there are many types of TBI, with concussion being the mildest (but most common) form. Today, brain mapping techniques are mak...
Source: Science - The Huffington Post - January 17, 2017 Category: Science Source Type: news

MRI scan may help diagnose chronic traumatic encephalopathy, UCLA researchers report
UCLA doctors have found what may be an earlier and easier way to diagnose chronic traumatic encephalopathy, or CTE, a disorder that is thought to affect some former football players and others with a history of repetitive brain trauma. Using a new software tool for analyzing MRI scans, the researchers detected the shrinkage of several key brain regions in a former football player with cognitive problems. The same pattern of brain changes is commonly seen in CTE cases that have been confirmed by autopsies after a person’s death. While the findings from this single case report are preliminary, they raise the possibility th...
Source: UCLA Newsroom: Health Sciences - August 24, 2016 Category: Universities & Medical Training Source Type: news

Can concussion be tested for with a 'simple' blood test?
Conclusion This study is a prospective cohort study that aimed to investigate the use of two proteins in the blood – GFAP and UCH-L1 – as markers for detecting mild to moderate traumatic brain injury. The study found both proteins could be present in the blood after a head injury, with higher levels of UCH-L1 in the early stages after injury, while GFAP seemed to be a good marker for up to a week after injury. But both biomarkers were not found in all cases. One in five people with a brain injury did not have detectable levels of GFAP, and 1 in 10 did not have UCH-L1. This substantially reduces their ability to be us...
Source: NHS News Feed - March 29, 2016 Category: Consumer Health News Tags: Medical practice Neurology Source Type: news

No proof heading footballs causes brain damage
Conclusion Overall, this research provides no evidence that there is a direct cause and effect between repeated heading of a football and traumatic brain injury. However, there are several important limitations to this study that are worth noting. One-off tests and scans of players The people in the study only had brain images and neurological tests at one point in time, and were asked about heading in the previous year and if they had any concussions in their lifetime. Without having the imaging and neurological tests prior to the year in question – or preferably in early periods of life, before they started playing f...
Source: NHS News Feed - June 12, 2013 Category: Consumer Health News Tags: Lifestyle/exercise Neurology Source Type: news