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Soluble epoxide hydrolase inhibition alleviates inflammation in cigarette smoke-induced experimental COPD irrespective of dietary fat content
Conclusion: Both amount and composition of dietary fats impact disease features in COPD. Inhibition of sEH reduced airway inflammation and may prove useful as a therapeutic strategy.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Rehman, S. F., Budden, K. F., Quaranta, A., Fuchs, D., Shukla, S. D., Brown, A., Alemao, C., Balachandra, L., Gomez, H., Kumar, V., Idrees, S., Horvat, J., Wood, L. G., Wheelock, C., Hansbro, P. M. Tags: 05.03 - Allergy and immunology Source Type: research

Nutritional Factors in Occupational Lung Disease
AbstractPurpose of ReviewLung diseases such as asthma and COPD are major public health issues and related to occupational exposures. While therapies to limit the development and progression of these diseases are limited, nutrition interventions could offer potential alternatives to mediate the inflammation associated with these diseases. This is a narrative review of the current state of relevant nutrients on inflammation and respiratory outcomes associated with occupational exposures.Recent FindingsRelevant nutrients that have been investigated in recent years include omega-3 polyunsaturated fatty acids, zinc, vitamin D, ...
Source: Current Allergy and Asthma Reports - March 25, 2021 Category: Allergy & Immunology Source Type: research

Osteoporosis and Sarcopenia Increase Frailty Syndrome in the Elderly
Conclusions World population is aging and the increase in life expectancy is often unhealthy. In particular, musculoskeletal aging, which leads to sarcopenia and osteoporosis, has several causes such as changes in body composition, inflammation, and hormonal imbalance. Sarcopenia, osteoporosis, and more frequently, sarcopenic obesity are commonly associated with aging and frequently closely linked each other, often leading to the development of a frailty syndrome. Frailty syndrome favors an increased risk of loss function in daily activities, for cardiovascular diseases, cancers, falls, and mortality. As the number of eld...
Source: Frontiers in Endocrinology - April 23, 2019 Category: Endocrinology Source Type: research