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Medication Adherence in Medicare Enrolled Older Adults with Asthma Before and During the COVID-19 Pandemic
CONCLUSION: Adherence to asthma controller medications significantly decreased during the COVID-19 pandemic among Medicare enrolled patients with asthma. Patients with markers for more severe asthma, overuse of albuterol, and a 90-day supply of controller medications were more likely to have high adherence. These findings can be used to identify opportunities to improve adherence and prescribing among adult patients with asthma.PMID:35227901 | PMC:PMC8873040 | DOI:10.1016/j.anai.2022.02.010
Source: Annals of Allergy, Asthma and Immunology - March 1, 2022 Category: Allergy & Immunology Authors: Olivia L Ramey Armando Silva Almod óvar Milap C Nahata Source Type: research

Role of Aspergillus fumigatus sensitization in Patients with Asthma- COPD Overlap compared to asthma patients
Conclusionsensitization to Aspergillus was more among ACO patients compared to Asthma and control groups.
Source: QJM - October 1, 2021 Category: Internal Medicine Source Type: research

Real-world Study Characterizing Patients Prior to Receiving Albuterol Multidose Dry Powder Inhaler or Short-acting β2-Agonist Via Pressurized Metered-Dose Inhalers for Asthma and COPD in the United States
Short-acting β2 agonists (SABA) are administered primarily using pressurized metered-dose inhalers (pMDIs). Albuterol multidose dry powder inhaler (MDPI; ProAir RespiClick®), a novel, breath-actuated device, eliminates hand-breath coordination required of pMDIs. A gap exists in understanding real-world differe nces in patients prior to receiving albuterol MDPI or SABA pMDI.
Source: Journal of Allergy and Clinical Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Gregory Bensch, Emily D. Parker, Rinat Ariely, Stanislav Stoyanov, Karthik Ramakrishnan Source Type: research

P236 Comorbidities associated with poor short-acting beta-agonist inhaler handling among united states respiratory patients
This study evaluated the prevalence of comorbidities potentially affecting device handling in asthma and/or COPD patients using SABAs, including albuterol multidose dry powder inhaler (MDPI), the only MDPI not requiring hand-breath coordination.
Source: Annals of Allergy, Asthma and Immunology - October 27, 2017 Category: Allergy & Immunology Authors: K. Ramakrishnan, B. Chipps, E. Parker, R. Ariely, R. Parikh, S. Stoyanov Source Type: research

LATE-BREAKING ABSTRACT: Corticosteroid responsiveness in COPD
Introduction: The mechanism of bronchodilator nonresponsiveness to corticosteroids in COPD is unclear; the levels of histone deacytylase (HDAC) and oxidative stress have been implicated (New Engl J Med, 2005;352:1967). Phosphodiesterase (PDE4) inhibition of glucocorticoid resistance in human alveolar macrophages has also been shown to reverse corticosteroid resistance (Clin Exp Allergy. 2011;41:535)Aims and objectives: We therefore studied the effects of theophylline which is believed to increase HDAC levels, as well as roflumilast, a PDE inhibitor, on steroid responsiveness in COPD.Methods: Eight COPD patients (4 Males, M...
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Burki, N., Granger, M., Datta, D. Tags: 5.1 Airway Pharmacology and Treatment Source Type: research

Historical cohort study examining comparative effectiveness of albuterol inhalers with and without integrated dose counter for patients with asthma or chronic obstructive pulmonary disease
Source: Journal of Asthma and Allergy - August 26, 2016 Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research

Long-acting muscarinic antagonist use in adults with asthma: real-life prescribing and outcomes of add-on therapy with tiotropium bromide
Conclusion: In this real-life asthma population, addition of LAMA therapy was associated with significant decreases in the incidence of exacerbations and antibiotic prescriptions for lower respiratory tract infections in the following year. Keywords: anticholinergic, bronchodilator, exacerbation, asthma control, oral corticosteroids
Source: Journal of Asthma and Allergy - January 14, 2015 Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research