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Condition: Non-alcoholic Fatty Liver Diseases (NAFLD)
Procedure: Liver Transplant
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Total 556 results found since Jan 2013.
Emerging therapeutic options for non-alcoholic fatty liver disease: A systematic review
CONCLUSION: The data analyzed in this review showed clinically significant improvement in individual histological features of NAFLD in both animal and human trials for all four classes, as well as good safety profiles (P < 0.05). We believe this compilation of information will have positive clinical implications in obtaining an FDA-approved therapy for NAFLD.PMID:37701920 | PMC:PMC10494562 | DOI:10.4254/wjh.v15.i8.1001
Source: World Journal of Hepatology - September 13, 2023 Category: Gastroenterology Authors: Jasmine Tidwell Natalie Balassiano Anjiya Shaikh Mahmoud Nassar Source Type: research
Resistant starch decreases intrahepatic triglycerides in patients with NAFLD via gut microbiome alterations
Cell Metab. 2023 Sep 5;35(9):1530-1547.e8. doi: 10.1016/j.cmet.2023.08.002.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic dysfunction for which effective interventions are lacking. To investigate the effects of resistant starch (RS) as a microbiota-directed dietary supplement for NAFLD treatment, we coupled a 4-month randomized placebo-controlled clinical trial in individuals with NAFLD (ChiCTR-IOR-15007519) with metagenomics and metabolomics analysis. Relative to the control (n = 97), the RS intervention (n = 99) resulted in a 9.08% absolute reduction of intrahepatic triglyceride...
Source: Cell Metabolism - September 6, 2023 Category: Cytology Authors: Yueqiong Ni Lingling Qian Sara Leal Siliceo Xiaoxue Long Emmanouil Nychas Yan Liu Marsena Jasiel Ismaiah Howell Leung Lei Zhang Qiongmei Gao Qian Wu Ying Zhang Xi Jia Shuangbo Liu Rui Yuan Lina Zhou Xiaolin Wang Qi Li Yueliang Zhao Hani El-Nezami Aimin Xu Source Type: research
Fight Aging! Newsletter, August 28th 2023
In conclusion, we identified 20 genes with significant evolutionary signals unique to long-lived species, which provided new insight into the lifespan extension of mammals and might bring new strategies to extend human lifespan.
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Trials of Xenotransplantation of Pig Organs into Humans Continue
https://www.fightaging.org/archives/2023/08/trials-of-xenotransplantation-of-pig-organs-into-humans-continue/
Researchers have genetically engineered pigs to overcome the known barriers to transplantation of pig organs into humans, and have reached the stage of conducting transplants in...
Source: Fight Aging! - August 27, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Management of Metabolic-Associated Fatty Liver Disease
Endocrinol Metab Clin North Am. 2023 Sep;52(3):547-557. doi: 10.1016/j.ecl.2023.02.002. Epub 2023 Mar 21.ABSTRACTMetabolic-associated fatty liver disease (MAFLD), previously known as nonalcoholic fatty liver disease (NAFLD), is the most common cause of liver disease in the world. Its prevalence is over 30% and is becoming the most common cause of liver transplants. Rates are rising along with obesity-related diseases. Risk factors for MAFLD include adverse lifestyles, genetic variations, advancing age, male sex, and alterations in the gut microbiota. Extrahepatic complications include cardiovascular disease, renal dysfunct...
Source: Clinical Colorectal Cancer - July 26, 2023 Category: Cancer & Oncology Authors: Kirthika Venkatesan Nisha Nigil Haroon Source Type: research
Emerging Therapies and Therapeutic Targets for Composite Liver Disease: NASH
CONCLUSION: Efforts have been made to provide an update on research in the area of NASH, including the pharmacological agents that are currently undergoing clinical trials for the treatment of NASH. Besides the massive research, still, gaps and challenges are there in the drug development for NASH that also have been discussed.PMID:37455455 | DOI:10.2174/1568026623666230714113808
Source: Current Topics in Medicinal Chemistry - July 17, 2023 Category: Chemistry Authors: M Elizabeth Sobhia Sonia Kumari Harish Kumar Akshata Gandhe Dhriti Kaushik Harish Kumar Jethender Jain None Ankita Moyim Mallick Bommana Pavani Mridula Moudgil Deepesh Patel Source Type: research
