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Multiple Sclerosis Exacerbation Presenting as Stress Cardiomyopathy (P6.162)
Conclusions: Stress cardiomyopathy is increasingly suspected to be neurogenic in etiology. This case not only supports this theory, but also reports multiple sclerosis to be a potential cause of neurologic dysfunction leading to this cardiac phenomenon. In addition, it fortifies the theory that bilateral medullary lesions are required for many instances of autonomic dysfunction.Disclosure: Dr. Webb has nothing to disclose. Dr. Reyna has nothing to disclose. Dr. Blair has nothing to disclose. Dr. Foreman has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Webb, T., Reyna, T., Blair, R., Foreman, R. Tags: Multiple Sclerosis Symptoms and Comorbidities Source Type: research

Generalized Dilative Arteriopathy without Myopathy: A New Phenotype of Pompe Disease (P6.256)
Conclusion. This case demonstrates that LOPD may present as an isolated generalized dilative arteriopathy with repeated kidney and brain infarcts, and no myopathy. Pompe disease should be systematically screened in patients with generalized dilative arteriopathy.Disclosure: Dr. Echaniz-Laguna has received personal compensation for activities with Sanofi-Aventis Pharmaceuticals, Inc. Dr. Bataillard has nothing to disclose. Dr. Quenardelle has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Echaniz-Laguna, A., Bataillard, M., Quenardelle, V. Tags: Cerebrovascular Disease and Interventional Neurology: Case Reports Source Type: research

Heterogeneous phenotypic manifestations of maternally inherited deafness associated with the mitochondrial A3243G mutation. Case report.
Abstract The A3243G mutation is one of the most frequent mutations of mitochondrial DNA. The phenotypic expression of the A3243G mutation is variable and causes a wide range of syndromic and non-syndromic clinical disorders. Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome is the most frequent syndromic manifestation of the A3243G mutation. Stroke-like episodes seem to be the dominant feature of MELAS. We have investigated the case of a family with A3243G mutation, in which a dominant symptom in three generations was the maternally inherited hearing loss with absenc...
Source: Neurologia i Neurochirurgia Polska - March 1, 2014 Category: Neurology Authors: Hoptasz M, Szczuciński A, Losy J Tags: Neurol Neurochir Pol Source Type: research

Takotsubo cardiomyopathy following subarachnoid haemorrhage.
Abstract A 67-year-old woman was admitted with aneurysmal subarachnoid haemorrhage and a 12-lead ECG showed ST segment elevation. Transthoracic echocardiography confirmed akinesis of the left ventricular mid-apical segment, with an ejection fraction of 26%, features characteristic of takotsubo cardiomyopathy. Five days later, we identified thrombus in the apex of the left ventricle. Sixteen days after onset, the thrombus had disappeared and wall motion improved (ejection fraction 58%) without evidence of cardioembolism. Takotsubo cardiomyopathy is a cause of cardiac dysfunction after stroke, including SAH. It is c...
Source: Practical Neurology - October 7, 2013 Category: Neurology Authors: Maekawa H, Hadeishi H Tags: Pract Neurol Source Type: research

Cerebral Embolic Stroke after Disappearing Takotsubo Cardiomyopathy
Takotsubo cardiomyopathy can induce cerebral embolic stroke because of intracardiac thrombosis, but the timing of cardiogenic embolism relating to takotsubo cardiomyopathy has not been well described. We evaluated a 71-year-old woman with takotsubo cardiomyopathy, who developed cardiogenic cerebral embolism after recovery of cardiac wall motion. Nevertheless, we treated her with anticoagulation therapy. The present clinical observation suggests that attention should be paid to the timing when takotsubo cardiomyopathy resolves against risk of cardiogenic cerebral embolism.
Source: Journal of Stroke and Cerebrovascular Diseases - August 19, 2013 Category: Neurology Authors: Kosuke Matsuzono, Yoshio Ikeda, Shoko Deguchi, Toru Yamashita, Tomoko Kurata, Kentaro Deguchi, Koji Abe Tags: Case Reports Source Type: research

Etiology of first‐ever ischaemic stroke in European young adults: the 15 cities young stroke study
ConclusionsThe etiology of IS in young adults has clear gender‐specific patterns that change with age. A notable portion of these patients remains without an evident stroke mechanism according to TOAST criteria.
Source: European Journal of Neurology - July 10, 2013 Category: Neurology Authors: N. Yesilot Barlas, J. Putaala, U. Waje‐Andreassen, S. Vassilopoulou, K. Nardi, C. Odier, G. Hofgart, S. Engelter, A. Burow, L. Mihalka, M. Kloss, J. Ferrari, R. Lemmens, O. Coban, E. Haapaniemi, N. Maaijwee, L. Rutten‐Jacobs, A. Bersano, C. Cereda, P. Tags: Original Article Source Type: research

Serendipitous Recanalization of Basilar Artery Occlusion
Conclusions: Tenecteplase has enhanced biochemical and pharmacokinetic properties that may be ideal for treatment of basilar artery occlusion and should be further investigated in a randomized clinical trial.
Source: Journal of Stroke and Cerebrovascular Diseases - July 8, 2013 Category: Neurology Authors: Jeffrey A. Switzer, Scott E. Forseen, Askiel Bruno, David C. Hess Tags: Case Reports Source Type: research

Atrial fibrillation in young stroke patients: do we underestimate its prevalence?
ConclusionAF may be more common than expected in young patients with IS and is associated with increased NIHSS scores.
Source: European Journal of Neurology - May 17, 2013 Category: Neurology Authors: D. Prefasi, P. Martínez‐Sánchez, A. Rodríguez‐Sanz, B. Fuentes, D. Filgueiras‐Rama, G. Ruiz‐Ares, B. E. Sanz‐Cuesta, E. Díez‐Tejedor Tags: Original Article Source Type: research

Determinants of White Matter Hyperintensity Burden in Patients with Fabry Disease (P03.171)
CONCLUSIONS: In FD subjects, the severity of cerebrovascular disease manifested by MRI-detectable WMH is greater than that of general population. WMH burden is associated with CMP in this cohort independently of age, and it may be affected by different disease processes in men and women and at different disease stages. Further studies exploring associations between WMHV, ERT, age- and gender-specific characteristics, as well as longitudinal WMH progression are warranted.Supported by: Genzyme, Sanofi Company; NIH-NINDS K23NS064052.Disclosure: Dr. Rost has received personal compensation for activities with Genzyme Corporatio...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Rost, N., Metterville, D., Cloonan, L., Fitzpatrick, K., Kanakis, A., Politei, J., Sims, K. Tags: P03 Cerebrovascular Disease III Source Type: research

Cerebral Infarction in Both Carotid and Vertebrobasilar Territories Associated with a Persistent Primitive Hypoglossal Artery with Severe Dilated Cardiomyopathy
A persistent primitive hypoglossal artery (PPHA) is a relatively rare vascular anomaly of a persistent carotid–basilar anastomosis. A 76-year-old man with severe dilated cardiomyopathy suddenly lost consciousness. A magnetic resonance imaging scan of his brain revealed extensive infarction in the carotid and vertebrobasilar territories. Magnetic resonance angiography revealed a PPHA and occlusion of the left internal carotid artery and vertebrobasilar artery. Cardioembolic infarction associated with a PPHA should be recognized as a possible cause of multiple infarctions in both the carotid and vertebrobasilar distributio...
Source: Journal of Stroke and Cerebrovascular Diseases - September 10, 2012 Category: Neurology Authors: Hiroyuki Kawano, Yuichiro Inatomi, Teruyuki Hirano, Toshiro Yonehara Tags: Case Reports Source Type: research

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