Filtered By:
Condition: Polyps

This page shows you your search results in order of relevance. This is page number 11.

Order by Relevance | Date

Total 2492 results found since Jan 2013.

The role of regulatory T cells in the regulation of upper airway inflammation.
Abstract Allergic rhinitis (AR) and chronic rhinosinusitis with nasal polyps (CRSwNP) are inflammatory diseases of the upper airway, with a similar immunologic profile, characterized by aberrant and persistent type 2 inflammation. One cell population that has been identified as altered in both disease types is regulatory T cell (Treg). Tregs have the capacity to modulate T-effector function and suppress inflammatory cytokine production in a broad range of cell types. Given the ability of Tregs to control inflammation, the role of Tregs in respiratory diseases has attracted much attention. As discussed in this arti...
Source: American Journal of Rhinology and Allergy - November 1, 2017 Category: ENT & OMF Authors: Palmer C, Mulligan JK, Smith SE, Atkinson C Tags: Am J Rhinol Allergy Source Type: research

How often is sinus surgery performed for chronic rhinosinusitis with versus without nasal polyps?
CONCLUSION: Almost 30% of ESS were performed for CRSwNP, and these cases were, on average, more extensive, used more OR time, and more often used image guidance than surgeries for CRSsNP. The rate of surgery performed for CRSwNP varied based on geography, payer, and surgical volume, which indicted that patient selection impacted surgical management. PMID: 29336288 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - January 1, 2018 Category: ENT & OMF Authors: Ference EH, Suh JD, Tan BK, Smith SS Tags: Am J Rhinol Allergy Source Type: research

Role of group 2 innate lymphocytes in aspirin-exacerbated respiratory disease pathogenesis.
Abstract Aspirin-exacerbated respiratory disease (AERD) is characterized by chronic eosinophilic nasal polyps, asthma, and airway reactions upon cyclooxygenase (COX) 1 inhibition. AERD is present in up to 7% of adult patients with asthma and the underlying pathogenesis remains largely elusive but prostaglandin D2, cysteinyl leukotrienes, mast cells, and type 2 cytokines are thought to contribute. A wealth of studies have recently implicated group 2 innate lymphoid cells (ILC2), a novel lineage-negative lymphocyte population that produces type 2 cytokines, in human allergic disease pathogenesis. Importantly, our re...
Source: American Journal of Rhinology and Allergy - January 1, 2018 Category: ENT & OMF Authors: White AA, Doherty TA Tags: Am J Rhinol Allergy Source Type: research

Naive and effector B-cell subtypes are increased in chronic rhinosinusitis with polyps.
CONCLUSION: Our study identified increased frequencies of different B-cell subtypes in the mucosa of patients with CRSwNP but not in the peripheral blood. We also found that patients with CRSwNP had significantly increased B-cell subtypes compared with the patients with CRSsNP and the controls. These results implied a potential role for mucosal B cells in the ongoing inflammation in patients with CRSwNP. PMID: 29336281 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - January 1, 2018 Category: ENT & OMF Authors: Miljkovic D, Psaltis A, Wormald PJ, Vreugde S Tags: Am J Rhinol Allergy Source Type: research

Age-related prevalence of chronic rhinosinusitis and nasal polyps and their relationships with asthma onset.
CONCLUSION: This study found distinct age-related patterns of CRSwNP and asthma and demonstrated their significant associations in a general population. However, low prevalence of asthma in CRSwNP is in sharp contrast to the findings in Western populations, which warrants further investigation for ethnic or regional difference in CRSwNP-asthma relationships. PMID: 29432969 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - February 9, 2018 Category: Allergy & Immunology Authors: Won HK, Kim YC, Kang MG, Park HK, Lee SE, Kim MH, Yang MS, Chang YS, Cho SH, Song WJ Tags: Ann Allergy Asthma Immunol Source Type: research

Understanding the Propensity for Chronic Sinusitis in Patients on Immunosuppressive Therapy.
Conclusion CRSi patients exhibit histopathology and disease severity more similar to CRSsNP with trends toward increased neutrophilia and reduced fibrosis. In the appropriate clinical context, discontinuing or changing a patient's immunosuppressive regimen may be a valid treatment option in patients with CRSi. This study provides initial insight into understanding the propensity for chronic sinusitis in patients undergoing immunosuppressive treatment which may have implications on disease management. PMID: 30152239 [PubMed - as supplied by publisher]
Source: American Journal of Rhinology and Allergy - August 28, 2018 Category: ENT & OMF Authors: Papagiannopoulos P, Kuhar HN, Raman A, Ganti A, Gattuso P, Batra PS, Tajudeen BA Tags: Am J Rhinol Allergy Source Type: research

Differential Hrd1 Expression and B-Cell Accumulation in Eosinophilic and Non-eosinophilic Chronic Rhinosinusitis With Nasal Polyps.
CONCLUSIONS: Differential Hrd1 expression and B-cell accumulation between the ECRS and non-ECRS subsets suggests that they can exhibit distinct pathogenic mechanisms and play important roles in NP. PMID: 30306751 [PubMed]
Source: Allergy, Asthma and Immunology Research - October 13, 2018 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Chronic Rhinosinusitis-Could Phenotyping or Endotyping Aid Therapy?
CONCLUSION: Endotyping can allow for the identification of groups of patients with CRS with a high likelihood of successful treatment, such as patients with a moderate type 2 immune reaction or those with acquired immune deficiency. PMID: 30353741 [PubMed - as supplied by publisher]
Source: American Journal of Rhinology and Allergy - October 24, 2018 Category: ENT & OMF Authors: Bayar Muluk N, Cingi C, Scadding GK, Scadding G Tags: Am J Rhinol Allergy Source Type: research

Histopathologic Features of Chronic Sinusitis Precipitated by Odontogenic Infection.
CONCLUSION: CRSo exhibits histopathologic features similar to those of CRSsNP with more severe inflammation. Moreover, eosinophilia, which is not typically considered to coexist with CRSo, was present in a large portion of CRSo patients. These findings may help explain at the inflammatory level why select cases of CRSo may be recalcitrant to medical and dental therapy. PMID: 30430853 [PubMed - as supplied by publisher]
Source: American Journal of Rhinology and Allergy - November 15, 2018 Category: ENT & OMF Authors: Raman A, Papagiannopoulos P, Kuhar HN, Gattuso P, Batra PS, Tajudeen BA Tags: Am J Rhinol Allergy Source Type: research

NAVIGATE I: Randomized, Placebo-Controlled, Double-Blind Trial of the Exhalation Delivery System With Fluticasone for Chronic Rhinosinusitis With Nasal Polyps.
CONCLUSIONS: In patients with chronic rhinosinusitis with NP (CRSwNP) who were symptomatic despite high rates of prior intranasal steroid use and/or surgery, EDS-FLU produced statistically significant and clinically meaningful improvements compared to EDS-placebo in multiple subjective and objective outcomes (symptoms, SNOT-22, RSDI, SF-36, PGIC, and NP grade), including all 4 cardinal symptoms of CRSwNP. PMID: 30477309 [PubMed - as supplied by publisher]
Source: American Journal of Rhinology and Allergy - November 27, 2018 Category: ENT & OMF Authors: Sindwani R, Han JK, Soteres DF, Messina JC, Carothers JL, Mahmoud RA, Djupesland PG Tags: Am J Rhinol Allergy Source Type: research

Biologic Agents for the Treatment of Chronic Rhinosinusitis With Nasal Polyps.
CONCLUSION: These treatments have promising results and may prove to be an important adjunct for patients with recalcitrant sinus disease. PMID: 30587005 [PubMed - as supplied by publisher]
Source: American Journal of Rhinology and Allergy - December 27, 2018 Category: ENT & OMF Authors: Kartush AG, Schumacher JK, Shah R, Patadia MO Tags: Am J Rhinol Allergy Source Type: research

Comparison Between Signature Cytokines of Nasal Tissues in Subtypes of Chronic Rhinosinusitis.
CONCLUSIONS: Commonly upregulated mediators in NP were Th2-associated, compared with UP regardless of CRS subtypes, whereas signature markers were distinct in each NP subtype. These findings imply that Th2 inflammatory responses may play a role in the development of NP regardless of CRSwNP subtypes. PMID: 30661312 [PubMed]
Source: Allergy, Asthma and Immunology Research - January 22, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Tissue and Exosomal Serine Protease Inhibitors Are Significantly Overexpressed in Chronic Rhinosinusitis With Nasal Polyps.
CONCLUSION: Our analysis supported that protease inhibitors of the fibrinolysis pathway, especially SerpinB2, SerpinF2, and SerpinG1, are highly deranged in patients with CRSwNP. These findings suggest a downregulation of the fibrinolysis pathway via proteolytic cascade imbalance leading to excessive polyp fibrin deposition. Our data further supported our hypothesis that exosomal proteomic analyses may be used as noninvasive "liquid biopsy" for CRSwNP and a novel method to study chronic sinonasal inflammation. PMID: 30810048 [PubMed - as supplied by publisher]
Source: American Journal of Rhinology and Allergy - February 27, 2019 Category: ENT & OMF Authors: Mueller SK, Nocera AL, Dillon ST, Libermann TA, Wendler O, Bleier BS Tags: Am J Rhinol Allergy Source Type: research

Expression of IL-25, IL-33, and Thymic Stromal Lymphopoietin in Nasal Polyp Gland Duct Epithelium in Patients With Chronic Rhinosinusitis.
CONCLUSION: Cytokine expression in nasal duct cells and eosinophilic infiltration around duct cells similar to those in the nasal mucosa occurred in the nasal epithelium of polyps, suggesting its role in inducing eosinophilic inflammation. PMID: 30873846 [PubMed - as supplied by publisher]
Source: American Journal of Rhinology and Allergy - March 14, 2019 Category: ENT & OMF Authors: Nagata Y, Maruoka S, Gon Y, Mizumura K, Kishi H, Nomura Y, Hikichi M, Hashimoto S, Oshima T Tags: Am J Rhinol Allergy Source Type: research

No Differences in Nasal Tissue Inflammatory Cells and Adhesion Molecules (iCAM-1 and vCAM-1) Based on the Comparison of EGPA With Eosinophilic Chronic Sinusitis With Polyposis.
CONCLUSIONS: We do not have yet blood or tissue markers able to differentiate the early phase of EGPA from chronic rhinosinusitis with nasal polyps. Further investigations are mandatory considering EGPA patients at their initial diagnosis and before any treatment, in terms of nasal histology and blood inflammatory cells, to identify markers characterizing sinonasal mucosa inflammation and useful for an early diagnosis of EGPA. PMID: 30905163 [PubMed - as supplied by publisher]
Source: American Journal of Rhinology and Allergy - March 24, 2019 Category: ENT & OMF Authors: Brescia G, Schiavon F, Nicolè L, Zanoletti E, Zanotti C, Padoan R, Felicetti M, Parrino D, Cinetto F, Cangiano D, Giacomelli L, Cappellesso R, Martini A, Fassina A, Marioni G Tags: Am J Rhinol Allergy Source Type: research