Filtered By:
Condition: Polyps
This page shows you your search results in order of relevance. This is page number 10.
Order by Relevance | Date
Total 2492 results found since Jan 2013.
Monoclonal antibody therapy in sinonasal disease.
Abstract
Chronic rhinosinusitis (CRS) affects 12.5% of the U.S.
POPULATION: CRS can be divided into CRS with nasal polyps (CRSwNP) and CRS without nasal polyps. Some individuals with CRSwNP do not respond to standard-of-care medical and surgical management. For these individuals, targeted biologic agentsare emerging as an important therapeutic alternative. In this review, we described the most-relevant studies that addressed the use of anti-immunoglobulin E (omalizumab), anti-interleukin 5 (mepolizumab and reslizumab), and anti-interleukin 4/interleukin 13 (dupilumab) monoclonal antibodies for the treatment o...
Source: American Journal of Rhinology and Allergy - March 8, 2017 Category: ENT & OMF Authors: E Chiarella S, Sy H, T Peters A Tags: Am J Rhinol Allergy Source Type: research
Risk of obstructive sleep apnea in African American patients with chronic rhinosinusitis.
CONCLUSION: African American patients with CRS were at higher risk for OSA compared with white patients, and this patient group needs to be screened for OSA.
PMID: 28457643 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - April 27, 2017 Category: Allergy & Immunology Authors: Hui JW, Ong J, Herdegen JJ, Kim H, Codispoti CD, Kalantari V, Tobin MC, Schleimer RP, Batra PS, LoSavio PS, Mahdavinia M Tags: Ann Allergy Asthma Immunol Source Type: research
Immunopathologic characteristics of nasal polyps in adult Koreans: A single-center study.
CONCLUSION: The immunopathologic characteristics differed between eosinophilic NP and noneosinophilic NP and between atopic NP and nonatopic NP. The different underlying pathogenic processes may influence the development of Korean NP.
PMID: 28490401 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - May 1, 2017 Category: ENT & OMF Authors: Shin SH, Kim YH, Ye MK, Choi SY Tags: Am J Rhinol Allergy Source Type: research
Emerging Endotypes of Chronic Rhinosinusitis and Its Application to Precision Medicine.
This article reviews recent publications regarding endotypes and endotype-based therapeutic strategies in CRS and NP.
PMID: 28497916 [PubMed]
Source: Allergy, Asthma and Immunology Research - May 13, 2017 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research
Distribution, subtype population, and IgE positivity of mast cells in chronic rhinosinusitis with nasal polyps.
CONCLUSION: The present study demonstrates that the distribution, subtype population, and IgE positivity of mast cells is different between ECRS and non-ECRS nasal polyps. Our results suggest a role for IgE-mediated mast cell activation in the pathogenesis of ECRS.
PMID: 28634018 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - June 17, 2017 Category: Allergy & Immunology Authors: Baba S, Kondo K, Suzukawa M, Ohta K, Yamasoba T Tags: Ann Allergy Asthma Immunol Source Type: research
Prevalence of polyp recurrence after endoscopic sinus surgery for chronic rhinosinusitis with nasal polyposis.
PMID: 28716181 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - July 1, 2017 Category: ENT & OMF Authors: Amedee RG Tags: Am J Rhinol Allergy Source Type: research
Surgical treatment of chronic rhinosinusitis after sinus lift.
CONCLUSION: Functional endoscopic sinus surgery was a reasonable and efficacious treatment option for patients who presented with paranasal sinus disease after a sinus lift. Dental implant removal may not be a requirement for successful treatment of CRS associated with sinus lift procedures.
PMID: 28716179 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - July 1, 2017 Category: ENT & OMF Authors: Jiam NT, Goldberg AN, Murr AH, Pletcher SD Tags: Am J Rhinol Allergy Source Type: research
The relationship between chronic rhinosinusitis and metabolic syndrome.
CONCLUSION: CRS was more prevalent in patients with metabolic syndrome, especially those with allergic rhinitis, than in patients without metabolic syndrome. Accordingly, CRS should be considered in patients with metabolic syndrome and allergic rhinitis.
PMID: 28716172 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - July 1, 2017 Category: ENT & OMF Authors: Lee EJ, Hwang HJ, Jung CM, Kim MK, Kang MS, Kim KS Tags: Am J Rhinol Allergy Source Type: research
Osteopontin induced vascular endothelial growth factor production in dispersed nasal polyp cells through the phosphatidylinositol 3-kinase-protein kinase B and the extracellular signal-regulated kinase 1/2 pathways.
CONCLUSION: Our findings demonstrated that OPN and VEGF were overproduced in NPs and that OPN induced VEGF production, which indicated that OPN-VEGF axis might contribute to angiogenesis in NPs.
PMID: 28716167 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - July 1, 2017 Category: ENT & OMF Authors: Du J, Mao H, Ouyang H, Xin Y Tags: Am J Rhinol Allergy Source Type: research
Nasal interleukin 25 as a novel biomarker for patients with chronic rhinosinusitis with nasal polyps and airway hypersensitiveness: A pilot study.
CONCLUSION: Our findings indicated that IL-25 was significantly increased in NP tissues and may be considered as the molecular indicator for AHR in patients with CRSwNP.
TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02110654.
PMID: 28870448 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - September 1, 2017 Category: Allergy & Immunology Authors: Chen F, Hong H, Sun Y, Hu X, Zhang J, Xu G, Zhao W, Li H, Shi J Tags: Ann Allergy Asthma Immunol Source Type: research
Role of exhaled nasal nitric oxide in distinguishing between chronic rhinosinusitis with and without nasal polyps.
CONCLUSION: Exhaled nNO levels can be used to distinguish between patients with CRSwNP and patients with CRSsNP. However, the atopic status of the patient influenced the use of nNO as a diagnostic or monitoring biomarker in CRS.
PMID: 28927489 [PubMed - as supplied by publisher]
Source: American Journal of Rhinology and Allergy - September 19, 2017 Category: ENT & OMF Tags: Am J Rhinol Allergy Source Type: research
Expression of immunoglobulin D is increased in chronic rhinosinusitis.
CONCLUSION: IgD plasma cells are prominent in sinus tissues and are increased in CRS. That IgD protein also shows the lowest concentration of antibodies in secretions suggests that its activity might be targeted to the tissue rather than secretions.
PMID: 28958373 [PubMed - in process]
Source: Annals of Allergy, Asthma and Immunology - September 30, 2017 Category: Allergy & Immunology Authors: Sokoya M, Ramakrishnan VR, Frank DN, Rahkola J, Getz A, Kingdom TT, Kofonow JM, Nguyen Q, Janoff EN Tags: Ann Allergy Asthma Immunol Source Type: research
Vitamin D ₃ deficiency and its association with nasal polyposis in patients with cystic fibrosis and patients with chronic rhinosinusitis.
CONCLUSION: VD3 deficiency seemed to be associated with the presence of nasal polyps in the patients with CRS and in the patients with CF in a similar manner. The lower the level of serum VD3, the more severe the mucosal disease was found in the imaging studies and the more frequent microbial colonization of the patients with CF and the patients with CRS.
PMID: 29122084 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - November 1, 2017 Category: ENT & OMF Authors: Konstantinidis I, Fotoulaki M, Iakovou I, Chatziavramidis A, Mpalaris V, Shobat K, Markou K Tags: Am J Rhinol Allergy Source Type: research
Role of adenosine monophosphate-activated protein kinase on cell migration, matrix contraction, and matrix metalloproteinase-1 and matrix metalloproteinase-2 production in nasal polyp-derived fibroblasts.
CONCLUSION: AMPK played an important role in regulating cell migration, matrix contraction, and MMP production in NPDFs, which provided data that AMPK activator might be a therapeutic target for the prevention of tissue remodeling in nasal polyps.
PMID: 29122080 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - November 1, 2017 Category: ENT & OMF Authors: Um JY, Lee SA, Park JH, Shin JM, Park IH, Lee HM Tags: Am J Rhinol Allergy Source Type: research
Sinonasal T-cell expression of cytotoxic mediators granzyme B and perforin is reduced in patients with chronic rhinosinusitis.
CONCLUSION: Total levels of sinonasal GrB and perforin were decreased in the sinonasal mucosa of both the patients with CRSwNP and the patients with CRSsNP compared with the controls, whereas sinonasal CD8+ T cells, (but not NK cells,), intracellular stores of GrB and perforin were reduced in the patients with CRSwNP compared with the controls.
PMID: 29122079 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - November 1, 2017 Category: ENT & OMF Authors: Smith SE, Schlosser RJ, Yawn JR, Mattos JL, Soler ZM, Mulligan JK Tags: Am J Rhinol Allergy Source Type: research
