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Vitamin D Improves the Effect of Glucocorticoids on Attenuating Lipopolysaccharide-Induced IL-6 Production via TLR4/NF- κB Pathway in Human Respiratory Epithelial Cells
Conclusion: Our findings demonstrated that vitamin D could improve the effect of GCs to alleviate the level of IL-6 induced by LPS via the TLR4/NF- κB pathway in human respiratory epithelial cells.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - June 3, 2022 Category: Allergy & Immunology Source Type: research

Vitamin D inhibits TGF- β1-induced myofibroblast differentiation and extracellular matrix production via Smad2/3 signaling pathway in nasal polyp-derived fibroblasts
Nasal polyps are associated with chronic inflammation of the mucous membranes in the nose and paranasal sinuses and involved in extracellular matrix (ECM) accumulation. Vitamin D has a wide range of antifibrotic properties, including anti-inflammation, anti-proliferation, anti-apoptosis, and anti-epithelial-mesenchymal transition properties.
Source: Journal of Allergy and Clinical Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Jae-Min Shin, Hyun-Woo Yang, Seoung Ae Lee, Joo-Hoo Park, Hwee-Jin Kim, Heung Man Lee Source Type: research

Vitamin D ₃ deficiency and its association with nasal polyposis in patients with cystic fibrosis and patients with chronic rhinosinusitis.
CONCLUSION: VD3 deficiency seemed to be associated with the presence of nasal polyps in the patients with CRS and in the patients with CF in a similar manner. The lower the level of serum VD3, the more severe the mucosal disease was found in the imaging studies and the more frequent microbial colonization of the patients with CF and the patients with CRS. PMID: 29122084 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - November 1, 2017 Category: ENT & OMF Authors: Konstantinidis I, Fotoulaki M, Iakovou I, Chatziavramidis A, Mpalaris V, Shobat K, Markou K Tags: Am J Rhinol Allergy Source Type: research