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Serum eosinophil cationic protein: a prognostic factor for early postoperative recurrence of nasal polyps
ConclusionSerum ECP appears to be a feasible predictor for early postoperative recurrence of nasal polyps. CRSwNP patients with preoperative serum ECP levels of ≥21.8 µg/L had an approximately 55‐fold increased risk of early recurrence. CRSwNP patients with higher preoperative serum ECP levels should be closely monitored within the first year after surgery.
Source: International Forum of Allergy and Rhinology - March 23, 2021 Category: Allergy & Immunology Authors: Pin ‐Ching Lu, Ta‐Jen Lee, Chi‐Che Huang, Po‐Huang Chang, Yi‐Wei Chen, Chia‐Hsiang Fu Tags: ORIGINAL ARTICLE Source Type: research

Indirect Treatment Comparison of Biologics in Chronic Rhinosinusitis with Nasal Polyps
Publication date: Available online 4 February 2021Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Anju T. Peters, Joseph K. Han, Peter Hellings, Enrico Heffler, Philippe Gevaert, Claus Bachert, Yingxin Xu, Chien-Chia Chuang, Binod Neupane, Jérôme Msihid, Leda P. Mannent, Patricia Guyot, Siddhesh Kamat
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 4, 2021 Category: Allergy & Immunology Source Type: research

Health-Related Quality of Life Impairment Among Patients With Severe Chronic Rhinosinusitis With Nasal Polyps in the SINUS-24 Trial
Chronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory disease of the nasal cavity and paranasal sinuses, with a high symptom burden and significant impact on health-related quality of life (HRQoL). This analysis compared baseline generic physical and mental HRQoL, and overall health status, of patients with severe CRSwNP on background mometasone furoate from the SINUS-24 (NCT02912468) study, with general population norms.
Source: Journal of Allergy and Clinical Immunology - February 1, 2021 Category: Allergy & Immunology Authors: Jorge Maspero, Carl Philpott, Peter Hellings, Claire Hopkins, Martin Wagenmann, Shahid Siddiqui, Juby Jacob-Nara, Jerome Msihid, Chien-Chia Chuang, Siddhesh Kamat, Asif Khan Source Type: research

A Responder Analysis To Demonstrate Dupilumab Treatment Effect Across Objective and Patient-Reported Subjective Endpoints For Patients with Severe Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)
Dupilumab has demonstrated reduction in nasal polyp score (NPS) and individual symptom scores in patients with severe CRSwNP; however, combined responder analyses using these endpoints have not been conducted. This post hoc analysis explored the overall effect of dupilumab across both objective and patient-reported subjective endpoints.
Source: Journal of Allergy and Clinical Immunology - February 1, 2021 Category: Allergy & Immunology Authors: Claus Bachert, Anju Peters, Enrico Heffler, Joseph Han, Heidi Olze, Oliver Pfaar, Chien-Chia Chuang, Raj Rout, Richa Attre, Ledia Goga, Juby Jacob-Nara, Paul Rowe, Yamo Deniz, Zhen Chen, Siddhesh Kamat, Shahid Siddiqui Source Type: research

Serum eosinophil cationic protein: a prognostic factor for early postoperative recurrence of nasal polyps
ConclusionSerum ECP appears to be a feasible predictor for early postoperative recurrence of nasal polyps. CRSwNP patients with preoperative serum ECP levels of ≥21.8 µg/L had an approximately 55‐fold increased risk of early recurrence. CRSwNP patients with higher preoperative serum ECP levels should be closely monitored within the first year after surgery.
Source: International Forum of Allergy and Rhinology - August 6, 2020 Category: Allergy & Immunology Authors: Pin ‐Ching Lu, Ta‐Jen Lee, Chi‐Che Huang, Po‐Huang Chang, Yi‐Wei Chen, Chia‐Hsiang Fu Tags: ORIGINAL ARTICLE Source Type: research

Asthma onset pattern and patient outcomes in a chronic rhinosinusitis population
ConclusionWhile CRS‐specific and asthma‐specific patient‐reported outcome measures (PROMs) were not significantly different among groups, CRS patients with late‐onset asthma had poorer physical function, more frequent nasal polyposis, and required increased treatment for CRS. Late‐onset asthma may predict more severe disease in CRS.
Source: International Forum of Allergy and Rhinology - December 1, 2017 Category: Allergy & Immunology Authors: Christopher Jones, Caroline P.E. Price, Ava R. Weibman, Kevin C. Welch, David B. Conley, Stephanie Shintani ‐Smith, Whitney W. Stevens, Anju T. Peters, Leslie Grammer, Alcina K. Lidder, Robert P. Schleimer, Robert C. Kern, Bruce K. Tan Tags: ORIGINAL ARTICLE Source Type: research

A paradigm for evaluation and management of the maxillary sinus before dental implantation
ConclusionCraniofacial CT is crucial for pre‐dental implantation sinonasal evaluation. The risk of dental implant‐related chronic rhinosinusitis is low for patients with cysts, polyps, or mucosal thickening in the maxillary sinus. However, preventive endoscopic sinus surgery is recommended for patients with incurable chronic rhinosinusitis, fungal sinusitis, and large polyps or cysts. Level of Evidence4. Laryngoscope, 2017
Source: The Laryngoscope - September 16, 2017 Category: ENT & OMF Authors: Yi ‐Wei Chen, Fu‐Ying Lee, Po‐Hung Chang, Chi‐Che Huang, Chia‐Hsiang Fu, Chien‐Chia Huang, Ta‐Jen Lee Tags: Allergy/Rhinology Source Type: research

Decreased SPLUNC1 expression is associated with Pseudomonas infection in surgically treated chronic rhinosinusitis patients who may require repeated sinus surgery
ConclusionsSinusitis with positive P. aeruginosa bacterial culture is associated with decreased SPLUNC1 sinus mucosa expression. Repeated sinus surgeries are more frequently needed for these patients. Level of Evidence4 Laryngoscope, 2013
Source: The Laryngoscope - January 31, 2013 Category: ENT & OMF Authors: Yung‐An Tsou, Chuan‐Mu Chen, Tzu‐Chieh Lin, Fang‐Wei Hu, Chin‐Jann Tai, Hui‐Chen Chen, Te‐Huei Yeh, Horng‐Jyh Harn, Ming‐Hsui Tsai, Chia‐Ing Jan Tags: Allergy/Rhinology Source Type: research