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Clinical outcomes of dupilumab therapy in chronic rhinosinusitis with nasal polyps in a Canadian tertiary care rhinology practice
In 2020, dupilumab became the first monoclonal antibody therapy to be approved by Health Canada for the treatment of chronic rhinosinusitis with nasal polyps (CRSwNP). The primary aim of this study was to char...
Source: Allergy, Asthma and Clinical Immunology - March 30, 2023 Category: Allergy & Immunology Authors: Elysia Grose, Alyssa Y. Li and John M. Lee Tags: Research Source Type: research

Patient characteristics and treatment of chronic rhinosinusitis with nasal polyps (CRSwNP) in Canada
Conclusions: Medical and surgical management was frequently observed in this large CRSwNP cohort and one third also had asthma. Further data on the rate of recurrence leading to retreatment and associated costs are needed to understand the economic burden of CRSwNP in Canada.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Szabo, S., Gendron, A., Deighton, A., Dragan, R., Detillieux, G., Prior, H., Noorduyn, S. Tags: Allergy and immunology Source Type: research

Loss-of-Function in SMAD4 Might Not Be Critical for Human Natural Killer Cell Responsiveness to TGF- β
This study was carried out in accordance with approval of the Melbourne Health and Walter and Eliza Hall Institute of Medical Research's Human Research Ethics Committee (approval number: 2013.081). All subjects gave written informed consent for participation and publication. Results and Discussion TGF-β signaling in NK cells is associated with: phosphorylation in SMAD2 and 3, inhibition of IL-15-induced metabolism/proliferation, simultaneous downregulation of CD44, CD49e, and Eomes, and upregulation of CD16 and CD49a expression (7, 10). SMAD family member 4 (SMAD4) belongs to the SMAD family of transcript...
Source: Frontiers in Immunology - April 30, 2019 Category: Allergy & Immunology Source Type: research

Canadian guidelines for chronic rhinosinusitis: Clinical summary.
CONCLUSION: The Canadian guidelines provide diagnosis and treatment approaches based on the current understanding of the disease and available evidence. Additionally, the guidelines provide the expert opinion of a diverse group of practice and academic experts to help guide clinicians where evidence is sparse. PMID: 24336538 [PubMed - in process]
Source: Canadian Family Physician Medecin de Famille Canadien - December 1, 2013 Category: Primary Care Authors: Kaplan A Tags: Can Fam Physician Source Type: research