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Association between Staphylococcal Enterotoxin (SE)-specific IgE and specific IgE for house dust mites (HDM) in Brazilian patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP).
SE are a group of superantigens formerly associated with several respiratory diseases, including asthma, rhinitis and CRSwNP. Superantigens trigger the production of high specific IgE levels and are usually related to high levels of total IgE (tIgE) and eosinophilic inflammation.We aim to evaluate the correlation between the positivity of SE-specific IgE for A; B; C; TSST-1; tIgE and specific IgE for D. pteronyssinus (DP); D. farinae (DF) and B. tropicalis (BT) in CRSwNP Brazilian patients.36 CSRwNP patients, defined by 2012-EPOS (European Position Paper on Rhinosinusitis) criteria, submitted to nasal endoscopy and CT...
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Campos Dos Santos, P., Dortas Junior, S., Elabras Filho, J., Da Cruz, F., Valle, S., Ferraiolo, P. Tags: 05.03 - Allergy and immunology Source Type: research

Loss-of-Function in SMAD4 Might Not Be Critical for Human Natural Killer Cell Responsiveness to TGF- β
This study was carried out in accordance with approval of the Melbourne Health and Walter and Eliza Hall Institute of Medical Research's Human Research Ethics Committee (approval number: 2013.081). All subjects gave written informed consent for participation and publication. Results and Discussion TGF-β signaling in NK cells is associated with: phosphorylation in SMAD2 and 3, inhibition of IL-15-induced metabolism/proliferation, simultaneous downregulation of CD44, CD49e, and Eomes, and upregulation of CD16 and CD49a expression (7, 10). SMAD family member 4 (SMAD4) belongs to the SMAD family of transcript...
Source: Frontiers in Immunology - April 30, 2019 Category: Allergy & Immunology Source Type: research

Role of Periostin in Brazilian Patients with Aspirin Exacerbated Respiratory Disease
Aspirin exacerbated respiratory disease (AERD) is characterized by chronic rhinosinusitis with nasal polyps, asthma and hypersensitivity to Aspirin/NSAIDs. Increased levels of periostin have been described in patients with AERD. We evaluated serum periostin in Brazilian patients with AERD, and compared to patients with Perennial Allergic Rhinitis (PAR) and healthy individuals.
Source: Journal of Allergy and Clinical Immunology - February 1, 2019 Category: Allergy & Immunology Authors: Julianne Alves Machado, Daniel L. Cordeiro, Thais Nociti Mendonca, Marcelo Leite, Ricardo Demarco, Ricardo Lessa, Adriana Murashima, Leilane Nogueira, Marina Dias, Adriana S. Moreno, Wilma Lima, Luisa Karla P. Arruda Source Type: research