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Specialty: Psychiatry
Condition: Alzheimer's
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Total 197 results found since Jan 2013.
Mid-Life Proteinuria and Late-Life Cognitive Function and Dementia in Elderly Men: The Honolulu-Asia Aging Study.
CONCLUSION:: Mid-life proteinuria was an independent predictor for late-life incident all-cause dementia and cognitive decline over 8 years.
PMID: 25626635 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - February 1, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
The Influence of Vascular Risk Factors and Stroke on Cognition in Late Life: Analysis of the NACC Cohort.
CONCLUSIONS:: Although the modified Framingham Stroke Risk Profile in late-life predicts rate of decline on selective neurocognitive measures in previously normal elderly individuals, age appears to be the strongest risk factor for cognitive impairment in this population. History of stroke independently influences rate of cognitive decline in these individuals.
PMID: 25626633 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - February 1, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
Carotid plaque as a predictor of dementia in older adults: The Three-City Study.
CONCLUSION: In older adults, CP are independent predictors of incident VaD and may improve VaD risk prediction.
PMID: 25510384 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - December 17, 2014 Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Vascular contributions to cognitive impairment and dementia including Alzheimer's disease.
Authors: Snyder HM, Corriveau RA, Craft S, Faber JE, Greenberg SM, Knopman D, Lamb BT, Montine TJ, Nedergaard M, Schaffer CB, Schneider JA, Wellington C, Wilcock DM, Zipfel GJ, Zlokovic B, Bain LJ, Bosetti F, Galis ZS, Koroshetz W, Carrillo MC
Abstract
Scientific evidence continues to demonstrate the linkage of vascular contributions to cognitive impairment and dementia such as Alzheimer's disease. In December, 2013, the Alzheimer's Association, with scientific input from the National Institute of Neurological Disorders and Stroke and the National Heart, Lung and Blood Institute from the National Institutes of Heal...
Source: The Journal of Alzheimers Association - December 17, 2014 Category: Psychiatry Tags: Alzheimers Dement Source Type: research
The GRK2 Overexpression Is a Primary Hallmark of Mitochondrial Lesions during Early Alzheimer Disease.
Authors: Obrenovich ME, Palacios HH, Gasimov E, Leszek J, Aliev G
Abstract
Increasing evidence points to vascular damage as an early contributor to the development of two leading causes of age-associated dementia, namely Alzheimer disease (AD) and AD-like pathology such as stroke. This review focuses on the role of G protein-coupled receptor kinases (GRKs) as they relate to dementia and how the cardio and cerebrovasculature is involved in AD pathogenesis. The exploration of GRKs in AD pathogenesis may help bridge gaps in our understanding of the heart-brain connection in relation to neurovisceral damage and vascula...
Source: Cardiovascular Psychiatry and Neurology - November 25, 2014 Category: Psychiatry Tags: Cardiovasc Psychiatry Neurol Source Type: research
Targeting S100B in Cerebral Ischemia and in Alzheimer's Disease.
Authors: Mori T, Asano T, Town T
Abstract
S100B is an EF-hand calcium-binding protein that exerts both intracellular and extracellular effects on a variety of cellular processes. The protein is predominantly expressed in the central nervous system by astrocytes, both physiologically and during the course of neurological disease. In the healthy adult brain and during development, constitutive S100B expression acts as a trophic factor to drive neurite extension and to referee neuroplasticity. Yet, when induced during central nervous system disease, the protein can take on maladaptive roles and thereby exacerbate brai...
Source: Cardiovascular Psychiatry and Neurology - November 25, 2014 Category: Psychiatry Tags: Cardiovasc Psychiatry Neurol Source Type: research
Risk of dementia in elderly patients with the use of proton pump inhibitors.
Authors: Haenisch B, von Holt K, Wiese B, Prokein J, Lange C, Ernst A, Brettschneider C, König HH, Werle J, Weyerer S, Luppa M, Riedel-Heller SG, Fuchs A, Pentzek M, Weeg D, Bickel H, Broich K, Jessen F, Maier W, Scherer M
Abstract
Drugs that modify the risk of dementia in the elderly are of potential interest for dementia prevention. Proton pump inhibitors (PPIs) are widely used to reduce gastric acid production, but information on the risk of dementia is lacking. We assessed association between the use of PPIs and the risk of dementia in elderly people. Data were derived from a longitudinal, multicenter cohort s...
Source: European Archives of Psychiatry and Clinical Neuroscience - October 25, 2014 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research
Mid-life Cardiovascular Risk Impacts Memory Function: The Framingham Offspring Study.
CONCLUSIONS:: Middle-aged healthy adults with cardiovascular risk factors including diabetes, history of smoking, and ApoE4 positivity were found to have greater later-life memory impairments.
PMID: 25187219 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - September 5, 2014 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
Atherosclerotic calcification is related to a higher risk of dementia and cognitive decline.
CONCLUSIONS: Atherosclerosis, in particular in the extracranial carotid arteries, is related to a higher risk of dementia and cognitive decline.
PMID: 25150731 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - August 26, 2014 Category: Psychiatry Tags: Alzheimers Dement Source Type: research
A comparison of neuropsychological performance between US and Russia: Preparing for a global clinical trial.
CONCLUSIONS: Sources of variation include cultural differences, health conditions, and exposure to test stimuli. Findings highlight the importance of local norms to interpret test performance.
PMID: 25066497 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - July 31, 2014 Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Aggregate effects of vascular risk factors on cerebrovascular changes in autopsy-confirmed Alzheimer's disease.
We examined the relationships of antemortem vascular risk factors to postmortem cerebrovascular and Alzheimer's disease (AD) pathologies. Eighty-four AD patients underwent an assessment of vascular risk (blood pressure, cholesterol, smoking, cardiovascular disease, diabetes, atrial fibrillation, transient ischemic attack [TIA], or stroke) and later underwent brain autopsy. Given our aim to examine mild cerebrovascular changes (CVCs), individuals were excluded if autopsy revealed large stroke. The most common forms of CVC were circle of Willis atherosclerosis followed by arteriosclerosis, lacunes, and microinfarcts. Excludi...
Source: The Journal of Alzheimers Association - July 17, 2014 Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Alzheimer's Association report.
This report discusses the public health impact of Alzheimer’s disease (AD), including incidence and prevalence, mortality rates, costs of care, and overall effect on caregivers and society. It also examines the impact of AD on women compared with men. An estimated 5.2 million Americans have AD. Approximately 200,000 people younger than 65 years with AD comprise the younger onset AD population; 5 million are age 65 years or older. By mid-century, fueled in large part by the baby boom generation, the number of people living with AD in the United States is projected to grow by about 9 million. Today, someone in the country ...
Source: The Journal of Alzheimers Association - May 13, 2014 Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Midlife stroke risk and cognitive decline.
Authors: Vidale S
PMID: 24721527 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - April 12, 2014 Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Apraxia in Mild Cognitive Impairment and Alzheimer's Disease: Validity and Reliability of the Van Heugten Test for Apraxia.
Conclusion: Apraxia can be reliably measured with the VHA and is present in a proportion of patients with MCI and AD. The presence of apraxia in AD is related to dementia severity and APOE ε4. © 2014 S. Karger AG, Basel.
PMID: 24603451 [PubMed - as supplied by publisher]
Source: Dementia and Geriatric Cognitive Disorders - March 10, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
Risk factors for incident dementia after stroke and transient ischemic attack.
CONCLUSIONS: Chronic brain changes including WMCs, MTLA, and AD pathology are associated with incident dementia after stroke/TIA. Interventions targeting these chronic brain changes may reduce burden of vascular cognitive impairment.
PMID: 24603162 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - March 10, 2014 Category: Psychiatry Tags: Alzheimers Dement Source Type: research
