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Capsaicin, The Vanilloid Receptor TRPV1 Agonist in Neuroprotection: Mechanisms Involved and Significance
Neurochem Res. 2023 Jul 26. doi: 10.1007/s11064-023-03983-z. Online ahead of print.ABSTRACTHot peppers, also called chilli, chilli pepper, or paprika of the plant genus Capsicum (family Solanaceae), are one of the most used vegetables and spices worldwide. Capsaicin (8-methyl N-vanillyl-6-noneamide) is the main pungent principle of hot green and red peppers. By acting on the capsaicin receptor or transient receptor potential cation channel vanilloid subfamily member 1 (TRPV1), capsaicin selectively stimulates and in high doses defunctionalizes capsaicin-sensitive chemonociceptors with C and Aδ afferent fibers. This channe...
Source: Neurochemical Research - July 26, 2023 Category: Neuroscience Authors: Omar M E Abdel-Salam Gyula M ózsik Source Type: research

Molecules, Vol. 27, Pages 2484: Beneficial Effects of Capsaicin in Disorders of the Central Nervous System
k Capsaicin is a natural compound found in chili peppers and is used in the diet of many countries. The important mechanism of action of capsaicin is its influence on TRPV1 channels in nociceptive sensory neurons. Furthermore, the beneficial effects of capsaicin in cardiovascular and oncological disorders have been described. Many recent publications show the positive effects of capsaicin in animal models of brain disorders. In Alzheimer’s disease, capsaicin reduces neurodegeneration and memory impairment. The beneficial effects of capsaicin in Parkinson’s disease and depression have also be...
Source: Molecules - April 12, 2022 Category: Chemistry Authors: Micha ł Pasierski Bart łomiej Szulczyk Tags: Review Source Type: research

Oversleeping: The Effects and Health Risks of Sleeping Too Much
This article originally appeared on the Amerisleep blog. Rosie Osmun is the Creative Content Manager at Amerisleep, a progressive memory foam mattress brand focused on eco-friendly sleep solutions. Rosie writes more posts on the Amerisleep blog about the science of sleep, eco-friendly living, leading a healthy lifestyle and more. -- This feed and its contents are the property of The Huffington Post, and use is subject to our terms. It may be used for personal consumption, but may not be distributed on a website.
Source: Healthy Living - The Huffington Post - January 29, 2016 Category: Consumer Health News Source Type: news

New brain diet 'slows mental decline'
ConclusionThis observational study aimed to investigate the relationship between the MIND diet and its protective properties for mental decline in an older population. The study has several strengths, including the large sample size, long observational period of up to nine years, regular annual assessment of cognitive functions, and comprehensive assessment of diet. However, one of the main limitations is that this type of study cannot show cause and effect – it can only show an association between the diet and slower mental decline. There may be other unmeasured factors that account for the results, such as genetics, ...
Source: NHS News Feed - August 6, 2015 Category: Consumer Health News Tags: Food/diet Neurology Source Type: news

The Most Promising Cancer-Fighter In Years
For a while now, I’ve been recommending a powerful antioxidant with the unpronounceable name, pyrroloquinoline quinine – or PQQ for short. And although I recommend this compound to almost everyone who comes to see me at my wellness clinic in South Florida because of its energy-giving qualities, I’ve also observed its extraordinary power to fight cancer. For years, I’ve seen PQQ work wonders with my older patients, because it keeps you feeling young by giving your cells extra energy. PQQ was first discovered back in 1979 by a team of Japanese scientists, who knew little about the substance, except that i...
Source: Al Sears, MD Natural Remedies - March 24, 2015 Category: Complementary Medicine Authors: Andrew Britton Tags: Anti-Aging antioxidants Cancer energy Source Type: news

You're Eating Fish All Wrong
By Cynthia Sass, MPH, RD Eating fish has been tied with lower rates of heart disease, stroke, depression and Alzheimer's disease. But how you eat it may be the real key to reaping its benefits. Recent research from University of Pittsburgh School of Medicine concluded that study volunteers who regularly ate fish had larger brain volumes in regions associated with memory and cognition, but only if the fish baked or broiled, not fried. Baking and broiling are also better for your waistline. For example, a dozen fried shrimp can pack 280 calories, versus a mere 85 calories for 12 shrimp that have been steamed or broiled. To...
Source: Healthy Living - The Huffington Post - November 2, 2014 Category: Consumer Health News Source Type: news