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Modulation of vulvovaginal atrophy (VVA) by Gelam honey in bilateral oophorectomized rats
In conclusion, the protein and gene expression changes in the vagina by Gelam honey had reduced the occurrence of vaginal atrophy in surgically-induced menopause models.
Source: Frontiers in Endocrinology - February 27, 2023 Category: Endocrinology Source Type: research

When hormonal treatment is not an option
An integrated analysis of safety data from seven Phase 2/3 double-blind, placebo-controlled trials has been conducted for ospemifene (Senshio ®). Adverse drug reactions are well characterized, benign and not unexpected from a SERM used for the treatment of VVA (i.e. hot flushes, leg cramps). There is no evidence to date that ospemifene leads to an increase in vaginal bleeding, endometrial hyperplasia or cancer; VTE, stroke or other cardi ovascular events; or any other adverse event of special interest.
Source: Maturitas - February 14, 2018 Category: Primary Care Authors: Felix Lugo Source Type: research

The evolving role of oral hormonal therapies and review of conjugated estrogens/bazedoxifene for the management of menopausal symptoms.
Authors: Parish SJ, Gillespie JA Abstract This review describes the evolving role of oral hormone therapy (HT) for treating menopausal symptoms and preventing osteoporosis, focusing on conjugated estrogens/bazedoxifene (CE/BZA). Estrogens alleviate hot flushes and prevent bone loss associated with menopause. In nonhysterectomized women, a progestin should be added to estrogens to reduce the risk of endometrial cancer. Use of HT declined since the Women's Health Initiative (WHI) studies showed that HT does not prevent coronary heart disease (CHD) and that conjugated estrogens/medroxyprogesterone acetate increased th...
Source: Postgraduate Medicine - February 1, 2017 Category: Internal Medicine Tags: Postgrad Med Source Type: research

Bioidentical hormones for women with vasomotor symptoms.
CONCLUSIONS: There was low to moderate quality evidence that BHT in various forms and doses is more effective than placebo for treating moderate to severe menopausal hot flushes. There was low to moderate quality evidence of higher rates of adverse effects such as headache, vaginal bleeding, breast tenderness and skin reactions in the BHT group. There was some evidence to suggest that higher doses of BHT are associated with greater effectiveness but also with higher risk of adverse effects. Although all the included studies used unopposed estrogen, it is recommended best practice to use progestogen therapy in women with a ...
Source: Cochrane Database of Systematic Reviews - July 31, 2016 Category: Journals (General) Authors: Gaudard AM, Silva de Souza S, Puga ME, Marjoribanks J, da Silva EM, Torloni MR Tags: Cochrane Database Syst Rev Source Type: research

Diagnosis of an aortic valvular lesion
From the question on page 719 Clinical introduction A 59-year-old woman with hypertension presented with right-sided weakness and vision loss. Her vital signs were normal; cardiopulmonary exam was significant for a systolic and diastolic murmur. MRI of the brain showed multiple chronic bilateral infarctions, and Doppler ultrasound revealed acute left lower extremity deep vein thrombosis. Transthoracic echocardiography (TTE) to determine cardioembolic source of stroke was significant only for severe aortic valve regurgitation. To assess for cardiac vegetations, transoesophageal echocardiography (TEE) was performed (figure 1...
Source: Heart - April 9, 2015 Category: Cardiology Authors: Elboudwarej, O., Wei, J., Siegel, R. Tags: Drugs: cardiovascular system, Echocardiography, Image challenges, Hypertension, Venous thromboembolism, Aortic valve disease, Clinical diagnostic tests Source Type: research