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Exploring beamline momentum acceptance for tracking respiratory variability in lung cancer proton therapy: a simulation study
Phys Med Biol. 2023 Aug 31. doi: 10.1088/1361-6560/acf5c4. Online ahead of print.ABSTRACTObjective
Investigating the aspects of proton beam delivery to track organ motion with pencil beam scanning therapy. Considering current systems as a reference, specify requirements for next-generation units aiming at real-time image-guided treatments. 
Approach
Proton treatments for six non-small cell lung cancer (NSCLC) patients were simulated using repeated 4DCTs to model respiratory motion variability. Energy corrections required for this treatment site were evaluated for different approaches to tumour track...
Source: Physics in Medicine and Biology - August 31, 2023 Category: Physics Authors: Anna Chiara Giovannelli Andreas K öthe Sairos Safai David Meer Ye Zhang Damien Charles Weber Antony John Lomax Giovanni Fattori Source Type: research

Investigation on the proton range uncertainty with spectral CT-based virtual monoenergetic images
CONCLUSIONS: This work presents a way to determine the optimal energy pairs for each organ and to calculate the dose distribution based on the more accurate SPR prediction.PMID:37312288 | DOI:10.1002/acm2.14062
Source: Clinical Lung Cancer - June 14, 2023 Category: Cancer & Oncology Authors: Libing Zhu Yi Du Yahui Peng Xincheng Xiang Xiangang Wang Source Type: research

Independent Association of Metabolic Tumor Response on FDG-PET with Pulmonary Toxicity Following Risk-Adaptive Chemoradiation for Unresectable Non-Small Cell Lung Cancer: Inherent Radiosensitivity or Immune Response?
CONCLUSION: Tumor metabolic response as measured by mean SUV is associated with increased pneumonitis risk in a clinical trial cohort of NSCLC patients independent of treatment factors. This may be partially attributed to patient-specific differences in immunogenicity.PMID:37244360 | DOI:10.1016/j.radonc.2023.109720
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 27, 2023 Category: Radiology Authors: Evan D H Gates Daniel S Hippe Hubert J Vesselle Jing Zeng Stephen R Bowen Source Type: research

Combinatorial approach of immuno-proton therapy in cancer: Rationale and potential impact
Asia Pac J Clin Oncol. 2023 May 16. doi: 10.1111/ajco.13966. Online ahead of print.ABSTRACTCancer management is an expansive, growing, and evolving field. In the last decade or so, immunotherapy (IT) and particle beam therapy have made a tremendous impact in this domain. IT has already established itself as the fourth pillar of oncology. Recent emphasis has been centred around combination therapy, postulating additive or multiplicative effects of combining IT with one or more of the three conventional "pillars," that is, surgery, chemotherapy, and radiotherapy. Radio-IT is being increasingly explored and has shown promisin...
Source: Clinical Lung Cancer - May 17, 2023 Category: Cancer & Oncology Authors: Utpal Gaikwad Jyoti Bajpai Rakesh Jalali Source Type: research

Effect of extended field-of-view approaches on the accuracy of stopping power ratio estimation for single-energy computed tomography simulators
CONCLUSIONS: When an eFOV method is used, the SPR variation in phantoms considerably increases for all TEM rods, especially for lung TEM rods. This phenomenon may substantially increase the uncertainty of HU-to-SPR conversion. Therefore, image reconstruction with a standard FOV size is recommended.PMID:37170691 | DOI:10.1002/acm2.14010
Source: Clinical Lung Cancer - May 12, 2023 Category: Cancer & Oncology Authors: Chang-Shiun Lin Yi-Chun Tsai Liang-Hsin Chen Chun-Wei Wang Chia-Jung Wu Wan-Yu Chen Hsiang-Kung Liang Sung-Hsin Kuo Source Type: research

Clinical results of proton beam radiotherapy for inoperable stage III non-small cell lung cancer: a Japanese national registry study
This study presents the first data of a Japanese nationwide multi-institutional cohort and compares them with the findings of systematic literature reviews on radiation therapies and inoperable stage III non-small cell lung cancer (NSCLC) conducted by the Lung Cancer Working Group in the Particle Beam Therapy (PBT) Committee and Subcommittee at Japanese Society for Radiation Oncology. The Lung Cancer Working Group extracted eight reports and compared their data with those of the PBT registry from May 2016 to June 2018. All the analyzed 75 patients aged ≤80 years underwent proton therapy (PT) with concurrent chemotherapy ...
Source: Cell Research - May 3, 2023 Category: Cytology Authors: Hitoshi Tatebe Hideyuki Harada Keita Mori Hiromitsu Iwata Tetsuo Akimoto Masao Murakami Takahiro Waki Takashi Ogino Masatoshi Nakamura Hiroshi Taguchi Haruhiko Nakayama Miyako Satouchi Hidefumi Aoyama Source Type: research

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