Filtered By:
Cancer: Lung Cancer
Therapy: Cancer Therapy
This page shows you your search results in order of date.
Order by Relevance | Date
Total 727 results found since Jan 2013.
A randomized trial to evaluate the preventive effect of lafutidine on chemotherapy-induced peripheral neuropathy in patients treated with carboplatin and paclitaxel for lung cancer
CONCLUSIONS: Although the preventive effect of lafutidine on CIPN could not be demonstrated statistically, lafutidine FACT/GOG-Ntx scores showed a trend toward decreased neurotoxicity as chemotherapy proceeded. More reliable studies using lafutidine on the prevention of CIPN should be conducted.TRIAL REGISTRATION: Japan Registry of Clinical Trials identifier: jRCTs021200031.PMID:37731302 | DOI:10.21037/apm-23-90
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Katsuya Cho Hirotaka Saikawa Tatsuya Hashimoto Hiroshi Katagiri Yoshihiro Owada Kazuhiro Yakuwa Itaru Fujimura Yu Utsumi Masachika Akiyama Hiromi Nagashima Fumiaki Takahashi Makoto Maemondo Source Type: research
Therapeutic effects of medicinal plants and their constituents on lung cancer, in vitro, in vivo and clinical evidence
J Cell Mol Med. 2023 Sep 12. doi: 10.1111/jcmm.17936. Online ahead of print.ABSTRACTThe most common type of cancer in the world is lung cancer. Traditional treatments have an important role in cancer therapy. In the present review, the most recent findings on the effects of medicinal plants and their constituents or natural products (NP) in treating lung cancer are discussed. Empirical studies until the end of March 2022 were searched using the appropriate keywords through the databases PubMed, Science Direct and Scopus. The extracts and essential oils tested were all shown to effect lung cancer by several mechanisms inclu...
Source: Molecular Medicine - September 12, 2023 Category: Molecular Biology Authors: Arghavan Memarzia Saeideh Saadat Fereshteh Asgharzadeh Sepide Behrouz Gert Folkerts Mohammad Hossein Boskabady Source Type: research
Geographic Disparity of Outcome in Patients With Cancer Over Decades: The Surveillance, Epidemiology, and End Results
CONCLUSIONS: Significant disparities in cancer care exist among geographic locations. Geographic differences in survival appear more prominent when highly effective therapies are available.PMID:37690903 | DOI:10.1016/j.clml.2023.08.001
Source: Clinical Lymphoma and Myeloma - September 10, 2023 Category: Cancer & Oncology Authors: Koji Sasaki Kiyomi Morita Hagop Kantarjian Guillermo Garcia-Manero Elias Jabbour Farhad Ravandi Marina Konopleva Gautam Borthakur William Wierda Naval Daver Koichi Takahashi Courtney DiNardo Guillermo Montalban Bravo Ghayas C Issa Sherry A Pierce Kelly A Source Type: research
Iron oxide nanoparticles induce ferroptosis via the autophagic pathway by synergistic bundling with paclitaxel
Mol Med Rep. 2023 Oct;28(4):198. doi: 10.3892/mmr.2023.13085. Epub 2023 Sep 8.ABSTRACTIn recent years, inhibiting tumor cell activity by triggering cell ferroptosis has become a research hotspot. The development of generic targeted nanotherapeutics might bring new ideas for non‑invasive applications. Currently, the potential mechanism underlying the universal application of paclitaxel (PTX)‑loaded iron oxide nanoparticles (IONP@PTX) to different types of tumors is unclear. The present study aimed to prepare IONP@PTX for targeted cancer therapy and further explore the potential mechanisms underlying the inhibitory effec...
Source: Molecular Medicine - September 8, 2023 Category: Molecular Biology Authors: Qi Nie Wenqing Chen Tianmei Zhang Shangrong Ye Zhongyu Ren Peng Zhang Jian Wen Source Type: research
Selective degradation of BRD4 suppresses lung cancer cell proliferation using GSH-responsive PROTAC precursors
Bioorg Chem. 2023 Sep 3;140:106793. doi: 10.1016/j.bioorg.2023.106793. Online ahead of print.ABSTRACTBRD4,as a transcriptional and epigenetic regulator to mediate cellular functions, plays an important role in cancer development.Targeting BRD4 with conventional inhibitors in cancer therapy requires high doses, which often leads to off-target and adverse effects. BRD4-targeted proteolysis-targeting chimeras (PROTACs) can catalytically degrade BRD4 utilizing the endogenous proteasome system, and exhibit promising anti-tumor activity. However, most of the developed PROTACs are non-cancer specific and relatively toxic towards ...
Source: Bioorganic Chemistry - September 8, 2023 Category: Chemistry Authors: Heli Fan Zhili Zhou Dehao Yu Jing Sun Luo Wang Yuanyuan Jia Junyu Tian Wenyi Mi Huabing Sun Source Type: research
Nicotinic acetylcholine receptors in cancer: Limitations and prospects
Biochim Biophys Acta Mol Basis Dis. 2023 Sep 4:166875. doi: 10.1016/j.bbadis.2023.166875. Online ahead of print.ABSTRACTNicotinic acetylcholine receptors (nAChRs) have long been considered to solely mediate neurotransmission. However, their widespread distribution in the human body suggests a more diverse physiological role. Additionally, the expression of nAChRs is increased in certain cancers, such as lung cancer, and has been associated with cell proliferation, epithelial-to-mesenchymal cell transition, angiogenesis and apoptosis prevention. Several compounds that interact with these receptors have been identified as po...
Source: Biochimica et Biophysica Acta - September 6, 2023 Category: Biochemistry Authors: T Bele T Turk I Kri žaj Source Type: research
A new biphenanthrene with cytotoxic activity from < em > Liparis nervosa < /em > (Thunb.) Lindl
Nat Prod Res. 2023 Sep 3:1-7. doi: 10.1080/14786419.2023.2233670. Online ahead of print.ABSTRACT2,7,2'-Trihydroxy-3,4,4'7'-tetramethoxy-1,1'-biphenanthrene (1), a previously undescribed biphenanthrene, and five known phenanthrenes, i.e. 2,5-dihydroxy-4-methoxy-9,10-dihydroxyphenanthrene (2), 2,4-dihydroxy -7-methoxy-9,10-dihydroxyphenanthrene (3), 7-hydroxy-2-methoxy-phenanthrene-1,4-dione (4), 7-hydroxy-2-methoxy-9,10-dihydro-phenanthrene-1,4-dione (5), and 4,4',7,7'-tetrahydroxy-2,2'-dimethoxy-9,9',10,10'-tetrahydro-1,1'-biphenanthrene (6) were isolated from the whole plant (stems, leaves, roots and fruits) of Liparis ne...
Source: Natural Product Research - September 4, 2023 Category: Biochemistry Authors: Liang Liu Qi-Meng Yin Qi-Jun Dai Xuan-Yuan Chen Xi-Qing Chen Jian-Bin Wang Han-Qing Pang Xian-Wen Zhang Source Type: research
