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Specialty: Cancer & Oncology
Cancer: Lung Cancer
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Total 651 results found since Jan 2013.
Integrin α5 promotes migration and invasion through the FAK/STAT3/AKT signaling pathway in icotinib-resistant non-small cell lung cancer cells
Oncol Lett. 2021 Jul;22(1):556. doi: 10.3892/ol.2021.12817. Epub 2021 May 24.ABSTRACTPatients with non-small cell lung cancer (NSCLC) treated with EGFR-tyrosine kinase inhibitors (TKIs) ultimately develop drug resistance and metastasis. Therefore, there is a need to identify the underlying mechanisms of resistance to EGFR-TKIs. In the present study, colony formation and MTT assays were performed to investigate cell viability following treatment with icotinib. Gene Expression Omnibus datasets were used to identify genes associated with resistance. Wound healing and Transwell assays were used to detect cell migration and inv...
Source: Oncology Letters - June 4, 2021 Category: Cancer & Oncology Authors: Yang Yang Yizhe Wang Xiaofang Che Kezuo Hou Jie Wu Chunlei Zheng Yang Cheng Yunpeng Liu Xuejun Hu Jingdong Zhang Source Type: research
CDK-associated Cullin 1 promotes Cell Proliferation and inhibits Cell Apoptosis in Human Glioblastoma
CONCLUSION: CACUL1 can promote cell proliferation and suppress apoptosis of glioma cells and might serve as a potential oncogene for gliomas.PMID:34080964 | DOI:10.2174/1568009621666210602164225
Source: Current Cancer Drug Targets - June 3, 2021 Category: Cancer & Oncology Authors: Xiaohua Zhang Tianying Zhang Xiaojuan Han Zhongying Qiu Jianghong Cheng Xingchun Gao Xingchun Gou Source Type: research
LncRNA SNHG3 Promotes Proliferation and Metastasis of Non-Small-Cell Lung Cancer Cells Through miR-515-5p/SUMO2 Axis
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211019376. doi: 10.1177/15330338211019376.ABSTRACTLung cancer is a global disease and a major cause of cancer-related mortality worldwide. Accumulated studies have confirmed the essential role of long non-coding RNAs (lncRNAs) in the occurrence and development of cancers. Meanwhile, there have been reports concerning the role of Small Nucleolar RNA Host Gene 3 (SNHG3) in various cancers. However, there are so far few studies on the function and mechanism of SNHG3 in lung cancer. In the present study, SNHG3 was found to be highly expressed in lung cancer tissues and cells. D...
Source: Technology in Cancer Research and Treatment - May 25, 2021 Category: Cancer & Oncology Authors: Yongqun Li Lipin Gao Caiyun Zhang Jiguang Meng Source Type: research
Tripartite motif protein 11 (TRIM11), an oncogene for human lung cancer via the DUSP6-mediated ERK1/2 signaling pathway
In conclusion, TRIM11 is an oncogene in NSCLC, likely through the DUSP6-mediated ERK1/2 signaling pathway.PMID:33970779 | DOI:10.1080/15384047.2021.1902912
Source: Cancer Biology and Therapy - May 10, 2021 Category: Cancer & Oncology Authors: Xiao-Lin Wang Shi-Chun Lu Chao Sun Wei-Guo Jin Yi-Wei Fan Yu-Sheng Shu Hong-Can Shi Ling-Feng Min Source Type: research
EHF enhances malignancy by modulating AKT and MAPK/ERK signaling in non ‑small cell lung cancer cells
Oncol Rep. 2021 Jun;45(6):102. doi: 10.3892/or.2021.8053. Epub 2021 Apr 28.ABSTRACTOverexpression of ETS‑homologous factor (EHF) in non‑small cell lung cancer (NSCLC) is associated with poor patient prognosis. To explore the mechanism of the effect of EHF in NSCLC, EHF expression was examined in NSCLC and its role in cell proliferation, invasion, cell cycle, and apoptosis of NSCLC cells was evaluated by overexpressing EHF and/or knocking down EHF expression in NSCLC cells in vitro and in cancer cell grafted mice in vivo. The results revealed that the knockdown of EHF expression in NSCLC with siRNA significantly inhibit...
Source: Oncology Reports - April 28, 2021 Category: Cancer & Oncology Authors: Lei Gao Tian Yang Shuo Zhang Yiqian Liang Puyu Shi Hui Ren Peng Hou Mingwei Chen Source Type: research
