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Expressions of CD44, PCNA and MRP1 in lung cancer tissues and their effects on proliferation and invasion abilities of lung cancer cell line 95D
CONCLUSION: CD44, PCNA and MRP1, which may be involved in the regulation of the proliferation and invasion abilities of lung cancer cells, may serve as new molecular targeting markers for the diagnosis and treatment of lung cancer.PMID:33721434
Source: Journal of B.U.ON. - March 15, 2021 Category: Cancer & Oncology Authors: Xudong Chen Jinlin Sun Yansen Wang Source Type: research

Quercetin induces pro ‐apoptotic autophagy via SIRT1/AMPK signaling pathway in human lung cancer cell lines A549 and H1299 in vitro
ConclusionsQuercetin ‐induced autophagy contributes to apoptosis in A549 and H1299 lung cancer cells, which involved the SIRT1/AMPK signaling pathway.
Source: Thoracic Cancer - March 12, 2021 Category: Cancer & Oncology Authors: Hengjuan Guo, Hui Ding, Xin Tang, Maoli Liang, Shuo Li, Jing Zhang, Jie Cao Tags: ORIGINAL ARTICLE Source Type: research

Cancers, Vol. 13, Pages 1187: Molecular Signature of Small Cell Lung Cancer after Treatment Failure: The MCM Complex as Therapeutic Target
In this study, we identified a gene expression signature of SCLC after treatment failure using SCLC clinical specimens (GEO accession number: GSE162102). A total of 1,136 genes were significantly upregulated in SCLC tissues. These upregulated genes were subjected to KEGG pathway analysis, and “cell cycle”, “Fanconi anemia”, “alcoholism”, “systemic lupus erythematosus”, “oocyte meiosis”, “homologous recombination”, “DNA replication”, and “p53 signaling” were identified as the enriched pathways among the genes. We focused on the cell cycle pathway and investigated the clinical significance of ...
Source: Cancers - March 10, 2021 Category: Cancer & Oncology Authors: Shunsuke Misono Keiko Mizuno Takayuki Suetsugu Kengo Tanigawa Nijiro Nohata Akifumi Uchida Hiroki Sanada Reona Okada Shogo Moriya Hiromasa Inoue Naohiko Seki Tags: Article Source Type: research

Cancers, Vol. 13, Pages 1021: TRAF4/6 Is Needed for CD44 Cleavage and Migration via RAC1 Activation
We report that CD44 cleavage in A549 lung cancer cells and other cells is promoted by transforming growth factor-beta (TGFβ) in a manner that is dependent on ubiquitin ligase tumor necrosis factor receptor-associated factor 4 or 6 (TRAF4 or TRAF6, respectively). Stem-like A549 cells grown in spheres displayed increased TRAF4-dependent expression of CD44 variant isoforms, CD44 cleavage, and hyaluronan synthesis. Mechanistically, TRAF4 activated the small GTPase RAC1. CD44-dependent migration of A549 cells was inhibited by siRNA-mediated knockdown of TRAF4, which was rescued by the transfection of a constitutively active RA...
Source: Cancers - March 1, 2021 Category: Cancer & Oncology Authors: Constantinos Kolliopoulos Athanasios Chatzopoulos Spyros S. Skandalis Carl-Henrik Heldin Paraskevi Heldin Tags: Article Source Type: research

Cancers, Vol. 13, Pages 1010: EPHA2 Interacts with DNA-PKcs in Cell Nucleus and Controls Ionizing Radiation Responses in Non-Small Cell Lung Cancer Cells
a Viktorsson Ephrin (EFN)/ Erythropoietin-producing human hepatocellular receptors (Eph) signaling has earlier been reported to regulate non-small cell lung cancer (NSCLC) cell survival and cell death as well as invasion and migration. Here, the role of Ephrin type-A receptor 2 (EphA2) on the DNA damage response (DDR) signaling and ionizing radiation (IR) cellular effect was studied in NSCLC cells. Silencing of EphA2 resulted in IR sensitization, with increased activation of caspase-3, PARP-1 cleavage and reduced clonogenic survival. Profiling of EphA2 expression in a NSCLC cell line panel showed a correlation to an IR...
Source: Cancers - February 28, 2021 Category: Cancer & Oncology Authors: Vitaliy O. Kaminskyy Petra H ååg Metka Novak Ákos Végvári Vasiliki Arapi Rolf Lewensohn Kristina Viktorsson Tags: Article Source Type: research

Effects of Cullin1 on the Biological Characteristics of Lung Adenocarcinoma 
A549 and H1395 Cells
Background and objective Cullin1 is a representative member of the Cullin family, and it plays an important role in the ubiquitination of cell cycle, transcription and signal transduction related proteins. Cullin1 is closely related to the occurrence and development of a variety of malignant tumors. The aim of this study is to investigate the effects of Cullin1 on biological function of lung adenocarcinoma A549 and H1395 Cells. Methods The expression of Cullin1 mRNA was detected by quantitative Real-time polymerase chain reaction in lung adenocarcinoma cells (A549, H358, H1395, H1650) and human normal lung epithelial cells...
Source: Chinese Journal of Lung Cancer - February 24, 2021 Category: Cancer & Oncology Source Type: research

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