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Current state of knowledge on immunotherapy in ECOG PS 2 patients. A systematic review
CONCLUSIONS: Immunotherapy seems to be justified in PS 2 patients with NSCLC. This method of treatment has been proven to be safe and tolerable. However, outcomes in this population remain suboptimal and the impact of immunotherapy in this cohort is less dramatic. Multiple scales evaluating many factors beyond PS scores have been suggested to help stratify the PS 2 to reinforce the chance of achieving better treatment outcomes. Randomized trials are needed to determine the benefits of immune checkpoint inhibitors (ICIs) for patients with poor ECOG PS.PMID:34315013 | DOI:10.1016/j.advms.2021.07.005
Source: Advances in Medical Sciences - July 27, 2021 Category: Biomedical Science Authors: Damian Mojsak Beata Kukli ńska Łukasz Minarowski Robert Marek Mr óz Source Type: research

Research on occupational diseases in the absence of occupational data: a mixed-method study among cancer registries of Western Switzerland
Swiss Med Wkly. 2022 Feb 22;152:w30127. doi: 10.4414/smw.2022.w30127. eCollection 2022 Feb 14.ABSTRACTThe contribution of occupation-related diseases to the global burden of disease is greatly underestimated, mainly due to a shortage of occupational exposure data. This problem is particularly salient in Switzerland, where no estimates of occupation-related disease burden exist, even for the well-recognised occupational cancers, such as malignant pleural mesothelioma and lung cancer. To overcome this situation, we launched a research project "Examining Cancers and Labour Indicators to assess the Burden" (ExCaLIBur). Within ...
Source: Swiss Medical Weekly - February 24, 2022 Category: General Medicine Authors: Ekaterina Plys Nicolas Bovio Patrick Arveux Yvan Bergeron Jean-Luc Bulliard Nadia Elia Evelyne Fournier Isabelle Konzelmann Manuela Maspoli Elisabetta Rapiti Aylward Irina Guseva Canu Source Type: research

Observation on the Effect of High-Quality Nursing Intervention plus Health Education in Chemotherapy for Non-Small Cell Lung Cancer and Its Influence on the Physical and Mental Health of Patients
CONCLUSION: The application of high-quality nursing intervention combined with health education in chemotherapy for non-small cell lung cancer has favorable clinical benefits, enhances patient compliance and self-management capacity, and exerts a positive influence on the patient's physical and mental health. Adverse reactions can provide a more trustworthy scientific basis for therapeutic therapy. The method should be widely used.PMID:36034943 | PMC:PMC9410779 | DOI:10.1155/2022/2459013
Source: Cancer Control - August 29, 2022 Category: Cancer & Oncology Authors: Liyun Feng Dongmei Yang Source Type: research

Simultaneous occurrence of coronary artery disease and lung cancer: what is the best surgical treatment strategy?
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was whether combined surgical procedures in one or two stages are the best surgical treatment strategy in patients with simultaneous coronary artery disease and lung cancer. Altogether, 264 papers were found using the reported search; of which, 15 represented the best evidence to answer the clinical question. The authors, journal, date, country of publication, patient group, study type, outcomes and results of papers are tabulated. The outcomes of the reported studies provided interesting results. All the studies...
Source: Interactive CardioVascular and Thoracic Surgery - September 17, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Tourmousoglou, C. E., Apostolakis, E., Dougenis, D. Tags: Education ADULT CARDIAC Source Type: research

Mitral valve repair of isolated posterior leaflet prolapse: resect or respect?
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was whether it is best in a patient with posterior leaflet prolapse to resect tissue from the posterior leaflet or to preserve the leaflet tissue by only adding neochordal reconstruction. Altogether, 279 papers were found using the reported search, of which 16 represented the best evidence to answer the clinical question. The authors, journal, date, country of publication, patient group, study type, relevant outcomes and results of these papers are tabulated. The results of the reported studies provided interesti...
Source: Interactive CardioVascular and Thoracic Surgery - November 22, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Tourmousoglou, C., Lalos, S., Dougenis, D. Tags: Lung - cancer, Cardiac - physiology, Education, Molecular biology, Valve disease, Esophagus - cancer Adult Cardiac Source Type: research

Five-year 'death test' for older adults launched online
Conclusion This large study has identified numerous risk factors associated with a person's risk of death within five years. Researchers used this information to develop an online tool that predicts someone's risk of death within the next five years. The study's strengths include its large sample size and the prospective nature of the study design. But there are some limitations. There may be some bias in the type of people who volunteered to take part. The death rate was lower than that of the average population in this age group, which may indicate that the participants were more interested in their health and so had he...
Source: NHS News Feed - June 4, 2015 Category: Consumer Health News Tags: Heart/lungs Cancer Lifestyle/exercise Medical practice Source Type: news

Impact of Continuing First-Line EGFR Tyrosine Kinase Inhibitor Therapy Beyond RECIST Disease Progression in Patients with Advanced EGFR-Mutated Non-Small-Cell Lung Cancer (NSCLC): Retrospective GFPC 04-13 Study
This study suggests that under certain circumstances, first-line TKI treatment continuation after RECIST progression is an acceptable option in EGFR-mutated NSCLC patients. Clinical trial information: NCT02293733
Source: Targeted Oncology - August 29, 2015 Category: Cancer & Oncology Source Type: research

Diagnosis of Brain Metastases from Lung Cancer Using a Modified Electromagnetism like Mechanism Algorithm
Abstract Brain metastases are commonly found in patients that are diagnosed with primary malignancy on their lung. Lung cancer patients with brain metastasis tend to have a poor survivability, which is less than 6 months in median. Therefore, an early and effective detection system for such disease is needed to help prolong the patients’ survivability and improved their quality of life. A modified electromagnetism-like mechanism (EM) algorithm, MEM-SVM, is proposed by combining EM algorithm with support vector machine (SVM) as the classifier and opposite sign test (OST) as the local search technique. The propo...
Source: Journal of Medical Systems - November 14, 2015 Category: Information Technology Source Type: research