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Cancer: Hepatocellular Carcinoma
Therapy: Gene Therapy
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Total 49 results found since Jan 2013.
Stimuli-Responsive Hydrogel Microcapsules Harnessing the COVID-19 Immune Response for Cancer Therapeutics
We present the development of stimuli-responsive microcapsules, loaded with a viral immunogenetic agent, harnessing the immune response against the Coronavirus Disease 2019, COVID-19, to selectively attack liver cancer cells (hepatoma) or recognize breast cancer or hepatoma, by expression of green fluorescence protein, GFP. The pH-responsive microcapsules, modified with DNA-tetrahedra nanostructures, increased hepatoma permeation by 50%. Incorporation of a GFP-encoding lentivirus vector inside the tumor-targeting pH-stimulated miRNA-triggered and Alpha-fetoprotein-dictated microcapsules enables the demonstration of neoplas...
Source: Angewandte Chemie - September 7, 2023 Category: Chemistry Authors: Amit Fischer Avner Ehrlich Yevgeni Plotkin Yu Ouyang Klil Asulin Ioannidis Konstantinos Chunhai Fan Yaakov Nahmias Itamar Willner Source Type: research
Residual burden of liver disease after HCV clearance in hemophilia: a word of caution in the era of gene therapy
Blood Adv. 2023 Jul 28:bloodadvances.2023010723. doi: 10.1182/bloodadvances.2023010723. Online ahead of print.ABSTRACTRuling out advanced fibrosis/cirrhosis is mandatory for persons with hemophilia (PWH) who are candidate to gene therapy. However, clinical evaluation and non-invasive tests may be inaccurate after HCV clearance. We conducted a prospective hepatological screening to detect advanced fibrosis/cirrhosis in PWH after HCV clearance. Any risk factor of chronic liver damage was registered by using biochemical data, liver stiffness measurement (LSM) and ultrasound (US). A pre/post HCV clearance analysis was prospect...
Source: Adv Data - July 28, 2023 Category: Epidemiology Authors: Vincenzo La Mura Niccol ò Bitto Cecilia Capelli Camilla Caputo Simona Maria Siboni Sara Arcudi Alessandro Ciavarella Roberta Gualtierotti Anna Ludovica Fracanzani Angelo Sangiovanni Flora Peyvandi Source Type: research
AAV induces hepatic necroptosis and carcinoma in diabetic and obese mice dependent on Pebp1 pathway
EMBO Mol Med. 2023 Jun 5:e17230. doi: 10.15252/emmm.202217230. Online ahead of print.ABSTRACTObesity and diabetes are risk factors for hepatocellular carcinoma (HCC); however, the underlying mechanisms are yet to be elucidated. Adeno-associated virus (AAV) frequently infects humans and has been widely used in gene therapy, but the risk of AAV infection such as HCC should be further evaluated. Here, we show that recombinant AAV injection caused liver injury, hepatic necroptosis, and HCC in db/db or high-fat diet-induced hyperglycemic and obese mice, but not in mice with only hyperglycemia or obesity. Prednisone administrati...
Source: Molecular Medicine - June 5, 2023 Category: Molecular Biology Authors: Yalan Cheng Zhentong Zhang Peidong Gao Hejin Lai Wuling Zhong Ning Feng Yale Yang Huimin Yu Yali Zhang Yumo Han Jieya Dong Zhishui He Rui Huang Qiwei Zhai Source Type: research
Comprehensive Analysis of TICRR in Hepatocellular Carcinoma Based on Bioinformatics Analysis
This study demonstrated that increased TICRR expression in HCC might play an important role in the tumorigenesis, progression, diagnosis, and predicting prognosis of HCC. Therefore, TICRR might be used as a promising diagnostic and prognostic biomarker for HCC gene therapy.PMID:37266876 | DOI:10.1007/s10528-023-10378-w
Source: Biochemical Genetics - June 2, 2023 Category: Genetics & Stem Cells Authors: Jing-Jing Chen Lu-Lu Zhang Zhen Liu Wan Qi Men Fang Chen Jilu Shen Source Type: research
Vector-Mediated Cancer Gene Therapy Reduces Toxicity and Inhibition of Lung Carcinoma Growth in Nude Mice
Appl Biochem Biotechnol. 2023 Apr 29. doi: 10.1007/s12010-023-04463-4. Online ahead of print.ABSTRACTReplication-competent oncolytic adenovirus (TOA2) gene therapy is a recently introduced anti-tumor treatment regimen with superior results. The biodistribution studies of virus vector-based medicine seem more cautious and have been given much attention recently in terms of its quality and safety in preclinical trials. The current study determined the biodistribution and safety of a replication-competent adenovirus in different organs to predict its toxicity threshold. The present study has used TOA2, while biodistribution a...
Source: Applied Biochemistry and Biotechnology - April 29, 2023 Category: Biochemistry Authors: Ahmad Taha Khalaf Jun Wan Hu Wei Shen Fubing Jamaludin Zainol Samiah Yasmin Abdul Kadir Min Liang Source Type: research
Glycopolymers Mediate Suicide Gene Therapy in ASGPR-Expressing Hepatocellular Carcinoma Cells in Tandem with Docetaxel
Biomacromolecules. 2023 Feb 13. doi: 10.1021/acs.biomac.2c01329. Online ahead of print.ABSTRACTCationic glycopolymers stand out as gene delivery nanosystems due to their inherent biocompatibility and high binding affinity to the asialoglycoprotein receptor (ASGPR), a target receptor overexpressed in hepatocellular carcinoma (HCC) cells. However, their synthesis procedure remains laborious and complex, with problems of solubilization and the need for protection/deprotection steps. Here, a mini-library of well-defined poly(2-aminoethyl methacrylate hydrochloride-co-poly(2-lactobionamidoethyl methacrylate) (PAMA-co-PLAMA) gly...
Source: Biomacromolecules - February 13, 2023 Category: Biochemistry Authors: Daniela Santo Rosemeyre A Cordeiro Patr ícia V Mendonça Arm énio C Serra Jorge F J Coelho Henrique Faneca Source Type: research
The Role of Alpha-Fetoprotein (AFP) in Contemporary Oncology: The Path from a Diagnostic Biomarker to an Anticancer Drug
This article presents contemporary opinion on the role of alpha-fetoprotein in oncologic diagnostics and treatment. This role stretches far beyond the already known one-that of the biomarker of hepatocellular carcinoma. The turn of the 20th and 21st centuries saw a significant increase in knowledge about the fundamental role of AFP in the neoplastic processes, and in the induction of features of malignance and drug resistance of hepatocellular carcinoma. The impact of AFP on the creation of an immunosuppressive environment for the developing tumor was identified, giving rise to attempts at immunotherapy. The paper presents...
Source: Molecular Medicine - February 11, 2023 Category: Molecular Biology Authors: Joanna G łowska-Ciemny Marcin Szyma ński Agata Kuszerska Zbyszko Malewski Constantin von Kaisenberg Rafa ł Kocyłowski Source Type: research
