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Specialty: Research
Cancer: Hepatocellular Carcinoma
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Total 115 results found since Jan 2013.
miR-125a-5p-targeted regulation of TRA2 β expression inhibits proliferation and metastasis of hepatocellular carcinoma cells
CONCLUSION: miR-125a-5p inhibits the invasive capacity of HCC cells through targeting the TRA2β pathway.PMID:35035750 | PMC:PMC8748114
Source: American Journal of Translational Research - January 17, 2022 Category: Research Authors: Junde Zhou Linna Wang Yunfu Cui Lanhua Tang Source Type: research
Crocetin Imparts Antiproliferative Activity via Inhibiting STAT3 Signaling in Hepatocellular Carcinoma
In this study, we investigated the effect of crocetin on the growth of HCC cells and dissected its underlying molecular mechanism in imparting a cytotoxic effect. Crocetin suppressed proliferation, promoted apoptosis, and counteracted the invasive capacity of HCC cells. Besides, crocetin downregulated the constitutive/inducible STAT3 activation (Y705), nuclear accumulation of STAT3 along with suppression of its DNA binding activity in HCC cells with no effect on STAT5 activation. Crocetin suppressed the activity of upstream kinases such as Src, JAK1, and JAK2. Sodium pervanadate treatment terminated the crocetin-propelled ...
Source: IUBMB Life - September 14, 2021 Category: Research Authors: Chakrabhavi Dhananjaya Mohan,
Chulwon Kim,
Kodappully Sivaraman Siveen,
Kanjoormana Aryan Manu,
Shobith Rangappa,
Arunachalam Chinnathambi,
Sulaiman Ali Alharbi,
Kanchugarakoppal S. Rangappa,
Alan Prem Kumar,
Kwang Seok Ahn Tags: RESEARCH COMMUNICATION Source Type: research
Circ_0072088 promotes progression of hepatocellular carcinoma by activating JAK2/STAT3 signaling pathway via miR ‐375
AbstractCircular RNAs feature prominently in cancer development. Nonetheless, the role of circ_0072088 in hepatocellular carcinoma (HCC) remains unclear. GEO databases (GSE97332, GSE108724, GSE36915, and GSE33006) were used to screen out the differentially expressed circRNAs, miRNAs, and mRNA in HCC. The expressions of circ_0072088, miR-375, and Janus Kinase 2 (JAK2) mRNA in HCC tissue and cell lines were determined with quantitative real-time polymerase chain reaction. RNase R treatment assay was used to measure the stability of circ_0072088, and subcellular fraction assay was used to detect the localization of circ_00720...
Source: IUBMB Life - August 13, 2021 Category: Research Authors: Liheng Li,
Chengjiang Xiao,
Ke He,
Guoan Xiang Tags: RESEARCH COMMUNICATION Source Type: research
Long Noncoding RNASBF2-AS1 Promotes Gastric Cancer Progression via Regulating miR-545/EMS1 Axis.
Conclusion: These findings elucidated a crucial role of SBF2-AS1 as a miR-545 sponge in GC cells, suggesting that SBF2-AS1 might be a potential target for GC.
PMID: 32626753 [PubMed - in process]
Source: Biomed Res - July 8, 2020 Category: Research Authors: He M, Feng L, Qi L, Rao M, Zhu Y Tags: Biomed Res Int Source Type: research
CXCR3 confers sorafenib resistance of HCC cells through regulating metabolic alteration and AMPK pathway.
Authors: Ren Y, Gu YK, Li Z, Xu GZ, Zhang YM, Dong MX, Wang Y, Zhou XB
Abstract
Currently, the acquired resistance of the hepatocellular carcinoma (HCC) first-line therapeutic agent-sorafenib (SOR) remains a major challenge for HCC management. Recent evidence suggested the association between CXCL/CXCRs chemokines and chemotherapy resistant in cancer cells. Hence, exploring the internal mechanism of CXCRs involved in SOR resistance will help to improve the efficacy of HCC. SOR-resistant HCC cells (Huh7-SOR) were established through escalating concentration of SOR. Glucose consumption, lactate production, intracellu...
Source: American Journal of Translational Research - April 11, 2020 Category: Research Tags: Am J Transl Res Source Type: research
Long Non-Coding RNA MACC1-AS1 Is Involved in Distant Recurrence of Hepatocellular Carcinoma After Surgical Resection.
CONCLUSIONS MACC1-AS1 is involved in the distant recurrence of HCC, and its actions are possibly mediated by TGF-ß1.
PMID: 32267834 [PubMed - in process]
Source: Medical Science Monitor - April 10, 2020 Category: Research Tags: Med Sci Monit Source Type: research
Long Noncoding RNA (lncRNA) MIR22HG Suppresses Gastric Cancer Progression through Attenuating NOTCH2 Signaling.
CONCLUSIONS LncRNA MIR22HG suppressed gastric cancer progression through attenuating NOTCH2 signaling.
PMID: 30670679 [PubMed - in process]
Source: Medical Science Monitor - January 24, 2019 Category: Research Tags: Med Sci Monit Source Type: research
Repin1 deficiency in liver tissue alleviates NAFLD progression in mice
This study provides evidence that loss of Repin1 in the liver attenuates NAFLD progression, most likely by reducing fat accumulation and alleviating chronic tissue inflammation. Thus, modulating Repin1 expression may become a novel strategy and potential tool to inhibit NAFLD progression.Graphical abstract
Source: Journal of Advanced Research - November 23, 2018 Category: Research Source Type: research
Silencing of Xeroderma Pigmentosum Group D Gene Promotes Hepatoma Cell Growth by Reducing P53 Expression.
CONCLUSIONS Our data revealed that XPD silencing promoted growth of hepatoma cells by reducing P53 expression.
PMID: 30409962 [PubMed - in process]
Source: Medical Science Monitor - November 11, 2018 Category: Research Tags: Med Sci Monit Source Type: research
Increased Expression of Lysine-Specific Demethylase 5B (KDM5B) Promotes Tumor Cell Growth in Hep3B Cells and is an Independent Prognostic Factor in Patients with Hepatocellular Carcinoma.
CONCLUSIONS Increased expression of KDM5B was significantly correlated with poorer prognosis in patients with patients with HCC, indicating the possible potential of KDM5B as a novel clinical biomarker and therapeutic target.
PMID: 30353907 [PubMed - in process]
Source: Medical Science Monitor - October 26, 2018 Category: Research Tags: Med Sci Monit Source Type: research
